Molecular diversity of extended-spectrum β-lactamases and carbapenemases, and antimicrobial resistance
Abstract Along with the recent spread of multidrug-resistant bacteria, outbreaks of extended-spectrum β-lactamase (ESBL) and carbapenemase-producing bacteria present a serious challenge to clinicians. β-lactam antibiotics are the most frequently used antibacterial agents and ESBLs, and carbapenemase...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-01-01
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| Series: | Journal of Intensive Care |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40560-020-0429-6 |
| _version_ | 1818557195564875776 |
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| author | Teiji Sawa Kunihiko Kooguchi Kiyoshi Moriyama |
| author_facet | Teiji Sawa Kunihiko Kooguchi Kiyoshi Moriyama |
| author_sort | Teiji Sawa |
| collection | DOAJ |
| description | Abstract Along with the recent spread of multidrug-resistant bacteria, outbreaks of extended-spectrum β-lactamase (ESBL) and carbapenemase-producing bacteria present a serious challenge to clinicians. β-lactam antibiotics are the most frequently used antibacterial agents and ESBLs, and carbapenemases confer resistance not only to carbapenem antibiotics but also to penicillin and cephem antibiotics. The mechanism of β-lactam resistance involves an efflux pump, reduced permeability, altered transpeptidases, and inactivation by β-lactamases. Horizontal gene transfer is the most common mechanism associated with the spread of extended-spectrum β-lactam- and carbapenem resistance among pathogenic bacterial species. Along with the increase in antimicrobial resistance, many different types of ESBLs and carbapenemases have emerged with different enzymatic characteristics. For example, carbapenemases are represented across classes A to D of the Ambler classification system. Because bacteria harboring different types of ESBLs and carbapenemases require specific therapeutic strategies, it is essential for clinicians to understand the characteristics of infecting pathogens. In this review, we summarize the current knowledge on carbapenem resistance by ESBLs and carbapenemases, such as class A carbapenemases, class C extended-spectrum AmpC (ESAC), carbapenem-hydrolyzing class D β-lactamases (CHDLs), and class B metallo-β-lactamases, with the aim of aiding critical care clinicians in their therapeutic decision making. |
| first_indexed | 2024-12-13T23:56:43Z |
| format | Article |
| id | doaj.art-eacdab616c644ca6be375a7cac4a0f77 |
| institution | Directory Open Access Journal |
| issn | 2052-0492 |
| language | English |
| last_indexed | 2024-12-13T23:56:43Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Intensive Care |
| spelling | doaj.art-eacdab616c644ca6be375a7cac4a0f772022-12-21T23:26:31ZengBMCJournal of Intensive Care2052-04922020-01-018111310.1186/s40560-020-0429-6Molecular diversity of extended-spectrum β-lactamases and carbapenemases, and antimicrobial resistanceTeiji Sawa0Kunihiko Kooguchi1Kiyoshi Moriyama2Department of Anesthesiology, School of Medicine, Kyoto Prefectural University of MedicineDepartment of Intensive Care, Kyoto City HospitalDepartment of Anesthesiology, School of Medicine, Kyorin UniversityAbstract Along with the recent spread of multidrug-resistant bacteria, outbreaks of extended-spectrum β-lactamase (ESBL) and carbapenemase-producing bacteria present a serious challenge to clinicians. β-lactam antibiotics are the most frequently used antibacterial agents and ESBLs, and carbapenemases confer resistance not only to carbapenem antibiotics but also to penicillin and cephem antibiotics. The mechanism of β-lactam resistance involves an efflux pump, reduced permeability, altered transpeptidases, and inactivation by β-lactamases. Horizontal gene transfer is the most common mechanism associated with the spread of extended-spectrum β-lactam- and carbapenem resistance among pathogenic bacterial species. Along with the increase in antimicrobial resistance, many different types of ESBLs and carbapenemases have emerged with different enzymatic characteristics. For example, carbapenemases are represented across classes A to D of the Ambler classification system. Because bacteria harboring different types of ESBLs and carbapenemases require specific therapeutic strategies, it is essential for clinicians to understand the characteristics of infecting pathogens. In this review, we summarize the current knowledge on carbapenem resistance by ESBLs and carbapenemases, such as class A carbapenemases, class C extended-spectrum AmpC (ESAC), carbapenem-hydrolyzing class D β-lactamases (CHDLs), and class B metallo-β-lactamases, with the aim of aiding critical care clinicians in their therapeutic decision making.https://doi.org/10.1186/s40560-020-0429-6β-Lactamβ-LactamaseCarbapenemaseClassificationMultidrug resistance |
| spellingShingle | Teiji Sawa Kunihiko Kooguchi Kiyoshi Moriyama Molecular diversity of extended-spectrum β-lactamases and carbapenemases, and antimicrobial resistance Journal of Intensive Care β-Lactam β-Lactamase Carbapenemase Classification Multidrug resistance |
| title | Molecular diversity of extended-spectrum β-lactamases and carbapenemases, and antimicrobial resistance |
| title_full | Molecular diversity of extended-spectrum β-lactamases and carbapenemases, and antimicrobial resistance |
| title_fullStr | Molecular diversity of extended-spectrum β-lactamases and carbapenemases, and antimicrobial resistance |
| title_full_unstemmed | Molecular diversity of extended-spectrum β-lactamases and carbapenemases, and antimicrobial resistance |
| title_short | Molecular diversity of extended-spectrum β-lactamases and carbapenemases, and antimicrobial resistance |
| title_sort | molecular diversity of extended spectrum β lactamases and carbapenemases and antimicrobial resistance |
| topic | β-Lactam β-Lactamase Carbapenemase Classification Multidrug resistance |
| url | https://doi.org/10.1186/s40560-020-0429-6 |
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