Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies
Abstract The injured spinal cord is difficult to repair and regenerate. Traditional treatments are not effective. Stem cells are a type of cells that have the potential to differentiate into various cells, including neurons. They exert a therapeutic effect by safely and effectively differentiating i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-08-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13287-019-1357-z |
| _version_ | 1818292819426541568 |
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| author | Anwen Shao Sheng Tu Jianan Lu Jianmin Zhang |
| author_facet | Anwen Shao Sheng Tu Jianan Lu Jianmin Zhang |
| author_sort | Anwen Shao |
| collection | DOAJ |
| description | Abstract The injured spinal cord is difficult to repair and regenerate. Traditional treatments are not effective. Stem cells are a type of cells that have the potential to differentiate into various cells, including neurons. They exert a therapeutic effect by safely and effectively differentiating into neurons or replacing damaged cells, secreting neurotrophic factors, and inhibiting the inflammatory response. Many types of stem cells have been used for transplantation, and each has its own advantages and disadvantages. This review discusses the possible mechanisms of stem cell therapy for spinal cord injury, and the types of stem cells commonly used in experiments, to provide a reference for basic and clinical research on stem cell therapy for spinal cord injury. |
| first_indexed | 2024-12-13T03:06:01Z |
| format | Article |
| id | doaj.art-eae323d6bd1b43e093d33a8e04c7b353 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-12-13T03:06:01Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-eae323d6bd1b43e093d33a8e04c7b3532022-12-22T00:01:44ZengBMCStem Cell Research & Therapy1757-65122019-08-0110111310.1186/s13287-019-1357-zCrosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategiesAnwen Shao0Sheng Tu1Jianan Lu2Jianmin Zhang3Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang UniversityDepartment of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang UniversityAbstract The injured spinal cord is difficult to repair and regenerate. Traditional treatments are not effective. Stem cells are a type of cells that have the potential to differentiate into various cells, including neurons. They exert a therapeutic effect by safely and effectively differentiating into neurons or replacing damaged cells, secreting neurotrophic factors, and inhibiting the inflammatory response. Many types of stem cells have been used for transplantation, and each has its own advantages and disadvantages. This review discusses the possible mechanisms of stem cell therapy for spinal cord injury, and the types of stem cells commonly used in experiments, to provide a reference for basic and clinical research on stem cell therapy for spinal cord injury.http://link.springer.com/article/10.1186/s13287-019-1357-zSpinal cord injuryStem cellMechanismTherapyReview |
| spellingShingle | Anwen Shao Sheng Tu Jianan Lu Jianmin Zhang Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies Stem Cell Research & Therapy Spinal cord injury Stem cell Mechanism Therapy Review |
| title | Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies |
| title_full | Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies |
| title_fullStr | Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies |
| title_full_unstemmed | Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies |
| title_short | Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies |
| title_sort | crosstalk between stem cell and spinal cord injury pathophysiology and treatment strategies |
| topic | Spinal cord injury Stem cell Mechanism Therapy Review |
| url | http://link.springer.com/article/10.1186/s13287-019-1357-z |
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