Phase Angle and Handgrip Strength as Predictors of Clinical Outcomes in Hospitalized COVID-19 Patients
Phase angle (PhA) and muscle strength are predictors of clinical outcomes in critically ill patients. Malnutrition may affect body composition measurements. The aim of this prospective study was to investigate the association between PhA and handgrip strength (HGS), and clinical outcomes in hospital...
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MDPI AG
2023-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/6/1409 |
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| author | Androniki Papaemmanouil Dimitra Rafailia Bakaloudi Konstantina Gkantali Georgios Kalopitas Simeon Metallidis Georgios Germanidis Michael Chourdakis |
| author_facet | Androniki Papaemmanouil Dimitra Rafailia Bakaloudi Konstantina Gkantali Georgios Kalopitas Simeon Metallidis Georgios Germanidis Michael Chourdakis |
| author_sort | Androniki Papaemmanouil |
| collection | DOAJ |
| description | Phase angle (PhA) and muscle strength are predictors of clinical outcomes in critically ill patients. Malnutrition may affect body composition measurements. The aim of this prospective study was to investigate the association between PhA and handgrip strength (HGS), and clinical outcomes in hospitalized COVID-19 patients. The study included a total of 102 patients. Both PhA and HGS were measured twice, within 48 h of hospital admission and on the 7th day of hospitalization. The primary outcome was the clinical status on the 28th day of hospitalization. Secondary outcomes included the hospital length of stay (LOS), the concentrations of ferritin, C-reactive protein and albumin, oxygen requirements and the severity of pneumonia. A one-way analysis of variance (ANOVA) test and Spearman r<sub>S</sub> correlation coefficient were used for statistical analysis. No differences were found for PhA [on day 1 (<i>p</i> = 0.769) and day 7 (<i>p</i> = 0.807)] and the primary outcome. A difference was found between HGS on day 1 and the primary outcome (<i>p</i> = 0.008), while no difference was found for HGS on day 7 (<i>p</i> = 0.476). Body mass index was found to be associated with the oxygen requirement on day 7 (<i>p</i> = 0.005). LOS was correlated neither with PhA (r<sub>s</sub> = −0.081, <i>p</i> = 0.422) nor with HGS (r<sub>s</sub> = 0.137, <i>p</i> = 0.177) on the first day. HGS could be a useful indicator of clinical outcomes in COVID-19 patients, while PhA does not seem to have a clinical impact. However, further research is needed to validate the results of our study. |
| first_indexed | 2024-03-11T06:04:43Z |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T06:04:43Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-eace4fb96e5340c68a915612489b35f22023-11-17T13:05:22ZengMDPI AGNutrients2072-66432023-03-01156140910.3390/nu15061409Phase Angle and Handgrip Strength as Predictors of Clinical Outcomes in Hospitalized COVID-19 PatientsAndroniki Papaemmanouil0Dimitra Rafailia Bakaloudi1Konstantina Gkantali2Georgios Kalopitas3Simeon Metallidis4Georgios Germanidis5Michael Chourdakis6Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceLaboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDivision of Infectious Diseases, 1st Department of Internal Medicine, AHEPA University Hospital, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54636 Thessaloniki, GreeceLaboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceDivision of Infectious Diseases, 1st Department of Internal Medicine, AHEPA University Hospital, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54636 Thessaloniki, GreeceDivision of Gastroenterology and Hepatology, 1st Department of Internal Medicine, AHEPA University Hospital, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54636 Thessaloniki, GreeceLaboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreecePhase angle (PhA) and muscle strength are predictors of clinical outcomes in critically ill patients. Malnutrition may affect body composition measurements. The aim of this prospective study was to investigate the association between PhA and handgrip strength (HGS), and clinical outcomes in hospitalized COVID-19 patients. The study included a total of 102 patients. Both PhA and HGS were measured twice, within 48 h of hospital admission and on the 7th day of hospitalization. The primary outcome was the clinical status on the 28th day of hospitalization. Secondary outcomes included the hospital length of stay (LOS), the concentrations of ferritin, C-reactive protein and albumin, oxygen requirements and the severity of pneumonia. A one-way analysis of variance (ANOVA) test and Spearman r<sub>S</sub> correlation coefficient were used for statistical analysis. No differences were found for PhA [on day 1 (<i>p</i> = 0.769) and day 7 (<i>p</i> = 0.807)] and the primary outcome. A difference was found between HGS on day 1 and the primary outcome (<i>p</i> = 0.008), while no difference was found for HGS on day 7 (<i>p</i> = 0.476). Body mass index was found to be associated with the oxygen requirement on day 7 (<i>p</i> = 0.005). LOS was correlated neither with PhA (r<sub>s</sub> = −0.081, <i>p</i> = 0.422) nor with HGS (r<sub>s</sub> = 0.137, <i>p</i> = 0.177) on the first day. HGS could be a useful indicator of clinical outcomes in COVID-19 patients, while PhA does not seem to have a clinical impact. However, further research is needed to validate the results of our study.https://www.mdpi.com/2072-6643/15/6/1409COVID-19handgrip strengthphase angleSARS-CoV-2 virus |
| spellingShingle | Androniki Papaemmanouil Dimitra Rafailia Bakaloudi Konstantina Gkantali Georgios Kalopitas Simeon Metallidis Georgios Germanidis Michael Chourdakis Phase Angle and Handgrip Strength as Predictors of Clinical Outcomes in Hospitalized COVID-19 Patients Nutrients COVID-19 handgrip strength phase angle SARS-CoV-2 virus |
| title | Phase Angle and Handgrip Strength as Predictors of Clinical Outcomes in Hospitalized COVID-19 Patients |
| title_full | Phase Angle and Handgrip Strength as Predictors of Clinical Outcomes in Hospitalized COVID-19 Patients |
| title_fullStr | Phase Angle and Handgrip Strength as Predictors of Clinical Outcomes in Hospitalized COVID-19 Patients |
| title_full_unstemmed | Phase Angle and Handgrip Strength as Predictors of Clinical Outcomes in Hospitalized COVID-19 Patients |
| title_short | Phase Angle and Handgrip Strength as Predictors of Clinical Outcomes in Hospitalized COVID-19 Patients |
| title_sort | phase angle and handgrip strength as predictors of clinical outcomes in hospitalized covid 19 patients |
| topic | COVID-19 handgrip strength phase angle SARS-CoV-2 virus |
| url | https://www.mdpi.com/2072-6643/15/6/1409 |
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