Is SSRI use a risk factor for intracranial hemorrhage after craniotomy for tumor resection?
Introduction: Prior studies have identified SSRI use as a risk factor for certain adverse bleeding outcomes. However, the risk of significant bleeding from perioperative SSRI use after brain tumor resection remains largely undetermined. This study evaluates if patients taking SSRIs perioperatively h...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | World Neurosurgery: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590139724000401 |
| _version_ | 1797279292549234688 |
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| author | Bradley J. Estes Ahmad R. Masri Roukoz Chamoun |
| author_facet | Bradley J. Estes Ahmad R. Masri Roukoz Chamoun |
| author_sort | Bradley J. Estes |
| collection | DOAJ |
| description | Introduction: Prior studies have identified SSRI use as a risk factor for certain adverse bleeding outcomes. However, the risk of significant bleeding from perioperative SSRI use after brain tumor resection remains largely undetermined. This study evaluates if patients taking SSRIs perioperatively have a higher risk of intracranial hemorrhage (ICH) following elective craniotomy for tumor resection. Methods: Researchers reviewed electronic medical records of patients age 18 and older, who received elective craniotomy for tumor resection between 2010 and 2019. Data collection included subject demographics and relevant medical history. We compared intracranial hemorrhage rates and risks between perioperative SSRI-use cohorts. Results: Of 1,061 patients, 796 (75%) did not use SSRIs perioperatively while 265 (25%) used SSRIs perioperatively. Among those using perioperative SSRIs, 8 patients (3.0%) experienced an ICH within 1 week and 11 patients (4.2%) had an ICH within 1 month. Similarly, for those who stopped SSRI use perioperatively, we found 31 patients (3.9%) experienced an ICH within 1 week and 40 patients (5.0%) had an ICH within 1 month. Using logistic regression analysis, the relative risk for perioperative SSRI-use and ICH was statistically non-significant at 0.692 (95% CI: 0.260 - 1.839, p = 0.460). Conclusions: Based on our results, perioperative SSRI use does not appear to result in an increased risk of bleeding within 1 week or month of craniotomy for tumor resection. These results remained consistent when controlled for several additional bleeding comorbidities and demographics between cohorts |
| first_indexed | 2024-03-07T16:23:11Z |
| format | Article |
| id | doaj.art-eac62de21e5642d0bcb177713267420c |
| institution | Directory Open Access Journal |
| issn | 2590-1397 |
| language | English |
| last_indexed | 2024-03-07T16:23:11Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Neurosurgery: X |
| spelling | doaj.art-eac62de21e5642d0bcb177713267420c2024-03-04T04:12:19ZengElsevierWorld Neurosurgery: X2590-13972024-04-0122100309Is SSRI use a risk factor for intracranial hemorrhage after craniotomy for tumor resection?Bradley J. Estes0Ahmad R. Masri1Roukoz Chamoun2The University of Kansas Medical Center, School of Medicine, Kansas City, KS, USA; The University of Kansas Medical Center, Department of Neurosurgery, Kansas City, KS, USA; Corresponding author. The University of Kansas Medical Center, School of Medicine, Kansas City, KS, USA.The University of Kansas Medical Center, Department of Neurosurgery, Kansas City, KS, USAThe University of Kansas Medical Center, Department of Neurosurgery, Kansas City, KS, USAIntroduction: Prior studies have identified SSRI use as a risk factor for certain adverse bleeding outcomes. However, the risk of significant bleeding from perioperative SSRI use after brain tumor resection remains largely undetermined. This study evaluates if patients taking SSRIs perioperatively have a higher risk of intracranial hemorrhage (ICH) following elective craniotomy for tumor resection. Methods: Researchers reviewed electronic medical records of patients age 18 and older, who received elective craniotomy for tumor resection between 2010 and 2019. Data collection included subject demographics and relevant medical history. We compared intracranial hemorrhage rates and risks between perioperative SSRI-use cohorts. Results: Of 1,061 patients, 796 (75%) did not use SSRIs perioperatively while 265 (25%) used SSRIs perioperatively. Among those using perioperative SSRIs, 8 patients (3.0%) experienced an ICH within 1 week and 11 patients (4.2%) had an ICH within 1 month. Similarly, for those who stopped SSRI use perioperatively, we found 31 patients (3.9%) experienced an ICH within 1 week and 40 patients (5.0%) had an ICH within 1 month. Using logistic regression analysis, the relative risk for perioperative SSRI-use and ICH was statistically non-significant at 0.692 (95% CI: 0.260 - 1.839, p = 0.460). Conclusions: Based on our results, perioperative SSRI use does not appear to result in an increased risk of bleeding within 1 week or month of craniotomy for tumor resection. These results remained consistent when controlled for several additional bleeding comorbidities and demographics between cohortshttp://www.sciencedirect.com/science/article/pii/S2590139724000401Selective serotonin reuptake inhibitorIntracranial hemorrhageRisk factor |
| spellingShingle | Bradley J. Estes Ahmad R. Masri Roukoz Chamoun Is SSRI use a risk factor for intracranial hemorrhage after craniotomy for tumor resection? World Neurosurgery: X Selective serotonin reuptake inhibitor Intracranial hemorrhage Risk factor |
| title | Is SSRI use a risk factor for intracranial hemorrhage after craniotomy for tumor resection? |
| title_full | Is SSRI use a risk factor for intracranial hemorrhage after craniotomy for tumor resection? |
| title_fullStr | Is SSRI use a risk factor for intracranial hemorrhage after craniotomy for tumor resection? |
| title_full_unstemmed | Is SSRI use a risk factor for intracranial hemorrhage after craniotomy for tumor resection? |
| title_short | Is SSRI use a risk factor for intracranial hemorrhage after craniotomy for tumor resection? |
| title_sort | is ssri use a risk factor for intracranial hemorrhage after craniotomy for tumor resection |
| topic | Selective serotonin reuptake inhibitor Intracranial hemorrhage Risk factor |
| url | http://www.sciencedirect.com/science/article/pii/S2590139724000401 |
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