Asperaculanes A and B, Two Sesquiterpenoids from the Fungus Aspergillus aculeatus
Six sesquiterpenoids 1–6, including two new ones, an ent-daucane-type sesquiterpenoid, asperaculane A (1), and a nordaucane one, asperaculane B (2), and four known nordaucane derivatives, aculenes A–D 3–6, together with the known secalonic acid D (7), were isolated from a fermentation culture of the...
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MDPI AG
2014-12-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/20/1/325 |
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| author | Yu-Qi Gao Chun-Jun Guo Qiang Zhang Wen-Ming Zhou Clay C. C. Wang Jin-Ming Gao |
| author_facet | Yu-Qi Gao Chun-Jun Guo Qiang Zhang Wen-Ming Zhou Clay C. C. Wang Jin-Ming Gao |
| author_sort | Yu-Qi Gao |
| collection | DOAJ |
| description | Six sesquiterpenoids 1–6, including two new ones, an ent-daucane-type sesquiterpenoid, asperaculane A (1), and a nordaucane one, asperaculane B (2), and four known nordaucane derivatives, aculenes A–D 3–6, together with the known secalonic acid D (7), were isolated from a fermentation culture of the fungus Aspergillus aculeatus. Their structures and absolute configurations were established by analyses of their spectroscopic data, including 1D and 2D-NMR spectra, HR-ESIMS, electronic circular dichroism (ECD) data, and quantum chemical calculations. These metabolites were evaluated for in vitro cytotoxic activity against two cell lines, human cancer cell lines (HeLa) and one normal hamster cell line (CHO). |
| first_indexed | 2024-12-21T16:25:20Z |
| format | Article |
| id | doaj.art-eade871aec1846ecb2dbf380cf223a37 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-21T16:25:20Z |
| publishDate | 2014-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-eade871aec1846ecb2dbf380cf223a372022-12-21T18:57:28ZengMDPI AGMolecules1420-30492014-12-0120132533410.3390/molecules20010325molecules20010325Asperaculanes A and B, Two Sesquiterpenoids from the Fungus Aspergillus aculeatusYu-Qi Gao0Chun-Jun Guo1Qiang Zhang2Wen-Ming Zhou3Clay C. C. Wang4Jin-Ming Gao5Shaanxi Key Laboratory of Natural Products Chemical Biology, College of Science, Northwest A&F University, Yangling 712100, Shaanxi, ChinaDepartment of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USAShaanxi Key Laboratory of Natural Products Chemical Biology, College of Science, Northwest A&F University, Yangling 712100, Shaanxi, ChinaShaanxi Key Laboratory of Natural Products Chemical Biology, College of Science, Northwest A&F University, Yangling 712100, Shaanxi, ChinaDepartment of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USAShaanxi Key Laboratory of Natural Products Chemical Biology, College of Science, Northwest A&F University, Yangling 712100, Shaanxi, ChinaSix sesquiterpenoids 1–6, including two new ones, an ent-daucane-type sesquiterpenoid, asperaculane A (1), and a nordaucane one, asperaculane B (2), and four known nordaucane derivatives, aculenes A–D 3–6, together with the known secalonic acid D (7), were isolated from a fermentation culture of the fungus Aspergillus aculeatus. Their structures and absolute configurations were established by analyses of their spectroscopic data, including 1D and 2D-NMR spectra, HR-ESIMS, electronic circular dichroism (ECD) data, and quantum chemical calculations. These metabolites were evaluated for in vitro cytotoxic activity against two cell lines, human cancer cell lines (HeLa) and one normal hamster cell line (CHO).http://www.mdpi.com/1420-3049/20/1/325Aspergillus aculeatusnordaucane sesquiterpenoidsent-daucanesnatural productsstructure elucidation |
| spellingShingle | Yu-Qi Gao Chun-Jun Guo Qiang Zhang Wen-Ming Zhou Clay C. C. Wang Jin-Ming Gao Asperaculanes A and B, Two Sesquiterpenoids from the Fungus Aspergillus aculeatus Molecules Aspergillus aculeatus nordaucane sesquiterpenoids ent-daucanes natural products structure elucidation |
| title | Asperaculanes A and B, Two Sesquiterpenoids from the Fungus Aspergillus aculeatus |
| title_full | Asperaculanes A and B, Two Sesquiterpenoids from the Fungus Aspergillus aculeatus |
| title_fullStr | Asperaculanes A and B, Two Sesquiterpenoids from the Fungus Aspergillus aculeatus |
| title_full_unstemmed | Asperaculanes A and B, Two Sesquiterpenoids from the Fungus Aspergillus aculeatus |
| title_short | Asperaculanes A and B, Two Sesquiterpenoids from the Fungus Aspergillus aculeatus |
| title_sort | asperaculanes a and b two sesquiterpenoids from the fungus aspergillus aculeatus |
| topic | Aspergillus aculeatus nordaucane sesquiterpenoids ent-daucanes natural products structure elucidation |
| url | http://www.mdpi.com/1420-3049/20/1/325 |
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