Medulloblastoma in a calf of the flemish breed
Medulloblastomas are neuroectodermal tumors of embryonic origin developing in cerebellum and spinal cord and have an unusual occurrence. When occurs in cattle, it is observed in neonatal cases, leading to multiple neurological clinical signs. Flemish cattle are considered at risk of extinction and t...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Universidade Estadual de Londrina
2019-05-01
|
Series: | Semina: Ciências Agrárias |
Subjects: | |
Online Access: | http://www.uel.br/revistas/uel/index.php/semagrarias/article/view/33545 |
_version_ | 1818516531224510464 |
---|---|
author | Thierry Grima de Cristo Maicon Gaissler Lorena Pinto Thais Coelho Valente Ana Karina Couto Hack Joandes Henrique Fonteque Natalia Coelho Couto de Azevedo Fernandes Cinthya dos Santos Cirqueira Borges Renata Assis Casagrande |
author_facet | Thierry Grima de Cristo Maicon Gaissler Lorena Pinto Thais Coelho Valente Ana Karina Couto Hack Joandes Henrique Fonteque Natalia Coelho Couto de Azevedo Fernandes Cinthya dos Santos Cirqueira Borges Renata Assis Casagrande |
author_sort | Thierry Grima de Cristo |
collection | DOAJ |
description | Medulloblastomas are neuroectodermal tumors of embryonic origin developing in cerebellum and spinal cord and have an unusual occurrence. When occurs in cattle, it is observed in neonatal cases, leading to multiple neurological clinical signs. Flemish cattle are considered at risk of extinction and the rare specimens of Brazil are in Lages, Santa Catarina. The case of a two-month-old calf with difficulty to remain in a standing position, imbalance, opisthotonus, strabismus, and broad-based gait is described in this study. The animal was euthanized and the necropsy showed an irregular, whitish pink, and friable mass in the cerebellar vermis region, measuring 5×6×3.8 cm associated with the dilation of the lateral ventricles, which extended through the interventricular foramen, midbrain aqueduct, and fourth ventricle. Histologically, it presented elongated triangular neuronal cells arranged in a dense sheet that sometimes encircled small areas of neuropil to form Homer-Wright pseudorosettes. These tumor characteristics were compatible with a medulloblastoma. The immunohistochemical (IHC) evaluation of the tumor demonstrated a positive staining for vimentin in neoplastic cells and glial fibrillary acidic protein in neoplastic stromal cells, non-reactive for synaptophysin, and negative for S100 protein and pan-cytokeratin. The histological and topographical characteristics were paramount for determining the medulloblastoma diagnosis and the IHC panel is similar to that observed in other studies. Tumor growth is limited by skull bony structures, allowing determining that the clinical signs expressed by the animal were directly related to the compression of important functional structures due to tumor expansion. Medulloblastoma is an unusual tumor in all animal species, not previously reported in Flemish cattle, and necropsy followed by histopathological examination is essential for diagnosis. |
first_indexed | 2024-12-11T00:43:30Z |
format | Article |
id | doaj.art-eadb42d29da04c698cb7da56ee6b6598 |
institution | Directory Open Access Journal |
issn | 1676-546X 1679-0359 |
language | English |
last_indexed | 2024-12-11T00:43:30Z |
publishDate | 2019-05-01 |
publisher | Universidade Estadual de Londrina |
record_format | Article |
series | Semina: Ciências Agrárias |
