YAP/TAZ initiate and maintain Schwann cell myelination
Nuclear exclusion of the transcriptional regulators and potent oncoproteins, YAP/TAZ, is considered necessary for adult tissue homeostasis. Here we show that nuclear YAP/TAZ are essential regulators of peripheral nerve development and myelin maintenance. To proliferate, developing Schwann cells (SCs...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2017-01-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/20982 |
| _version_ | 1811180383463538688 |
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| author | Matthew Grove Hyukmin Kim Maryline Santerre Alexander J Krupka Seung Baek Han Jinbin Zhai Jennifer Y Cho Raehee Park Michele Harris Seonhee Kim Bassel E Sawaya Shin H Kang Mary F Barbe Seo-Hee Cho Michel A Lemay Young-Jin Son |
| author_facet | Matthew Grove Hyukmin Kim Maryline Santerre Alexander J Krupka Seung Baek Han Jinbin Zhai Jennifer Y Cho Raehee Park Michele Harris Seonhee Kim Bassel E Sawaya Shin H Kang Mary F Barbe Seo-Hee Cho Michel A Lemay Young-Jin Son |
| author_sort | Matthew Grove |
| collection | DOAJ |
| description | Nuclear exclusion of the transcriptional regulators and potent oncoproteins, YAP/TAZ, is considered necessary for adult tissue homeostasis. Here we show that nuclear YAP/TAZ are essential regulators of peripheral nerve development and myelin maintenance. To proliferate, developing Schwann cells (SCs) require YAP/TAZ to enter S-phase and, without them, fail to generate sufficient SCs for timely axon sorting. To differentiate, SCs require YAP/TAZ to upregulate Krox20 and, without them, completely fail to myelinate, resulting in severe peripheral neuropathy. Remarkably, in adulthood, nuclear YAP/TAZ are selectively expressed by myelinating SCs, and conditional ablation results in severe peripheral demyelination and mouse death. YAP/TAZ regulate both developmental and adult myelination by driving TEAD1 to activate Krox20. Therefore, YAP/TAZ are crucial for SCs to myelinate developing nerve and to maintain myelinated nerve in adulthood. Our study also provides a new insight into the role of nuclear YAP/TAZ in homeostatic maintenance of an adult tissue. |
| first_indexed | 2024-04-11T09:02:16Z |
| format | Article |
| id | doaj.art-eae26989c1b34d3cb0582278302e9660 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:02:16Z |
| publishDate | 2017-01-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-eae26989c1b34d3cb0582278302e96602022-12-22T04:32:45ZengeLife Sciences Publications LtdeLife2050-084X2017-01-01610.7554/eLife.20982YAP/TAZ initiate and maintain Schwann cell myelinationMatthew Grove0Hyukmin Kim1Maryline Santerre2Alexander J Krupka3Seung Baek Han4Jinbin Zhai5Jennifer Y Cho6Raehee Park7Michele Harris8Seonhee Kim9Bassel E Sawaya10Shin H Kang11Mary F Barbe12Seo-Hee Cho13Michel A Lemay14Young-Jin Son15https://orcid.org/0000-0001-5725-9775Shriners Hospitals Pediatric Research Center, Center for Neural Repair, Lewis Katz School of Medicine, Temple University, Philadelphia, United States; Department of Anatomy and Cell Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, United StatesShriners Hospitals Pediatric Research Center, Center for Neural Repair, Lewis Katz School of Medicine, Temple University, Philadelphia, United States; Department of Anatomy and Cell Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, United StatesFELS Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, United StatesDepartment of Bioengineering, Temple University, Philadelphia, United StatesShriners Hospitals Pediatric Research Center, Center for Neural Repair, Lewis Katz School of Medicine, Temple University, Philadelphia, United States; Department of Anatomy and Cell Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, United StatesShriners Hospitals Pediatric Research Center, Center for Neural Repair, Lewis Katz School of Medicine, Temple University, Philadelphia, United States; Department of Anatomy and Cell Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, United StatesShriners Hospitals Pediatric Research Center, Center for Neural Repair, Lewis Katz School of Medicine, Temple University, Philadelphia, United StatesShriners Hospitals Pediatric Research Center, Center for Neural Repair, Lewis Katz School of Medicine, Temple University, Philadelphia, United States; Department of Anatomy and Cell Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, United StatesDepartment of Anatomy and Cell Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, United StatesShriners Hospitals Pediatric Research Center, Center for Neural Repair, Lewis Katz School of Medicine, Temple University, Philadelphia, United States; Department of Anatomy and Cell Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, United StatesFELS Institute for Cancer Research and Molecular Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, United StatesShriners Hospitals Pediatric Research Center, Center for Neural Repair, Lewis Katz School of Medicine, Temple University, Philadelphia, United States; Department of Anatomy and Cell Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, United StatesDepartment of Anatomy and Cell Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, United StatesShriners Hospitals Pediatric Research Center, Center for Neural Repair, Lewis Katz School of Medicine, Temple University, Philadelphia, United States; Department of Anatomy and Cell Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, United StatesDepartment of Bioengineering, Temple University, Philadelphia, United StatesShriners Hospitals Pediatric Research Center, Center for Neural Repair, Lewis Katz School of Medicine, Temple University, Philadelphia, United States; Department of Anatomy and Cell Biology, Lewis Katz School of Medicine, Temple University, Philadelphia, United StatesNuclear exclusion of the transcriptional regulators and potent oncoproteins, YAP/TAZ, is considered necessary for adult tissue homeostasis. Here we show that nuclear YAP/TAZ are essential regulators of peripheral nerve development and myelin maintenance. To proliferate, developing Schwann cells (SCs) require YAP/TAZ to enter S-phase and, without them, fail to generate sufficient SCs for timely axon sorting. To differentiate, SCs require YAP/TAZ to upregulate Krox20 and, without them, completely fail to myelinate, resulting in severe peripheral neuropathy. Remarkably, in adulthood, nuclear YAP/TAZ are selectively expressed by myelinating SCs, and conditional ablation results in severe peripheral demyelination and mouse death. YAP/TAZ regulate both developmental and adult myelination by driving TEAD1 to activate Krox20. Therefore, YAP/TAZ are crucial for SCs to myelinate developing nerve and to maintain myelinated nerve in adulthood. Our study also provides a new insight into the role of nuclear YAP/TAZ in homeostatic maintenance of an adult tissue.https://elifesciences.org/articles/20982Egr2TEADTazdemyelinationSchwann cells |
| spellingShingle | Matthew Grove Hyukmin Kim Maryline Santerre Alexander J Krupka Seung Baek Han Jinbin Zhai Jennifer Y Cho Raehee Park Michele Harris Seonhee Kim Bassel E Sawaya Shin H Kang Mary F Barbe Seo-Hee Cho Michel A Lemay Young-Jin Son YAP/TAZ initiate and maintain Schwann cell myelination eLife Egr2 TEAD Taz demyelination Schwann cells |
| title | YAP/TAZ initiate and maintain Schwann cell myelination |
| title_full | YAP/TAZ initiate and maintain Schwann cell myelination |
| title_fullStr | YAP/TAZ initiate and maintain Schwann cell myelination |
| title_full_unstemmed | YAP/TAZ initiate and maintain Schwann cell myelination |
| title_short | YAP/TAZ initiate and maintain Schwann cell myelination |
| title_sort | yap taz initiate and maintain schwann cell myelination |
| topic | Egr2 TEAD Taz demyelination Schwann cells |
| url | https://elifesciences.org/articles/20982 |
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