Detecting overlapping protein complexes by rough-fuzzy clustering in protein-protein interaction networks.
In this paper, we present a novel rough-fuzzy clustering (RFC) method to detect overlapping protein complexes in protein-protein interaction (PPI) networks. RFC focuses on fuzzy relation model rather than graph model by integrating fuzzy sets and rough sets, employs the upper and lower approximation...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3958373?pdf=render |
| _version_ | 1819132738295300096 |
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| author | Hao Wu Lin Gao Jihua Dong Xiaofei Yang |
| author_facet | Hao Wu Lin Gao Jihua Dong Xiaofei Yang |
| author_sort | Hao Wu |
| collection | DOAJ |
| description | In this paper, we present a novel rough-fuzzy clustering (RFC) method to detect overlapping protein complexes in protein-protein interaction (PPI) networks. RFC focuses on fuzzy relation model rather than graph model by integrating fuzzy sets and rough sets, employs the upper and lower approximations of rough sets to deal with overlapping complexes, and calculates the number of complexes automatically. Fuzzy relation between proteins is established and then transformed into fuzzy equivalence relation. Non-overlapping complexes correspond to equivalence classes satisfying certain equivalence relation. To obtain overlapping complexes, we calculate the similarity between one protein and each complex, and then determine whether the protein belongs to one or multiple complexes by computing the ratio of each similarity to maximum similarity. To validate RFC quantitatively, we test it in Gavin, Collins, Krogan and BioGRID datasets. Experiment results show that there is a good correspondence to reference complexes in MIPS and SGD databases. Then we compare RFC with several previous methods, including ClusterONE, CMC, MCL, GCE, OSLOM and CFinder. Results show the precision, sensitivity and separation are 32.4%, 42.9% and 81.9% higher than mean of the five methods in four weighted networks, and are 0.5%, 11.2% and 66.1% higher than mean of the six methods in five unweighted networks. Our method RFC works well for protein complexes detection and provides a new insight of network division, and it can also be applied to identify overlapping community structure in social networks and LFR benchmark networks. |
| first_indexed | 2024-12-22T09:36:10Z |
| format | Article |
| id | doaj.art-eaced5c26b7645148c8e8e000408f4d7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T09:36:10Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-eaced5c26b7645148c8e8e000408f4d72022-12-21T18:30:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e9185610.1371/journal.pone.0091856Detecting overlapping protein complexes by rough-fuzzy clustering in protein-protein interaction networks.Hao WuLin GaoJihua DongXiaofei YangIn this paper, we present a novel rough-fuzzy clustering (RFC) method to detect overlapping protein complexes in protein-protein interaction (PPI) networks. RFC focuses on fuzzy relation model rather than graph model by integrating fuzzy sets and rough sets, employs the upper and lower approximations of rough sets to deal with overlapping complexes, and calculates the number of complexes automatically. Fuzzy relation between proteins is established and then transformed into fuzzy equivalence relation. Non-overlapping complexes correspond to equivalence classes satisfying certain equivalence relation. To obtain overlapping complexes, we calculate the similarity between one protein and each complex, and then determine whether the protein belongs to one or multiple complexes by computing the ratio of each similarity to maximum similarity. To validate RFC quantitatively, we test it in Gavin, Collins, Krogan and BioGRID datasets. Experiment results show that there is a good correspondence to reference complexes in MIPS and SGD databases. Then we compare RFC with several previous methods, including ClusterONE, CMC, MCL, GCE, OSLOM and CFinder. Results show the precision, sensitivity and separation are 32.4%, 42.9% and 81.9% higher than mean of the five methods in four weighted networks, and are 0.5%, 11.2% and 66.1% higher than mean of the six methods in five unweighted networks. Our method RFC works well for protein complexes detection and provides a new insight of network division, and it can also be applied to identify overlapping community structure in social networks and LFR benchmark networks.http://europepmc.org/articles/PMC3958373?pdf=render |
| spellingShingle | Hao Wu Lin Gao Jihua Dong Xiaofei Yang Detecting overlapping protein complexes by rough-fuzzy clustering in protein-protein interaction networks. PLoS ONE |
| title | Detecting overlapping protein complexes by rough-fuzzy clustering in protein-protein interaction networks. |
| title_full | Detecting overlapping protein complexes by rough-fuzzy clustering in protein-protein interaction networks. |
| title_fullStr | Detecting overlapping protein complexes by rough-fuzzy clustering in protein-protein interaction networks. |
| title_full_unstemmed | Detecting overlapping protein complexes by rough-fuzzy clustering in protein-protein interaction networks. |
| title_short | Detecting overlapping protein complexes by rough-fuzzy clustering in protein-protein interaction networks. |
| title_sort | detecting overlapping protein complexes by rough fuzzy clustering in protein protein interaction networks |
| url | http://europepmc.org/articles/PMC3958373?pdf=render |
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