A receptor-antibody hybrid hampering MET-driven metastatic spread

A receptor-antibody hybrid hampering MET-driven metastatic spread

Abstract Background The receptor encoded by the MET oncogene and its ligand Hepatocyte Growth Factor (HGF) are at the core of the invasive-metastatic behavior. In a number of instances genetic alterations result in ligand-independent onset of malignancy (MET addiction). More frequently, ligand stimu...

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Bibliographic Details
Main Authors: Chiara Modica, Cristina Basilico, Cristina Chiriaco, Nicla Borrelli, Paolo M. Comoglio, Elisa Vigna
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
MET
HGF
Metastasis
Targeted therapy
Fusion proteins
Online Access:https://doi.org/10.1186/s13046-020-01822-5

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