Safeguarding genome integrity during gene-editing therapy in a mouse model of age-related macular degeneration
Undesired chromosomal translocations, vector integrations, and large deletions remain a problem for therapeutic gene editing in vivo. Here, the authors compare the CRISPR-Cas9TX variant with CRISPR-Cas9 and show elimination of chromosomal translocations and reduction of AVV integration when targetin...
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Bibliographic Details
| Main Authors: |
Jianhang Yin,
Kailun Fang,
Yanxia Gao,
Liqiong Ou,
Shaopeng Yuan,
Changchang Xin,
Weiwei Wu,
Wei-wei Wu,
Jiaxu Hong,
Hui Yang,
Jiazhi Hu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-35640-4
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