Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development

Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development

Abstract Background Cancer results from the accumulation of mutations leading to the acquisition of cancer promoting characteristics such as increased proliferation and resistance to cell death. In colorectal cancer, an early mutation leading to such features usually occurs in the APC or CTNNB1 gene...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Ronja S. Adam, Sanne M. van Neerven, Cayetano Pleguezuelos-Manzano, Salvatore Simmini, Nicolas Léveillé, Nina E. de Groot, Andrew N. Holding, Florian Markowetz, Louis Vermeulen
Format: Artikel
Sprache:English
Veröffentlicht: BMC 2020-12-01
Schriftenreihe:Cancer Cell International
Schlagworte:
Intestinal cancer
Wnt signalling
Cell of origin
Online Zugang:https://doi.org/10.1186/s12935-020-01661-6

Online

https://doi.org/10.1186/s12935-020-01661-6

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