The Bond Strength and Antibacterial Activity of the Universal Dentin Bonding System: A Systematic Review and Meta-Analysis
<i>Streptococcus mutans</i> (<i>S. mutans</i>) is a group of viridans mostly located in oral flora among the wide and biodiverse biofilm. It plays a significant role not only in caries formation but also triggering intracerebral haemorrhage. The durable and stable bond interf...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/6/1230 |
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| author | Louis Hardan Rim Bourgi Carlos Enrique Cuevas-Suárez Maciej Zarow Naji Kharouf Davide Mancino Carlos Fernández Villares Dariusz Skaba Monika Lukomska-Szymanska |
| author_facet | Louis Hardan Rim Bourgi Carlos Enrique Cuevas-Suárez Maciej Zarow Naji Kharouf Davide Mancino Carlos Fernández Villares Dariusz Skaba Monika Lukomska-Szymanska |
| author_sort | Louis Hardan |
| collection | DOAJ |
| description | <i>Streptococcus mutans</i> (<i>S. mutans</i>) is a group of viridans mostly located in oral flora among the wide and biodiverse biofilm. It plays a significant role not only in caries formation but also triggering intracerebral haemorrhage. The durable and stable bond interface, besides bacteria elimination, is one of the crucial factors influencing the resin composite restoration performance. This study aimed to evaluate universal adhesives (UAs) with regard to in vitro bond strength to dentin, and the inhibition of the <i>S. mutans</i> growth and compare them with UAs modified with antimicrobial agents through a systematic review and meta-analysis. Two reviewers performed a literature search up to April 2021 in 5 electronic databases: PubMed MedLine, Scielo, ISI Web of Science, Scopus, and EMBASE. Only in vitro studies reporting the effect of modifying UAs with antimicrobial agents on the bond strength to dentin and/or on the inhibition of the <i>S. mutans</i> were included. Analyses were carried out using Review Manager Software version 5.3.5 (The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark). The methodological quality of each in vitro study was evaluated following the parameters of a previous systematic review. A total of 1716 potentially relevant publications were recognized. After reviewing the title and abstract, 16 studies remained in the systematic review. From these, a total of 3 studies were included in the meta-analysis. Since data from the studies included in the antimicrobial outcome included zero values, they could not be meta-analysed. Including 0 values in the analysis will lead to several biases in the analysis, so these data were discarded. The antibacterial effect against <i>S. mutans</i> of UAs modified with antimicrobial agents was higher than the non-modified adhesive systems. Within the limitations of the present study, the bond strength of UAs to dentin could be improved by using antimicrobial agents. The UAs modified with antibacterial agents showed a decrease in the viability of <i>S. mutans</i> biofilm, among the adhesives tested. However, there are not enough valid data on antibacterial properties of modified UAs; therefore, more well-designed research on these materials is needed. |
| first_indexed | 2024-03-10T10:40:31Z |
| format | Article |
| id | doaj.art-eadca4fe1dea4d07ad1262c546f3357d |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T10:40:31Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-eadca4fe1dea4d07ad1262c546f3357d2023-11-21T23:00:45ZengMDPI AGMicroorganisms2076-26072021-06-0196123010.3390/microorganisms9061230The Bond Strength and Antibacterial Activity of the Universal Dentin Bonding System: A Systematic Review and Meta-AnalysisLouis Hardan0Rim Bourgi1Carlos Enrique Cuevas-Suárez2Maciej Zarow3Naji Kharouf4Davide Mancino5Carlos Fernández Villares6Dariusz Skaba7Monika Lukomska-Szymanska8Department of Restorative Dentistry, School of Dentistry, Saint-Joseph University, Beirut 1107 2180, LebanonDepartment of Restorative Dentistry, School of Dentistry, Saint-Joseph University, Beirut 1107 2180, LebanonDental Materials Laboratory, Academic Area of Dentistry, Autonomous University of Hidalgo State, Circuito Ex Hacienda La Concepción S/N, San Agustín Tlaxiaca 42160, MexicoPrivate Practice, “NZOZ SPS Dentist” Dental Clinic and Postgraduate Course Centre—pl. Inwalidow 7/5, 30-033 