Effects of post-renal anemia treatment with the HIF-PHD inhibitor molidustat on adenine-induced renal anemia and kidney disease in mice

Effects of post-renal anemia treatment with the HIF-PHD inhibitor molidustat on adenine-induced renal anemia and kidney disease in mice

The kidneys are the major organs for erythropoietin (EPO) production in adults, and thus, kidney damage results in reduced EPO levels and anemia. Inhibitors of Hypoxia-inducible factor-prolyl hydroxylase domain-containing protein (HIF-PHD) are awaited as new therapeutic options for renal anemia. It...

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Bibliographic Details
Main Authors: Lei Li, Daisuke Nakano, Anqi Zhang, Wararat Kittikulsuth, Norihiko Morisawa, Hiroyuki Ohsaki, Norio Suzuki, Masayuki Yamamoto, Akira Nishiyama
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Journal of Pharmacological Sciences
Subjects:
HIF stabilizer
Erythropoietin
Anemia
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320300943

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