The role of tissue factor in normal pregnancy and in the development of preeclampsia: A review
Background: Tissue factor (TF) is a key element for normal gestation, especially in the first trimester. TF levels are hence raised in pregnancy, producing an adaptive hypercoagulable state. Potentiated hypercoagulability however, is associated with disorders of pregnancy such as pre-eclampsia but t...
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| Format: | Article |
| Language: | English |
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Palacký University Olomouc, Faculty of Medicine and Dentistry
2015-06-01
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| Series: | Biomedical Papers |
| Subjects: | |
| Online Access: | https://biomed.papers.upol.cz/artkey/bio-201502-0004_The_role_of_tissue_factor_in_normal_pregnancy_and_in_the_development_of_preeclampsia_A_review.php |
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| author | Jana Prochazkova Ludek Slavik Jana Ulehlova Martin Prochazka |
| author_facet | Jana Prochazkova Ludek Slavik Jana Ulehlova Martin Prochazka |
| author_sort | Jana Prochazkova |
| collection | DOAJ |
| description | Background: Tissue factor (TF) is a key element for normal gestation, especially in the first trimester. TF levels are hence raised in pregnancy, producing an adaptive hypercoagulable state. Potentiated hypercoagulability however, is associated with disorders of pregnancy such as pre-eclampsia but the results of TF and its inhibitor, tissue factor pathway inhibitor (TFPI), measurement, in pre eclampsic women are ambiguous and the data conflicting. This review covers the current knowledge status of the role of TF assessment in pregnancy with a focus on its diagnostic utility.
Methods: A review of the literature using the following key words: tissue factor, thrombosis, inflammation, pregnancy, preeclampsia.
Results: The published literature shows raised and unchanged TF levels in various studies of pre-eclampsia along with equally conflicting data for TFPI. The various study designs and methods used in these studies makes valid comparison difficult. Meta analysis of 34 randomized trials showed that low-dose aspirin in early phases of gravidity (starting from the 16th week or earlier) significantly reduces the incidence of preeclampsia.
Conclusions: Overall, the results of the literature search together with knowledge of the structure and biological effects of TF, suggest that measuring the level of plasma TF/TFPI is not ideal for determining the actual levels of TF in the uteroplacental circulation. The current view that endothelial dysfunction is the trigger for preeclampsia, suggests that aspirin may be an effective prophylaxis. Further research will be necessary: measuring the expression of tissue factor on monocytes using flowcytometry and comparing the development of this expression during normal pregnancy and pregnancy complicated by preeclampsia, for example. Another possibility is immunohistochemical determination of the level of TF expression directly in placental tissue. |
| first_indexed | 2024-12-10T17:25:55Z |
| format | Article |
| id | doaj.art-eae36192d764460cba6724eba95490d1 |
| institution | Directory Open Access Journal |
| issn | 1213-8118 1804-7521 |
| language | English |
| last_indexed | 2024-12-10T17:25:55Z |
| publishDate | 2015-06-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj.art-eae36192d764460cba6724eba95490d12022-12-22T01:39:51ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212015-06-01159219219610.5507/bp.2014.061bio-201502-0004The role of tissue factor in normal pregnancy and in the development of preeclampsia: A reviewJana Prochazkova0Ludek Slavik1Jana Ulehlova2Martin Prochazka3Department of Hemato-oncology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech RepublicDepartment of Hemato-oncology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech RepublicDepartment of Hemato-oncology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech RepublicDepartment of Obstetrics and Gynecology, University Hospital Olomouc and Faculty of Medicine and Dentistry, Palacky University OlomoucBackground: Tissue factor (TF) is a key element for normal gestation, especially in the first trimester. TF levels are hence raised in pregnancy, producing an adaptive hypercoagulable state. Potentiated hypercoagulability however, is associated with disorders of pregnancy such as pre-eclampsia but the results of TF and its inhibitor, tissue factor pathway inhibitor (TFPI), measurement, in pre eclampsic women are ambiguous and the data conflicting. This review covers the current knowledge status of the role of TF assessment in pregnancy with a focus on its diagnostic utility. Methods: A review of the literature using the following key words: tissue factor, thrombosis, inflammation, pregnancy, preeclampsia. Results: The published literature shows raised and unchanged TF levels in various studies of pre-eclampsia along with equally conflicting data for TFPI. The various study designs and methods used in these studies makes valid comparison difficult. Meta analysis of 34 randomized trials showed that low-dose aspirin in early phases of gravidity (starting from the 16th week or earlier) significantly reduces the incidence of preeclampsia. Conclusions: Overall, the results of the literature search together with knowledge of the structure and biological effects of TF, suggest that measuring the level of plasma TF/TFPI is not ideal for determining the actual levels of TF in the uteroplacental circulation. The current view that endothelial dysfunction is the trigger for preeclampsia, suggests that aspirin may be an effective prophylaxis. Further research will be necessary: measuring the expression of tissue factor on monocytes using flowcytometry and comparing the development of this expression during normal pregnancy and pregnancy complicated by preeclampsia, for example. Another possibility is immunohistochemical determination of the level of TF expression directly in placental tissue.https://biomed.papers.upol.cz/artkey/bio-201502-0004_The_role_of_tissue_factor_in_normal_pregnancy_and_in_the_development_of_preeclampsia_A_review.phptissue factorthrombosisinflammationpregnancypreeclampsia |
| spellingShingle | Jana Prochazkova Ludek Slavik Jana Ulehlova Martin Prochazka The role of tissue factor in normal pregnancy and in the development of preeclampsia: A review Biomedical Papers tissue factor thrombosis inflammation pregnancy preeclampsia |
| title | The role of tissue factor in normal pregnancy and in the development of preeclampsia: A review |
| title_full | The role of tissue factor in normal pregnancy and in the development of preeclampsia: A review |
| title_fullStr | The role of tissue factor in normal pregnancy and in the development of preeclampsia: A review |
| title_full_unstemmed | The role of tissue factor in normal pregnancy and in the development of preeclampsia: A review |
| title_short | The role of tissue factor in normal pregnancy and in the development of preeclampsia: A review |
| title_sort | role of tissue factor in normal pregnancy and in the development of preeclampsia a review |
| topic | tissue factor thrombosis inflammation pregnancy preeclampsia |
| url | https://biomed.papers.upol.cz/artkey/bio-201502-0004_The_role_of_tissue_factor_in_normal_pregnancy_and_in_the_development_of_preeclampsia_A_review.php |
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