A Multi-institutional Study of Prevalence and Clinicopathologic Features of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) in Korea
Background In the present multi-institutional study, the prevalence and clinicopathologic characteristics of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) were evaluated among Korean patients who underwent thyroidectomy for papillary thyroid carcinoma (PTC). M...
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| Format: | Article |
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Korean Society of Pathologists & the Korean Society for Cytopathology
2019-11-01
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| Series: | Journal of Pathology and Translational Medicine |
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| Online Access: | http://www.jpatholtm.org/upload/pdf/jptm-2019-09-18.pdf |
| _version_ | 1818827497651830784 |
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| author | Ja Yeong Seo Ji Hyun Park Ju Yeon Pyo Yoon Jin Cha Chan Kwon Jung Dong Eun Song Jeong Ja Kwak So Yeon Park Hee Young Na Jang-Hee Kim Jae Yeon Seok Hee Sung Kim Soon Won Hong |
| author_facet | Ja Yeong Seo Ji Hyun Park Ju Yeon Pyo Yoon Jin Cha Chan Kwon Jung Dong Eun Song Jeong Ja Kwak So Yeon Park Hee Young Na Jang-Hee Kim Jae Yeon Seok Hee Sung Kim Soon Won Hong |
| author_sort | Ja Yeong Seo |
| collection | DOAJ |
| description | Background In the present multi-institutional study, the prevalence and clinicopathologic characteristics of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) were evaluated among Korean patients who underwent thyroidectomy for papillary thyroid carcinoma (PTC). Methods Data from 18,819 patients with PTC from eight university hospitals between January 2012 and February 2018 were retrospectively evaluated. Pathology reports of all PTCs and slides of potential NIFTP cases were reviewed. The strict criterion of no papillae was applied for the diagnosis of NIFTP. Due to assumptions regarding misclassification of NIFTP as non-PTC tumors, the lower boundary of NIFTP prevalence among PTCs was estimated. Mutational analysis for BRAF and three RAS isoforms was performed in 27 randomly selected NIFTP cases. Results The prevalence of NIFTP was 1.3% (238/18,819) of all PTCs when the same histologic criteria were applied for NIFTP regardless of the tumor size but decreased to 0.8% (152/18,819) when tumors ≥1 cm in size were included. The mean follow-up was 37.7 months and no patient with NIFTP had evidence of lymph node metastasis, distant metastasis, or disease recurrence during the follow-up period. A difference in prevalence of NIFTP before and after NIFTP introduction was not observed. BRAFV600E mutation was not found in NIFTP. The mutation rate for the three RAS genes was 55.6% (15/27). Conclusions The low prevalence and indolent clinical outcome of NIFTP in Korea was confirmed using the largest number of cases to date. The introduction of NIFTP may have a small overall impact in Korean practice. |
| first_indexed | 2024-12-19T00:44:30Z |
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| id | doaj.art-eadddbd4b01f4099a97989d58e1aad6b |
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| issn | 2383-7837 2383-7845 |
| language | English |
| last_indexed | 2024-12-19T00:44:30Z |
| publishDate | 2019-11-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
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| series | Journal of Pathology and Translational Medicine |
| spelling | doaj.art-eadddbd4b01f4099a97989d58e1aad6b2022-12-21T20:44:20ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452019-11-0153637838510.4132/jptm.2019.09.1816868A Multi-institutional Study of Prevalence and Clinicopathologic Features of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) in KoreaJa Yeong Seo0Ji Hyun Park1Ju Yeon Pyo2Yoon Jin Cha3Chan Kwon Jung4Dong Eun Song5Jeong Ja Kwak6So Yeon Park7Hee Young Na8Jang-Hee Kim9Jae Yeon Seok10Hee Sung Kim11Soon Won Hong Department of Pathology, Thyroid Cancer Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea Department of Pathology, Thyroid Cancer Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea Department of Pathology, Thyroid Cancer Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea Department of Pathology, Thyroid Cancer Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea Department of Hospital Pathology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Pathology, Soonchunhyang University College of Medicine, Bucheon, Korea Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea Department of Pathology, Ajou University School of Medicine, Suwon, Korea Department of Pathology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea Department of Pathology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, KoreaBackground In the present multi-institutional study, the prevalence and clinicopathologic characteristics of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) were evaluated among Korean patients who underwent thyroidectomy for papillary thyroid carcinoma (PTC). Methods Data from 18,819 patients with PTC from eight university hospitals between January 2012 and February 2018 were retrospectively evaluated. Pathology reports of all PTCs and slides of potential NIFTP cases were reviewed. The strict criterion of no papillae was applied for the diagnosis of NIFTP. Due to assumptions regarding misclassification of NIFTP as non-PTC tumors, the lower boundary of NIFTP prevalence among PTCs was estimated. Mutational analysis for BRAF and three RAS isoforms was performed in 27 randomly selected NIFTP cases. Results The prevalence of NIFTP was 1.3% (238/18,819) of all PTCs when the same histologic criteria were applied for NIFTP regardless of the tumor size but decreased to 0.8% (152/18,819) when tumors ≥1 cm in size were included. The mean follow-up was 37.7 months and no patient with NIFTP had evidence of lymph node metastasis, distant metastasis, or disease recurrence during the follow-up period. A difference in prevalence of NIFTP before and after NIFTP introduction was not observed. BRAFV600E mutation was not found in NIFTP. The mutation rate for the three RAS genes was 55.6% (15/27). Conclusions The low prevalence and indolent clinical outcome of NIFTP in Korea was confirmed using the largest number of cases to date. The introduction of NIFTP may have a small overall impact in Korean practice.http://www.jpatholtm.org/upload/pdf/jptm-2019-09-18.pdfthyroid carcinomafollicular variantpapillary carcinomanon-invasive follicular thyroid neoplasm with papillary-like nuclear features |
| spellingShingle | Ja Yeong Seo Ji Hyun Park Ju Yeon Pyo Yoon Jin Cha Chan Kwon Jung Dong Eun Song Jeong Ja Kwak So Yeon Park Hee Young Na Jang-Hee Kim Jae Yeon Seok Hee Sung Kim Soon Won Hong A Multi-institutional Study of Prevalence and Clinicopathologic Features of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) in Korea Journal of Pathology and Translational Medicine thyroid carcinoma follicular variant papillary carcinoma non-invasive follicular thyroid neoplasm with papillary-like nuclear features |
| title | A Multi-institutional Study of Prevalence and Clinicopathologic Features of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) in Korea |
| title_full | A Multi-institutional Study of Prevalence and Clinicopathologic Features of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) in Korea |
| title_fullStr | A Multi-institutional Study of Prevalence and Clinicopathologic Features of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) in Korea |
| title_full_unstemmed | A Multi-institutional Study of Prevalence and Clinicopathologic Features of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) in Korea |
| title_short | A Multi-institutional Study of Prevalence and Clinicopathologic Features of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP) in Korea |
| title_sort | multi institutional study of prevalence and clinicopathologic features of non invasive follicular thyroid neoplasm with papillary like nuclear features niftp in korea |
| topic | thyroid carcinoma follicular variant papillary carcinoma non-invasive follicular thyroid neoplasm with papillary-like nuclear features |
| url | http://www.jpatholtm.org/upload/pdf/jptm-2019-09-18.pdf |
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