The roles of microtubule-based transport at presynaptic nerve terminals
Targeted intracellular movement of presynaptic proteins plays important roles during synapse formation and, later, in the homeostatic maintenance of mature synapses. Movement of these proteins is mediated by motor complexes travelling along intracellular cytoskeletal networks often in the form of ve...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-02-01
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| Series: | Frontiers in Synaptic Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnsyn.2016.00003/full |
| _version_ | 1811214624256688128 |
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| author | Oleksandr eYagensky Tahere eKalantary Dehaghi John Jia En eChua John Jia En eChua John Jia En eChua |
| author_facet | Oleksandr eYagensky Tahere eKalantary Dehaghi John Jia En eChua John Jia En eChua John Jia En eChua |
| author_sort | Oleksandr eYagensky |
| collection | DOAJ |
| description | Targeted intracellular movement of presynaptic proteins plays important roles during synapse formation and, later, in the homeostatic maintenance of mature synapses. Movement of these proteins is mediated by motor complexes travelling along intracellular cytoskeletal networks often in the form of vesicular packages. Presynaptic protein transport by kinesin motors in particular plays important roles during synaptogenesis to bring newly synthesized proteins to establish nascent synaptic sites. Conversely, movement of proteins away from presynaptic sites by dynein motors enables synapse-nuclear signaling and allows for synaptic renewal through degradation of unwanted or damaged proteins. Remarkably, recent data has indicated that synaptic and protein trafficking machineries can modulate each other’s functions. Here, we survey the mechanisms involved in moving presynaptic components to and away from synapses and how this process supports presynaptic function. |
| first_indexed | 2024-04-12T06:07:48Z |
| format | Article |
| id | doaj.art-eae3d452930145d2be07219700bd9359 |
| institution | Directory Open Access Journal |
| issn | 1663-3563 |
| language | English |
| last_indexed | 2024-04-12T06:07:48Z |
| publishDate | 2016-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Synaptic Neuroscience |
| spelling | doaj.art-eae3d452930145d2be07219700bd93592022-12-22T03:44:49ZengFrontiers Media S.A.Frontiers in Synaptic Neuroscience1663-35632016-02-01810.3389/fnsyn.2016.00003175980The roles of microtubule-based transport at presynaptic nerve terminalsOleksandr eYagensky0Tahere eKalantary Dehaghi1John Jia En eChua2John Jia En eChua3John Jia En eChua4Max Planck Institute For Biophysical ChemistryMax Planck Institute For Biophysical ChemistryNational University of SingaporeNational University of SingaporeMax Planck Institute For Biophysical ChemistryTargeted intracellular movement of presynaptic proteins plays important roles during synapse formation and, later, in the homeostatic maintenance of mature synapses. Movement of these proteins is mediated by motor complexes travelling along intracellular cytoskeletal networks often in the form of vesicular packages. Presynaptic protein transport by kinesin motors in particular plays important roles during synaptogenesis to bring newly synthesized proteins to establish nascent synaptic sites. Conversely, movement of proteins away from presynaptic sites by dynein motors enables synapse-nuclear signaling and allows for synaptic renewal through degradation of unwanted or damaged proteins. Remarkably, recent data has indicated that synaptic and protein trafficking machineries can modulate each other’s functions. Here, we survey the mechanisms involved in moving presynaptic components to and away from synapses and how this process supports presynaptic function.http://journal.frontiersin.org/Journal/10.3389/fnsyn.2016.00003/fullAutophagyDyneinsKinesinintracellular traffickingSignaling Pathwayssynaptogenesis |
| spellingShingle | Oleksandr eYagensky Tahere eKalantary Dehaghi John Jia En eChua John Jia En eChua John Jia En eChua The roles of microtubule-based transport at presynaptic nerve terminals Frontiers in Synaptic Neuroscience Autophagy Dyneins Kinesin intracellular trafficking Signaling Pathways synaptogenesis |
| title | The roles of microtubule-based transport at presynaptic nerve terminals |
| title_full | The roles of microtubule-based transport at presynaptic nerve terminals |
| title_fullStr | The roles of microtubule-based transport at presynaptic nerve terminals |
| title_full_unstemmed | The roles of microtubule-based transport at presynaptic nerve terminals |
| title_short | The roles of microtubule-based transport at presynaptic nerve terminals |
| title_sort | roles of microtubule based transport at presynaptic nerve terminals |
| topic | Autophagy Dyneins Kinesin intracellular trafficking Signaling Pathways synaptogenesis |
| url | http://journal.frontiersin.org/Journal/10.3389/fnsyn.2016.00003/full |
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