Formulation, optimization and evaluation of ocular gel containing nebivolol Hcl-loaded ultradeformable spanlastics nanovesicles: In vitro and in vivo studies

Formulation, optimization and evaluation of ocular gel containing nebivolol Hcl-loaded ultradeformable spanlastics nanovesicles: In vitro and in vivo studies

The study aims to improve the ocular delivery of Nebivolol HCL (NBV) belonging to the Biopharmaceutics classification system (BCSII) by using spanlastic nanovesicles (SNVs) for ophthalmic delivery and incorporating them into hydroxypropyl methylcellulose gel with ketorolac tromethamine (KET) as an a...

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Bibliographic Details
Main Authors: Mohamed Yasser, Eman E. El Naggar, Nehal Elfar, Mahmoud H. Teaima, Mohamed A. El-Nabarawi, Sammar Fathy Elhabal
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:International Journal of Pharmaceutics: X
Subjects:
Glaucoma
Spanlastic nanovesicles (SNVs)
Nebivolol
Ketorolac
Biopharmaceutics classification system (BCSII) and Labrasol
Confocal laser scanning
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156723000725

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http://www.sciencedirect.com/science/article/pii/S2590156723000725

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