Altered Spontaneous Brain Activity and Network Property in Patients With Congenital Monocular Blindness
Individuals with congenital monocular blindness may have specific brain changes since the brain is prenatally deprived of half the normal visual input. To explore characteristic brain functional changes of congenital monocular blindness, we analyzed resting-state functional MRI (rs-fMRI) data of 16...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.789655/full |
| _version_ | 1819279431691141120 |
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| author | Jingwen Ding Xiaoxia Qu Jing Cui Jie Dong Jian Guo Junfang Xian Dongmei Li |
| author_facet | Jingwen Ding Xiaoxia Qu Jing Cui Jie Dong Jian Guo Junfang Xian Dongmei Li |
| author_sort | Jingwen Ding |
| collection | DOAJ |
| description | Individuals with congenital monocular blindness may have specific brain changes since the brain is prenatally deprived of half the normal visual input. To explore characteristic brain functional changes of congenital monocular blindness, we analyzed resting-state functional MRI (rs-fMRI) data of 16 patients with unilateral congenital microphthalmia and 16 healthy subjects with normal vision to compare intergroup differences of amplitude of low frequency fluctuations (ALFFs), functional connectivity (FC), and network topolgoical properties. Compared with controls, patients with microphthalmia exhibited significantly lower ALFF values in the left inferior occipital and temporal gyri, superior temporal gyrus, inferior parietal lobe and post-central gyrus, whereas higher ALFF in the right middle and inferior temporal gyri, middle and superior frontal gyri, left superior frontal, and temporal gyri, such as angular gyrus. Meanwhile, FC between left medial superior frontal gyrus and angular gyrus, FC between left superior temporal gyrus and inferior parietal lobe and post-central gyrus decreased in the patients with congenital microphthalmia. In addition, a graph theory-analysis revealed increased regional network metrics (degree centrality and nodal efficiency) in the middle and inferior temporal gyri and middle and superior frontal gyri, while decreased values in the inferior occipital and temporal gyri, inferior parietal lobule, post-central gyrus, and angular gyrus. Taken together, patients with congenital microphthalmia had widespread abnormal activities within neural networks involving the vision and language and language-related regions played dominant roles in their brain networks. These findings may provide clues for functional reorganization of vision and language networks induced by the congenital monocular blindness. |
| first_indexed | 2024-12-24T00:27:48Z |
| format | Article |
| id | doaj.art-eadaa309bb034d5b8f1ef5a887646901 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-24T00:27:48Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-eadaa309bb034d5b8f1ef5a8876469012022-12-21T17:24:24ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-02-011310.3389/fneur.2022.789655789655Altered Spontaneous Brain Activity and Network Property in Patients With Congenital Monocular BlindnessJingwen Ding0Xiaoxia Qu1Jing Cui2Jie Dong3Jian Guo4Junfang Xian5Dongmei Li6Beijing Ophthalmology & Visual Science Key Lab, Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaBeijing Ophthalmology & Visual Science Key Lab, Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaBeijing Ophthalmology & Visual Science Key Lab, Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaIndividuals with congenital monocular blindness may have specific brain changes since the brain is prenatally deprived of half the normal visual input. To explore characteristic brain functional changes of congenital monocular blindness, we analyzed resting-state functional MRI (rs-fMRI) data of 16 patients with unilateral congenital microphthalmia and 16 healthy subjects with normal vision to compare intergroup differences of amplitude of low frequency fluctuations (ALFFs), functional connectivity (FC), and network topolgoical properties. Compared with controls, patients with microphthalmia exhibited significantly lower ALFF values in the left inferior occipital and temporal gyri, superior temporal gyrus, inferior parietal lobe and post-central gyrus, whereas higher ALFF in the right middle and inferior temporal gyri, middle and superior frontal gyri, left superior frontal, and temporal gyri, such as angular gyrus. Meanwhile, FC between left medial superior frontal gyrus and angular gyrus, FC between left superior temporal gyrus and inferior parietal lobe and post-central gyrus decreased in the patients with congenital microphthalmia. In addition, a graph theory-analysis revealed increased regional network metrics (degree centrality and nodal efficiency) in the middle and inferior temporal gyri and middle and superior frontal gyri, while decreased values in the inferior occipital and temporal gyri, inferior parietal lobule, post-central gyrus, and angular gyrus. Taken together, patients with congenital microphthalmia had widespread abnormal activities within neural networks involving the vision and language and language-related regions played dominant roles in their brain networks. These findings may provide clues for functional reorganization of vision and language networks induced by the congenital monocular blindness.https://www.frontiersin.org/articles/10.3389/fneur.2022.789655/fullmonocular blindnesscongenital microphthalmiaresting-state functional MRIamplitude of low frequency fluctuationbrain network |
| spellingShingle | Jingwen Ding Xiaoxia Qu Jing Cui Jie Dong Jian Guo Junfang Xian Dongmei Li Altered Spontaneous Brain Activity and Network Property in Patients With Congenital Monocular Blindness Frontiers in Neurology monocular blindness congenital microphthalmia resting-state functional MRI amplitude of low frequency fluctuation brain network |
| title | Altered Spontaneous Brain Activity and Network Property in Patients With Congenital Monocular Blindness |
| title_full | Altered Spontaneous Brain Activity and Network Property in Patients With Congenital Monocular Blindness |
| title_fullStr | Altered Spontaneous Brain Activity and Network Property in Patients With Congenital Monocular Blindness |
| title_full_unstemmed | Altered Spontaneous Brain Activity and Network Property in Patients With Congenital Monocular Blindness |
| title_short | Altered Spontaneous Brain Activity and Network Property in Patients With Congenital Monocular Blindness |
| title_sort | altered spontaneous brain activity and network property in patients with congenital monocular blindness |
| topic | monocular blindness congenital microphthalmia resting-state functional MRI amplitude of low frequency fluctuation brain network |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.789655/full |
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