<i>Wickerhamomyces</i> Yeast Killer Toxins’ Medical Applications
Possible implications and applications of the yeast killer phenomenon in the fight against infectious diseases are reviewed, with particular reference to some wide-spectrum killer toxins (KTs) produced by <i>Wickerhamomyces anomalus</i> and other related species. A perspective on the app...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6651/13/9/655 |
| _version_ | 1827681211581988864 |
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| author | Laura Giovati Tecla Ciociola Tiziano De Simone Stefania Conti Walter Magliani |
| author_facet | Laura Giovati Tecla Ciociola Tiziano De Simone Stefania Conti Walter Magliani |
| author_sort | Laura Giovati |
| collection | DOAJ |
| description | Possible implications and applications of the yeast killer phenomenon in the fight against infectious diseases are reviewed, with particular reference to some wide-spectrum killer toxins (KTs) produced by <i>Wickerhamomyces anomalus</i> and other related species. A perspective on the applications of these KTs in the medical field is provided considering (1) a direct use of killer strains, in particular in the symbiotic control of arthropod-borne diseases; (2) a direct use of KTs as experimental therapeutic agents; (3) the production, through the idiotypic network, of immunological derivatives of KTs and their use as potential anti-infective therapeutics. Studies on immunological derivatives of KTs in the context of vaccine development are also described. |
| first_indexed | 2024-03-10T07:10:07Z |
| format | Article |
| id | doaj.art-ead0bab2177c4dcc8c8ac0246db565ae |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T07:10:07Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-ead0bab2177c4dcc8c8ac0246db565ae2023-11-22T15:31:34ZengMDPI AGToxins2072-66512021-09-0113965510.3390/toxins13090655<i>Wickerhamomyces</i> Yeast Killer Toxins’ Medical ApplicationsLaura Giovati0Tecla Ciociola1Tiziano De Simone2Stefania Conti3Walter Magliani4Department of Medicine and Surgery, University of Parma, 43126 Parma, ItalyDepartment of Medicine and Surgery, University of Parma, 43126 Parma, ItalyDepartment of Medicine and Surgery, University of Parma, 43126 Parma, ItalyDepartment of Medicine and Surgery, University of Parma, 43126 Parma, ItalyDepartment of Medicine and Surgery, University of Parma, 43126 Parma, ItalyPossible implications and applications of the yeast killer phenomenon in the fight against infectious diseases are reviewed, with particular reference to some wide-spectrum killer toxins (KTs) produced by <i>Wickerhamomyces anomalus</i> and other related species. A perspective on the applications of these KTs in the medical field is provided considering (1) a direct use of killer strains, in particular in the symbiotic control of arthropod-borne diseases; (2) a direct use of KTs as experimental therapeutic agents; (3) the production, through the idiotypic network, of immunological derivatives of KTs and their use as potential anti-infective therapeutics. Studies on immunological derivatives of KTs in the context of vaccine development are also described.https://www.mdpi.com/2072-6651/13/9/655killer yeastskiller toxinsantimicrobial activitymedical applications<i>Wickerhamomyces anomalus</i> |
| spellingShingle | Laura Giovati Tecla Ciociola Tiziano De Simone Stefania Conti Walter Magliani <i>Wickerhamomyces</i> Yeast Killer Toxins’ Medical Applications Toxins killer yeasts killer toxins antimicrobial activity medical applications <i>Wickerhamomyces anomalus</i> |
| title | <i>Wickerhamomyces</i> Yeast Killer Toxins’ Medical Applications |
| title_full | <i>Wickerhamomyces</i> Yeast Killer Toxins’ Medical Applications |
| title_fullStr | <i>Wickerhamomyces</i> Yeast Killer Toxins’ Medical Applications |
| title_full_unstemmed | <i>Wickerhamomyces</i> Yeast Killer Toxins’ Medical Applications |
| title_short | <i>Wickerhamomyces</i> Yeast Killer Toxins’ Medical Applications |
| title_sort | i wickerhamomyces i yeast killer toxins medical applications |
| topic | killer yeasts killer toxins antimicrobial activity medical applications <i>Wickerhamomyces anomalus</i> |
| url | https://www.mdpi.com/2072-6651/13/9/655 |
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