The same strain of Piscine orthoreovirus (PRV-1) is involved in the development of different, but related, diseases in Atlantic and Pacific Salmon in British Columbia
Piscine orthoreovirus Strain PRV-1 is the causative agent of heart and skeletal muscle inflammation (HSMI) in Atlantic salmon (Salmo salar Linnaeus, 1758). Given its high prevalence in net pen salmon, debate has arisen on whether PRV poses a risk to migratory salmon, especially in British Columbia (...
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| Format: | Article |
| Language: | English |
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Canadian Science Publishing
2018-06-01
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| Series: | FACETS |
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| Online Access: | http://www.facetsjournal.com/doi/full/10.1139%2Ffacets-2018-0008 |
| _version_ | 1819042714407141376 |
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| author | Emiliano Di Cicco Hugh W. Ferguson Karia H. Kaukinen Angela D. Schulze Shaorong Li Amy Tabata Oliver P. Günther Gideon Mordecai Curtis A. Suttle Kristina M. Miller |
| author_facet | Emiliano Di Cicco Hugh W. Ferguson Karia H. Kaukinen Angela D. Schulze Shaorong Li Amy Tabata Oliver P. Günther Gideon Mordecai Curtis A. Suttle Kristina M. Miller |
| author_sort | Emiliano Di Cicco |
| collection | DOAJ |
| description | Piscine orthoreovirus Strain PRV-1 is the causative agent of heart and skeletal muscle inflammation (HSMI) in Atlantic salmon (Salmo salar Linnaeus, 1758). Given its high prevalence in net pen salmon, debate has arisen on whether PRV poses a risk to migratory salmon, especially in British Columbia (BC) where commercially important wild Pacific salmon are in decline. Various strains of PRV have been associated with diseases in Pacific salmon, including erythrocytic inclusion body syndrome (EIBS), HSMI-like disease, and jaundice/anemia in Japan, Norway, Chile and Canada. We examined the developmental pathway of HSMI and jaundice/anemia associated with PRV-1 in farmed Atlantic and chinook (Oncorhynchus tshawytscha (Walbaum, 1792)) salmon in BC, respectively. In situ hybridization localized PRV-1 within developing lesions in both diseases. The two diseases showed dissimilar pathological pathways, with inflammatory lesions in heart and skeletal muscle in Atlantic salmon and degenerative-necrotic lesions in kidney and liver in chinook salmon, plausibly explained by differences in PRV load tolerance in red blood cells. Viral genome sequencing revealed no consistent differences in PRV-1 variants intimately involved in the development of both diseases suggesting that migratory chinook salmon may be at more than a minimal risk of disease from exposure to the high levels of PRV occurring in salmon farms. |
| first_indexed | 2024-12-21T09:45:17Z |
| format | Article |
| id | doaj.art-ead5a5c1e97d400f98bed63f205f5382 |
| institution | Directory Open Access Journal |
| issn | 2371-1671 2371-1671 |
| language | English |
| last_indexed | 2024-12-21T09:45:17Z |
| publishDate | 2018-06-01 |
| publisher | Canadian Science Publishing |
| record_format | Article |
| series | FACETS |
| spelling | doaj.art-ead5a5c1e97d400f98bed63f205f53822022-12-21T19:08:21ZengCanadian Science PublishingFACETS2371-16712371-16712018-06-01359964110.1139/facets-2018-0008The same strain of Piscine orthoreovirus (PRV-1) is involved in the development of different, but related, diseases in Atlantic and Pacific Salmon in British ColumbiaEmiliano Di Cicco0Hugh W. Ferguson1Karia H. Kaukinen2Angela D. Schulze3Shaorong Li4Amy Tabata5Oliver P. Günther6Gideon Mordecai7Curtis A. Suttle8Kristina M. Miller9Pacific Biological Station, Fisheries and Oceans Canada, Nanaimo, BC V9T 6N7, Canada. Pacific Salmon Foundation, Vancouver, BC V6J 4S6, Canada.School of Veterinary Medicine, St. George’s University, True Blue, Grenada, West Indies.Pacific Biological Station, Fisheries and Oceans Canada, Nanaimo, BC V9T 6N7, Canada.Pacific Biological Station, Fisheries and Oceans Canada, Nanaimo, BC V9T 6N7, Canada.Pacific Biological Station, Fisheries and Oceans Canada, Nanaimo, BC V9T 6N7, Canada.Pacific Biological Station, Fisheries and Oceans Canada, Nanaimo, BC V9T 6N7, Canada.Günther Analytics, Vancouver, BC V6T 2G6, Canada.Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. Department of Microbiology and Immunology, Department of Botany, Institute for the Oceans and Fisheries, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.Pacific Biological Station, Fisheries and Oceans Canada, Nanaimo, BC V9T 6N7, Canada.Piscine orthoreovirus Strain PRV-1 is the causative agent of heart and skeletal muscle inflammation (HSMI) in Atlantic salmon (Salmo salar Linnaeus, 1758). Given its high prevalence in net pen salmon, debate has arisen on whether PRV poses a risk to migratory salmon, especially in British Columbia (BC) where commercially important wild Pacific salmon are in decline. Various strains of PRV have been associated with diseases in Pacific salmon, including erythrocytic inclusion body syndrome (EIBS), HSMI-like disease, and jaundice/anemia in Japan, Norway, Chile and Canada. We examined the developmental pathway of HSMI and jaundice/anemia associated with PRV-1 in farmed Atlantic and chinook (Oncorhynchus tshawytscha (Walbaum, 1792)) salmon in BC, respectively. In situ hybridization localized PRV-1 within developing lesions in both diseases. The two diseases showed dissimilar pathological pathways, with inflammatory lesions in heart and skeletal muscle in Atlantic salmon and degenerative-necrotic lesions in kidney and liver in chinook salmon, plausibly explained by differences in PRV load tolerance in red blood cells. Viral genome sequencing revealed no consistent differences in PRV-1 variants intimately involved in the development of both diseases suggesting that migratory chinook salmon may be at more than a minimal risk of disease from exposure to the high levels of PRV occurring in salmon farms.http://www.facetsjournal.com/doi/full/10.1139%2Ffacets-2018-0008PRVAtlantic salmonchinook salmonHSMIjaundice/anemiaVDDISH |
| spellingShingle | Emiliano Di Cicco Hugh W. Ferguson Karia H. Kaukinen Angela D. Schulze Shaorong Li Amy Tabata Oliver P. Günther Gideon Mordecai Curtis A. Suttle Kristina M. Miller The same strain of Piscine orthoreovirus (PRV-1) is involved in the development of different, but related, diseases in Atlantic and Pacific Salmon in British Columbia FACETS PRV Atlantic salmon chinook salmon HSMI jaundice/anemia VDD ISH |
| title | The same strain of Piscine orthoreovirus (PRV-1) is involved in the development of different, but related, diseases in Atlantic and Pacific Salmon in British Columbia |
| title_full | The same strain of Piscine orthoreovirus (PRV-1) is involved in the development of different, but related, diseases in Atlantic and Pacific Salmon in British Columbia |
| title_fullStr | The same strain of Piscine orthoreovirus (PRV-1) is involved in the development of different, but related, diseases in Atlantic and Pacific Salmon in British Columbia |
| title_full_unstemmed | The same strain of Piscine orthoreovirus (PRV-1) is involved in the development of different, but related, diseases in Atlantic and Pacific Salmon in British Columbia |
| title_short | The same strain of Piscine orthoreovirus (PRV-1) is involved in the development of different, but related, diseases in Atlantic and Pacific Salmon in British Columbia |
| title_sort | same strain of piscine orthoreovirus prv 1 is involved in the development of different but related diseases in atlantic and pacific salmon in british columbia |
| topic | PRV Atlantic salmon chinook salmon HSMI jaundice/anemia VDD ISH |
| url | http://www.facetsjournal.com/doi/full/10.1139%2Ffacets-2018-0008 |
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