Basedow’s disease with associated features of Hashimoto’s thyroiditis based on histopathological findings
Abstract Background Basedow’s disease and Hashimoto’s thyroiditis are autoimmune thyroid disorders and usually diagnosed with elevation of serum autoimmune antibodies. Thyrotropin receptor antibodies (TRAb) and/or thyroid-stimulating antibody (TSAb) are usually used for diagnosis of Basedow’s diseas...
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-08-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12902-020-00602-8 |
| _version_ | 1818337023164940288 |
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| author | Megumi Horiya Takatoshi Anno Fumiko Kawasaki Yuichiro Iwamoto Shintaro Irie Yasumasa Monobe Koichi Tomoda Kohei Kaku Shuhei Nakanishi Hideaki Kaneto |
| author_facet | Megumi Horiya Takatoshi Anno Fumiko Kawasaki Yuichiro Iwamoto Shintaro Irie Yasumasa Monobe Koichi Tomoda Kohei Kaku Shuhei Nakanishi Hideaki Kaneto |
| author_sort | Megumi Horiya |
| collection | DOAJ |
| description | Abstract Background Basedow’s disease and Hashimoto’s thyroiditis are autoimmune thyroid disorders and usually diagnosed with elevation of serum autoimmune antibodies. Thyrotropin receptor antibodies (TRAb) and/or thyroid-stimulating antibody (TSAb) are usually used for diagnosis of Basedow’s disease, and thyroid peroxidase antibodies (TPOAb) and/or thyroglobulin antibodies (TgAb) are for diagnosis of Hashimoto’s thyroiditis. However, it is difficult to diagnose a subject as Basedow’s disease with associated features of Hashimoto’s thyroiditis only with elevation of such autoimmune antibodies. Case presentation A 44-year-old woman with 5-year history of Basedow’s disease underwent a total thyroidectomy. She did not have a goiter. TRAb, TSAb, TPOAg and TgAb were all positive before a total thyroidectomy. In histopathological macroscopic examination, diffuse hyperplasia of the thyroid gland was observed. Furthermore, in histopathological microscopic examination, both characteristics of Basedow’s disease and Hashimoto’s thyroiditis were observed. After a total thyroidectomy, titers of all thyroid-associated autoimmune antibodies were markedly reduced. Conclusion Herein, we report a subject with Basedow’s disease without a goiter whose TPOAb and TgAb were relatively high at the onset of Basedow’s disease. In addition, interestingly, the histopathological findings of this subject showed direct signs of Basedow’s disease and Hashimoto’s thyroiditis in the same thyroid gland. Considering from such findings, she seemed to have Basedow’s disease with associated features of Hashimoto’s thyroiditis. In conclusion, we should bear in mind the possibility of Basedow’s disease with associated features of Hashimoto’s thyroiditis in subjects with Basedow’s disease, particularly when TPOAb and TgAb as well as TRAb and TSAb are positive. |
| first_indexed | 2024-12-13T14:48:37Z |
| format | Article |
| id | doaj.art-eadcecd1e0d14dae9d1fc1f257c297d0 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-12-13T14:48:37Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-eadcecd1e0d14dae9d1fc1f257c297d02022-12-21T23:41:25ZengBMCBMC Endocrine Disorders1472-68232020-08-012011710.1186/s12902-020-00602-8Basedow’s disease with associated features of Hashimoto’s thyroiditis based on histopathological findingsMegumi Horiya0Takatoshi Anno1Fumiko Kawasaki2Yuichiro Iwamoto3Shintaro Irie4Yasumasa Monobe5Koichi Tomoda6Kohei Kaku7Shuhei Nakanishi8Hideaki Kaneto9Department of General Internal Medicine 1, Kawasaki Medical SchoolDepartment of General Internal Medicine 1, Kawasaki Medical SchoolDepartment of General Internal Medicine 1, Kawasaki Medical SchoolDepartment of General Internal Medicine 1, Kawasaki Medical SchoolDepartment of General Internal Medicine 1, Kawasaki Medical SchoolDepartment of Pathology, Kawasaki Medical SchoolDepartment of General Internal Medicine 1, Kawasaki Medical SchoolDepartment of General Internal Medicine 1, Kawasaki Medical SchoolDepartment of Diabetes, Metabolism and Endocrinology, Kawasaki Medical SchoolDepartment of Diabetes, Metabolism and Endocrinology, Kawasaki Medical SchoolAbstract Background Basedow’s disease and Hashimoto’s thyroiditis are autoimmune thyroid disorders and usually diagnosed with elevation of serum autoimmune antibodies. Thyrotropin receptor antibodies (TRAb) and/or thyroid-stimulating antibody (TSAb) are usually used for diagnosis of Basedow’s disease, and thyroid peroxidase antibodies (TPOAb) and/or thyroglobulin antibodies (TgAb) are for diagnosis of Hashimoto’s thyroiditis. However, it is difficult to diagnose a subject as Basedow’s disease with associated features of Hashimoto’s thyroiditis only with elevation of such autoimmune antibodies. Case presentation A 44-year-old woman with 5-year history of Basedow’s disease underwent a total thyroidectomy. She did not have a goiter. TRAb, TSAb, TPOAg and TgAb were all positive before a total thyroidectomy. In histopathological macroscopic examination, diffuse hyperplasia of the thyroid gland was observed. Furthermore, in histopathological microscopic examination, both characteristics of Basedow’s disease and Hashimoto’s thyroiditis were observed. After a total thyroidectomy, titers of all thyroid-associated autoimmune antibodies were markedly reduced. Conclusion Herein, we report a subject with Basedow’s disease without a goiter whose TPOAb and TgAb were relatively high at the onset of Basedow’s disease. In addition, interestingly, the histopathological findings of this subject showed direct signs of Basedow’s disease and Hashimoto’s thyroiditis in the same thyroid gland. Considering from such findings, she seemed to have Basedow’s disease with associated features of Hashimoto’s thyroiditis. In conclusion, we should bear in mind the possibility of Basedow’s disease with associated features of Hashimoto’s thyroiditis in subjects with Basedow’s disease, particularly when TPOAb and TgAb as well as TRAb and TSAb are positive.http://link.springer.com/article/10.1186/s12902-020-00602-8Basedow’s diseaseHashimoto’s thyroiditisHistopathological featuresAutoimmune antibody |
| spellingShingle | Megumi Horiya Takatoshi Anno Fumiko Kawasaki Yuichiro Iwamoto Shintaro Irie Yasumasa Monobe Koichi Tomoda Kohei Kaku Shuhei Nakanishi Hideaki Kaneto Basedow’s disease with associated features of Hashimoto’s thyroiditis based on histopathological findings BMC Endocrine Disorders Basedow’s disease Hashimoto’s thyroiditis Histopathological features Autoimmune antibody |
| title | Basedow’s disease with associated features of Hashimoto’s thyroiditis based on histopathological findings |
| title_full | Basedow’s disease with associated features of Hashimoto’s thyroiditis based on histopathological findings |
| title_fullStr | Basedow’s disease with associated features of Hashimoto’s thyroiditis based on histopathological findings |
| title_full_unstemmed | Basedow’s disease with associated features of Hashimoto’s thyroiditis based on histopathological findings |
| title_short | Basedow’s disease with associated features of Hashimoto’s thyroiditis based on histopathological findings |
| title_sort | basedow s disease with associated features of hashimoto s thyroiditis based on histopathological findings |
| topic | Basedow’s disease Hashimoto’s thyroiditis Histopathological features Autoimmune antibody |
| url | http://link.springer.com/article/10.1186/s12902-020-00602-8 |
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