Therapeutic Nanoparticles and Their Targeted Delivery Applications
Nanotechnology offers many advantages in various fields of science. In this regard, nanoparticles are the essential building blocks of nanotechnology. Recent advances in nanotechnology have proven that nanoparticles acquire a great potential in medical applications. Formation of stable interactions...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/9/2193 |
| _version_ | 1797568643791323136 |
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| author | Abuzer Alp Yetisgin Sibel Cetinel Merve Zuvin Ali Kosar Ozlem Kutlu |
| author_facet | Abuzer Alp Yetisgin Sibel Cetinel Merve Zuvin Ali Kosar Ozlem Kutlu |
| author_sort | Abuzer Alp Yetisgin |
| collection | DOAJ |
| description | Nanotechnology offers many advantages in various fields of science. In this regard, nanoparticles are the essential building blocks of nanotechnology. Recent advances in nanotechnology have proven that nanoparticles acquire a great potential in medical applications. Formation of stable interactions with ligands, variability in size and shape, high carrier capacity, and convenience of binding of both hydrophilic and hydrophobic substances make nanoparticles favorable platforms for the target-specific and controlled delivery of micro- and macromolecules in disease therapy. Nanoparticles combined with the therapeutic agents overcome problems associated with conventional therapy; however, some issues like side effects and toxicity are still debated and should be well concerned before their utilization in biological systems. It is therefore important to understand the specific properties of therapeutic nanoparticles and their delivery strategies. Here, we provide an overview on the unique features of nanoparticles in the biological systems. We emphasize on the type of clinically used nanoparticles and their specificity for therapeutic applications, as well as on their current delivery strategies for specific diseases such as cancer, infectious, autoimmune, cardiovascular, neurodegenerative, ocular, and pulmonary diseases. Understanding of the characteristics of nanoparticles and their interactions with the biological environment will enable us to establish novel strategies for the treatment, prevention, and diagnosis in many diseases, particularly untreatable ones. |
| first_indexed | 2024-03-10T19:58:53Z |
| format | Article |
| id | doaj.art-ead14d72691e4772831b2e9fe3a04eec |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T19:58:53Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-ead14d72691e4772831b2e9fe3a04eec2023-11-19T23:45:43ZengMDPI AGMolecules1420-30492020-05-01259219310.3390/molecules25092193Therapeutic Nanoparticles and Their Targeted Delivery ApplicationsAbuzer Alp Yetisgin0Sibel Cetinel1Merve Zuvin2Ali Kosar3Ozlem Kutlu4Materials Science and Nano-Engineering Program, Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul 34956, TurkeyNanotechnology Research and Application Center (SUNUM), Sabanci University, Istanbul 34956, TurkeyMechatronics Engineering Program, Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul 34956, TurkeyMechatronics Engineering Program, Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul 34956, TurkeyNanotechnology Research and Application Center (SUNUM), Sabanci University, Istanbul 34956, TurkeyNanotechnology offers many advantages in various fields of science. In this regard, nanoparticles are the essential building blocks of nanotechnology. Recent advances in nanotechnology have proven that nanoparticles acquire a great potential in medical applications. Formation of stable interactions with ligands, variability in size and shape, high carrier capacity, and convenience of binding of both hydrophilic and hydrophobic substances make nanoparticles favorable platforms for the target-specific and controlled delivery of micro- and macromolecules in disease therapy. Nanoparticles combined with the therapeutic agents overcome problems associated with conventional therapy; however, some issues like side effects and toxicity are still debated and should be well concerned before their utilization in biological systems. It is therefore important to understand the specific properties of therapeutic nanoparticles and their delivery strategies. Here, we provide an overview on the unique features of nanoparticles in the biological systems. We emphasize on the type of clinically used nanoparticles and their specificity for therapeutic applications, as well as on their current delivery strategies for specific diseases such as cancer, infectious, autoimmune, cardiovascular, neurodegenerative, ocular, and pulmonary diseases. Understanding of the characteristics of nanoparticles and their interactions with the biological environment will enable us to establish novel strategies for the treatment, prevention, and diagnosis in many diseases, particularly untreatable ones.https://www.mdpi.com/1420-3049/25/9/2193nanotechnologytherapeutic nanoparticlestargeted deliverydiseases treatment |
| spellingShingle | Abuzer Alp Yetisgin Sibel Cetinel Merve Zuvin Ali Kosar Ozlem Kutlu Therapeutic Nanoparticles and Their Targeted Delivery Applications Molecules nanotechnology therapeutic nanoparticles targeted delivery diseases treatment |
| title | Therapeutic Nanoparticles and Their Targeted Delivery Applications |
| title_full | Therapeutic Nanoparticles and Their Targeted Delivery Applications |
| title_fullStr | Therapeutic Nanoparticles and Their Targeted Delivery Applications |
| title_full_unstemmed | Therapeutic Nanoparticles and Their Targeted Delivery Applications |
| title_short | Therapeutic Nanoparticles and Their Targeted Delivery Applications |
| title_sort | therapeutic nanoparticles and their targeted delivery applications |
| topic | nanotechnology therapeutic nanoparticles targeted delivery diseases treatment |
| url | https://www.mdpi.com/1420-3049/25/9/2193 |
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