Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-centre cohort study
To further describe the effect of the “fragile population” and their “higher-risk” comorbidities on prognosis among hospitalized Omicron patients, this observational cohort study enrolled hospitalized patients confirmed with SARS-CoV-2 during the 2022 Omicron wave in Shanghai, China. The primary out...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-12-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2022.2122581 |
| _version_ | 1798014588788146176 |
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| author | Xiaohua Chen Hongyu Wang Jingwen Ai Leer Shen Ke Lin Guanmin Yuan Xiaohua Sheng Xia Jin Zhifeng Deng Jie Xu Guanzhu Lu Shunjie Chen Jianpeng Cai Yi Zhang Haocheng Zhang Sen Wang Wenhong Zhang Cunyi Fan |
| author_facet | Xiaohua Chen Hongyu Wang Jingwen Ai Leer Shen Ke Lin Guanmin Yuan Xiaohua Sheng Xia Jin Zhifeng Deng Jie Xu Guanzhu Lu Shunjie Chen Jianpeng Cai Yi Zhang Haocheng Zhang Sen Wang Wenhong Zhang Cunyi Fan |
| author_sort | Xiaohua Chen |
| collection | DOAJ |
| description | To further describe the effect of the “fragile population” and their “higher-risk” comorbidities on prognosis among hospitalized Omicron patients, this observational cohort study enrolled hospitalized patients confirmed with SARS-CoV-2 during the 2022 Omicron wave in Shanghai, China. The primary outcome was progression to severe or critical cases. The secondary outcome was viral shedding time from the first positive SARS-CoV-2 detection. A total of 847 participants were enrolled, most of whom featured as advanced age (>70 years old: 30.34%), not fully vaccinated (55.84%), combined with at least 1 comorbidity (65.41%). Multivariate cox regression suggested age >70 years old (aHR[95%CI] 0.78[0.61–0.99]), chronic kidney disease (CKD) stage 4–5 (aHR[95%CI] 0.61[0.46–0.80]), heart conditions (aHR[95%CI] 0.76[0.60–0.97]) would elongate viral shedding time and fully/booster vaccination (aHR[95%CI] 1.4 [1.14–1.72]) would shorten this duration. Multivariate logistic regression suggested CKD stage 4–5 (aHR[95%CI] 3.21[1.45–7.27]), cancer (aHR[95%CI] 9.52[4.19–22.61]), and long-term bedridden status (aHR[95%CI] 4.94[2.36–10.44]) were the “higher” risk factor compared with the elderly, heart conditions, metabolic disorders, isolated hypertension, etc. for severity while female (aHR[95%CI] 0.34[0.16–0.68]) and fully/booster Vaccination (aHR[95%CI] 0.35[0.12–0.87]) could provide protection from illness progression. CKD stage 4–5, cancer and long-term bedridden history were “higher-risk” factors among hospitalized Omicron patients for severity progression while full vaccination could provide protection from illness progression. |
| first_indexed | 2024-04-11T15:20:51Z |
| format | Article |
| id | doaj.art-ead9ddf5c20742aaa1d486e096457283 |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2024-04-11T15:20:51Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-ead9ddf5c20742aaa1d486e0964572832022-12-22T04:16:23ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512022-12-011112501250910.1080/22221751.2022.2122581Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-centre cohort studyXiaohua Chen0Hongyu Wang1Jingwen Ai2Leer Shen3Ke Lin4Guanmin Yuan5Xiaohua Sheng6Xia Jin7Zhifeng Deng8Jie Xu9Guanzhu Lu10Shunjie Chen11Jianpeng Cai12Yi Zhang13Haocheng Zhang14Sen Wang15Wenhong Zhang16Cunyi Fan17Department of Infectious Diseases, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of ChinaDepartment of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infectious Diseases, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of ChinaDepartment of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Nephrology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of ChinaShanghai Jiao Tong University Affiliated Sixth People’s Hospital (Lingang District), Shanghai, People’s Republic of ChinaDepartment of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of ChinaShanghai Jiao Tong University Affiliated Ninth People’s Hospital, Shanghai, People’s Republic of ChinaShanghai Jiao Tong University Affiliated Ninth People’s Hospital, Shanghai, People’s Republic of ChinaShanghai Fouth People’s Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of ChinaDepartment of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Infectious Diseases, National Medical Center for Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, Huashan Hospital, Fudan University, Shanghai, People’s Republic of ChinaDepartment of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People’s Republic of ChinaTo further describe the effect of the “fragile population” and their “higher-risk” comorbidities on prognosis among hospitalized Omicron patients, this observational cohort study enrolled hospitalized patients confirmed with SARS-CoV-2 during the 2022 Omicron wave in Shanghai, China. The primary outcome was progression to severe or critical cases. The secondary outcome was viral shedding time from the first positive SARS-CoV-2 detection. A total of 847 participants were enrolled, most of whom featured as advanced age (>70 years old: 30.34%), not fully vaccinated (55.84%), combined with at least 1 comorbidity (65.41%). Multivariate cox regression suggested age >70 years old (aHR[95%CI] 0.78[0.61–0.99]), chronic kidney disease (CKD) stage 4–5 (aHR[95%CI] 0.61[0.46–0.80]), heart conditions (aHR[95%CI] 0.76[0.60–0.97]) would elongate viral shedding time and fully/booster vaccination (aHR[95%CI] 1.4 [1.14–1.72]) would shorten this duration. Multivariate logistic regression suggested CKD stage 4–5 (aHR[95%CI] 3.21[1.45–7.27]), cancer (aHR[95%CI] 9.52[4.19–22.61]), and long-term bedridden status (aHR[95%CI] 4.94[2.36–10.44]) were the “higher” risk factor compared with the elderly, heart conditions, metabolic disorders, isolated hypertension, etc. for severity while female (aHR[95%CI] 0.34[0.16–0.68]) and fully/booster Vaccination (aHR[95%CI] 0.35[0.12–0.87]) could provide protection from illness progression. CKD stage 4–5, cancer and long-term bedridden history were “higher-risk” factors among hospitalized Omicron patients for severity progression while full vaccination could provide protection from illness progression.https://www.tandfonline.com/doi/10.1080/22221751.2022.2122581OmicronSARS-CoV-2COVID-19risk factorshospialized population |
| spellingShingle | Xiaohua Chen Hongyu Wang Jingwen Ai Leer Shen Ke Lin Guanmin Yuan Xiaohua Sheng Xia Jin Zhifeng Deng Jie Xu Guanzhu Lu Shunjie Chen Jianpeng Cai Yi Zhang Haocheng Zhang Sen Wang Wenhong Zhang Cunyi Fan Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-centre cohort study Emerging Microbes and Infections Omicron SARS-CoV-2 COVID-19 risk factors hospialized population |
| title | Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-centre cohort study |
| title_full | Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-centre cohort study |
| title_fullStr | Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-centre cohort study |
| title_full_unstemmed | Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-centre cohort study |
| title_short | Identification of CKD, bedridden history and cancer as higher-risk comorbidities and their impact on prognosis of hospitalized Omicron patients: a multi-centre cohort study |
| title_sort | identification of ckd bedridden history and cancer as higher risk comorbidities and their impact on prognosis of hospitalized omicron patients a multi centre cohort study |
| topic | Omicron SARS-CoV-2 COVID-19 risk factors hospialized population |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2022.2122581 |
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