spelling | doaj.art-eadb42d29da04c698cb7da56ee6b65982022-12-22T01:26:50ZengUniversidade Estadual de LondrinaSemina: Ciências Agrárias1676-546X1679-03592019-05-014031365137210.5433/1679-0359.2019v40n3p136518568Medulloblastoma in a calf of the flemish breedThierry Grima de Cristo0Maicon Gaissler Lorena Pinto1Thais Coelho Valente2Ana Karina Couto Hack3Joandes Henrique Fonteque4Natalia Coelho Couto de Azevedo Fernandes5Cinthya dos Santos Cirqueira Borges6Renata Assis Casagrande7Universidade do Estado de Santa CatarinaEmpresa de Pesquisa Agropecuária e Extensão Rural de Santa CatarinaUniversidade do Estado de Santa CatarinaUniversidade do Estado de Santa CatarinaUniversidade do Estado de Santa CatarinaCentro de Patologia do Instituto Adolfo LutzCentro de Patologia do Instituto Adolfo LutzUniversidade do Estado de Santa CatarinaMedulloblastomas are neuroectodermal tumors of embryonic origin developing in cerebellum and spinal cord and have an unusual occurrence. When occurs in cattle, it is observed in neonatal cases, leading to multiple neurological clinical signs. Flemish cattle are considered at risk of extinction and the rare specimens of Brazil are in Lages, Santa Catarina. The case of a two-month-old calf with difficulty to remain in a standing position, imbalance, opisthotonus, strabismus, and broad-based gait is described in this study. The animal was euthanized and the necropsy showed an irregular, whitish pink, and friable mass in the cerebellar vermis region, measuring 5×6×3.8 cm associated with the dilation of the lateral ventricles, which extended through the interventricular foramen, midbrain aqueduct, and fourth ventricle. Histologically, it presented elongated triangular neuronal cells arranged in a dense sheet that sometimes encircled small areas of neuropil to form Homer-Wright pseudorosettes. These tumor characteristics were compatible with a medulloblastoma. The immunohistochemical (IHC) evaluation of the tumor demonstrated a positive staining for vimentin in neoplastic cells and glial fibrillary acidic protein in neoplastic stromal cells, non-reactive for synaptophysin, and negative for S100 protein and pan-cytokeratin. The histological and topographical characteristics were paramount for determining the medulloblastoma diagnosis and the IHC panel is similar to that observed in other studies. Tumor growth is limited by skull bony structures, allowing determining that the clinical signs expressed by the animal were directly related to the compression of important functional structures due to tumor expansion. Medulloblastoma is an unusual tumor in all animal species, not previously reported in Flemish cattle, and necropsy followed by histopathological examination is essential for diagnosis.http://www.uel.br/revistas/uel/index.php/semagrarias/article/view/33545NeoplasiaNeuropatologiaSistema nervoso centralRuminante. |
spellingShingle | Thierry Grima de Cristo Maicon Gaissler Lorena Pinto Thais Coelho Valente Ana Karina Couto Hack Joandes Henrique Fonteque Natalia Coelho Couto de Azevedo Fernandes Cinthya dos Santos Cirqueira Borges Renata Assis Casagrande Medulloblastoma in a calf of the flemish breed Semina: Ciências Agrárias Neoplasia Neuropatologia Sistema nervoso central Ruminante. |
title | Medulloblastoma in a calf of the flemish breed |
title_full | Medulloblastoma in a calf of the flemish breed |
title_fullStr | Medulloblastoma in a calf of the flemish breed |
title_full_unstemmed | Medulloblastoma in a calf of the flemish breed |
title_short | Medulloblastoma in a calf of the flemish breed |
title_sort | medulloblastoma in a calf of the flemish breed |
topic | Neoplasia Neuropatologia Sistema nervoso central Ruminante. |
url | http://www.uel.br/revistas/uel/index.php/semagrarias/article/view/33545 |
work_keys_str_mv | AT thierrygrimadecristo medulloblastomainacalfoftheflemishbreed AT maicongaisslerlorenapinto medulloblastomainacalfoftheflemishbreed AT thaiscoelhovalente medulloblastomainacalfoftheflemishbreed AT anakarinacoutohack medulloblastomainacalfoftheflemishbreed AT joandeshenriquefonteque medulloblastomainacalfoftheflemishbreed AT nataliacoelhocoutodeazevedofernandes medulloblastomainacalfoftheflemishbreed AT cinthyadossantoscirqueiraborges medulloblastomainacalfoftheflemishbreed AT renataassiscasagrande medulloblastomainacalfoftheflemishbreed |