Cracow, PolandDepartment of Biomaterials and Bioengineering, INSERM UMR_S 1121, Biomaterials and Bioengineering, 67000 Strasbourg, FranceDepartment of Biomaterials and Bioengineering, INSERM UMR_S 1121, Biomaterials and Bioengineering, 67000 Strasbourg, FrancePrivate Practice, Cipriano Sancho, 11 Madrid, 28017 Madrid, SpainDepartment of Periodontal Diseases and Oral Mucosa Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, PolandDepartment of General Dentistry, Medical University of Lodz, 251 Pomorska St., 92-213 Lodz, Poland<i>Streptococcus mutans</i> (<i>S. mutans</i>) is a group of viridans mostly located in oral flora among the wide and biodiverse biofilm. It plays a significant role not only in caries formation but also triggering intracerebral haemorrhage. The durable and stable bond interface, besides bacteria elimination, is one of the crucial factors influencing the resin composite restoration performance. This study aimed to evaluate universal adhesives (UAs) with regard to in vitro bond strength to dentin, and the inhibition of the <i>S. mutans</i> growth and compare them with UAs modified with antimicrobial agents through a systematic review and meta-analysis. Two reviewers performed a literature search up to April 2021 in 5 electronic databases: PubMed MedLine, Scielo, ISI Web of Science, Scopus, and EMBASE. Only in vitro studies reporting the effect of modifying UAs with antimicrobial agents on the bond strength to dentin and/or on the inhibition of the <i>S. mutans</i> were included. Analyses were carried out using Review Manager Software version 5.3.5 (The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen, Denmark). The methodological quality of each in vitro study was evaluated following the parameters of a previous systematic review. A total of 1716 potentially relevant publications were recognized. After reviewing the title and abstract, 16 studies remained in the systematic review. From these, a total of 3 studies were included in the meta-analysis. Since data from the studies included in the antimicrobial outcome included zero values, they could not be meta-analysed. Including 0 values in the analysis will lead to several biases in the analysis, so these data were discarded. The antibacterial effect against <i>S. mutans</i> of UAs modified with antimicrobial agents was higher than the non-modified adhesive systems. Within the limitations of the present study, the bond strength of UAs to dentin could be improved by using antimicrobial agents. The UAs modified with antibacterial agents showed a decrease in the viability of <i>S. mutans</i> biofilm, among the adhesives tested. However, there are not enough valid data on antibacterial properties of modified UAs; therefore, more well-designed research on these materials is needed.https://www.mdpi.com/2076-2607/9/6/1230antibacterial agentsantibacterial propertiesbond strengthdentinuniversal adhesives |
| spellingShingle | Louis Hardan Rim Bourgi Carlos Enrique Cuevas-Suárez Maciej Zarow Naji Kharouf Davide Mancino Carlos Fernández Villares Dariusz Skaba Monika Lukomska-Szymanska The Bond Strength and Antibacterial Activity of the Universal Dentin Bonding System: A Systematic Review and Meta-Analysis Microorganisms antibacterial agents antibacterial properties bond strength dentin universal adhesives |
| title | The Bond Strength and Antibacterial Activity of the Universal Dentin Bonding System: A Systematic Review and Meta-Analysis |
| title_full | The Bond Strength and Antibacterial Activity of the Universal Dentin Bonding System: A Systematic Review and Meta-Analysis |
| title_fullStr | The Bond Strength and Antibacterial Activity of the Universal Dentin Bonding System: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Bond Strength and Antibacterial Activity of the Universal Dentin Bonding System: A Systematic Review and Meta-Analysis |
| title_short | The Bond Strength and Antibacterial Activity of the Universal Dentin Bonding System: A Systematic Review and Meta-Analysis |
| title_sort | bond strength and antibacterial activity of the universal dentin bonding system a systematic review and meta analysis |
| topic | antibacterial agents antibacterial properties bond strength dentin universal adhesives |
| url | https://www.mdpi.com/2076-2607/9/6/1230 |
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