Association of A2756G and A66G Polymorphisms With Male Infertility: An Updated Meta-Analysis
The objective of the present study was to find out the association of folate genes MTR A2756G and MTRR A66G polymorphisms with the risk of male infertility. The databases of Google Scholar, PubMed, and Science Direct were searched to find relevant studies. Data were extracted from the eligible studi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-05-01
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| Series: | American Journal of Men's Health |
| Online Access: | https://doi.org/10.1177/15579883231176657 |
| _version_ | 1797816562167578624 |
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| author | Tamjeed Tariq Adina Arshad Ayesha Bibi Shaista Aslam Anam Sohail Bilal Ishaq Muhammad Irfan |
| author_facet | Tamjeed Tariq Adina Arshad Ayesha Bibi Shaista Aslam Anam Sohail Bilal Ishaq Muhammad Irfan |
| author_sort | Tamjeed Tariq |
| collection | DOAJ |
| description | The objective of the present study was to find out the association of folate genes MTR A2756G and MTRR A66G polymorphisms with the risk of male infertility. The databases of Google Scholar, PubMed, and Science Direct were searched to find relevant studies. Data were extracted from the eligible studies and were analyzed for pooled up odds ratio (OR) with 95% confidence interval (CI). Review Manager 5.4 was used for statistical analysis. Nineteen case-control studies were included in this meta-analysis which comprised 3621 cases and 3327 controls. Pooled analysis revealed that there is a significant association between MTR A2756G polymorphism with male infertility except for the dominant model. The ORs and 95% CI for each genetic model were as follows: 1.21 [1.03–1.42] for the allele model (G vs. A), 2.31 [1.38–3.96] for the additive model (GG vs. AA), 1.17 [0.98–1.38] for the dominant model (GG+AG vs. AA) and 2.10 [1.55–2.86] for the recessive model (GG vs. AG+AA). MTRR A66G has no noticeable association with male infertility. The current meta-analysis suggests that MTR A2756G polymorphism might be a potential risk factor for male infertility. In the future, the sample size should be increased to confirm the present results. |
| first_indexed | 2024-03-13T08:39:33Z |
| format | Article |
| id | doaj.art-eacfc6b86a854f3087ed75cad3e496f2 |
| institution | Directory Open Access Journal |
| issn | 1557-9891 |
| language | English |
| last_indexed | 2024-03-13T08:39:33Z |
| publishDate | 2023-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | American Journal of Men's Health |
| spelling | doaj.art-eacfc6b86a854f3087ed75cad3e496f22023-05-30T19:03:46ZengSAGE PublishingAmerican Journal of Men's Health1557-98912023-05-011710.1177/15579883231176657Association of A2756G and A66G Polymorphisms With Male Infertility: An Updated Meta-AnalysisTamjeed Tariq0Adina Arshad1Ayesha Bibi2Shaista Aslam3Anam Sohail4Bilal Ishaq5Muhammad Irfan6Department of Zoology, Wildlife, and Fisheries, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi, PakistanDepartment of Zoology, Wildlife, and Fisheries, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi, PakistanDepartment of Zoology, Wildlife, and Fisheries, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi, PakistanDepartment of Biological Sciences, National University of Medical Sciences, Rawalpindi, PakistanDepartment of Zoology, Wildlife, and Fisheries, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi, PakistanDepartment of Zoology, Wildlife, and Fisheries, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi, PakistanDepartment of Zoology, Wildlife, and Fisheries, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi, PakistanThe objective of the present study was to find out the association of folate genes MTR A2756G and MTRR A66G polymorphisms with the risk of male infertility. The databases of Google Scholar, PubMed, and Science Direct were searched to find relevant studies. Data were extracted from the eligible studies and were analyzed for pooled up odds ratio (OR) with 95% confidence interval (CI). Review Manager 5.4 was used for statistical analysis. Nineteen case-control studies were included in this meta-analysis which comprised 3621 cases and 3327 controls. Pooled analysis revealed that there is a significant association between MTR A2756G polymorphism with male infertility except for the dominant model. The ORs and 95% CI for each genetic model were as follows: 1.21 [1.03–1.42] for the allele model (G vs. A), 2.31 [1.38–3.96] for the additive model (GG vs. AA), 1.17 [0.98–1.38] for the dominant model (GG+AG vs. AA) and 2.10 [1.55–2.86] for the recessive model (GG vs. AG+AA). MTRR A66G has no noticeable association with male infertility. The current meta-analysis suggests that MTR A2756G polymorphism might be a potential risk factor for male infertility. In the future, the sample size should be increased to confirm the present results.https://doi.org/10.1177/15579883231176657 |
| spellingShingle | Tamjeed Tariq Adina Arshad Ayesha Bibi Shaista Aslam Anam Sohail Bilal Ishaq Muhammad Irfan Association of A2756G and A66G Polymorphisms With Male Infertility: An Updated Meta-Analysis American Journal of Men's Health |
| title | Association of A2756G and A66G Polymorphisms With Male Infertility: An Updated Meta-Analysis |
| title_full | Association of A2756G and A66G Polymorphisms With Male Infertility: An Updated Meta-Analysis |
| title_fullStr | Association of A2756G and A66G Polymorphisms With Male Infertility: An Updated Meta-Analysis |
| title_full_unstemmed | Association of A2756G and A66G Polymorphisms With Male Infertility: An Updated Meta-Analysis |
| title_short | Association of A2756G and A66G Polymorphisms With Male Infertility: An Updated Meta-Analysis |
| title_sort | association of a2756g and a66g polymorphisms with male infertility an updated meta analysis |
| url | https://doi.org/10.1177/15579883231176657 |
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