Malignancy in ankylosing spondylitis: a cross-sectional analysis of a large population database
Abstract Background Increased cancer-risk has been reported with rheumatoid arthritis and systemic lupus erythematosus, but the risk is poorly studied in ankylosing spondylitis (AS). Conflicting data in AS have been reported in Asia and Europe, with lack of US population-based studies. Our objective...
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | BMC Rheumatology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41927-022-00275-x |
| _version_ | 1817976517673615360 |
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| author | Mohamad Bittar Sali Merjanah Reem Alkilany Marina Magrey |
| author_facet | Mohamad Bittar Sali Merjanah Reem Alkilany Marina Magrey |
| author_sort | Mohamad Bittar |
| collection | DOAJ |
| description | Abstract Background Increased cancer-risk has been reported with rheumatoid arthritis and systemic lupus erythematosus, but the risk is poorly studied in ankylosing spondylitis (AS). Conflicting data in AS have been reported in Asia and Europe, with lack of US population-based studies. Our objective is to study the prevalence of cancer in patients with AS in the US. Methods Using the Explorys database, we performed a cross-sectional study. Data from AS patients and controls were stratified by 2 rheumatology visits, age groups, clinical characteristics, and frequency of cancers. The data were analyzed using a series of chi-square tests of independence as well as logistic regression to test for association between AS and cancer. Results 1410 AS patients (12.88%) had cancer. Female AS patients had a lower prevalence of cancer compared to controls (OR 0.840, 95% CI [0.769, 0.916]), while male AS patients had no statistically significant difference (OR 1.011, 95% CI [0.929, 1.099]). Among patients with AS, Skin cancers (squamous cell, malignant melanoma, and basal cell) and head and neck cancers were significantly increased. Conclusion Our study demonstrated that the prevalence of “any-type-cancer” was not increased in AS patients compared to controls with no rheumatic disease. Skin, head, and neck cancers were more frequently seen in AS patients. |
| first_indexed | 2024-04-13T22:04:38Z |
| format | Article |
| id | doaj.art-eae3dd62d8834b89a981dd4aa2e698c2 |
| institution | Directory Open Access Journal |
| issn | 2520-1026 |
| language | English |
| last_indexed | 2024-04-13T22:04:38Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Rheumatology |
| spelling | doaj.art-eae3dd62d8834b89a981dd4aa2e698c22022-12-22T02:27:59ZengBMCBMC Rheumatology2520-10262022-06-01611610.1186/s41927-022-00275-xMalignancy in ankylosing spondylitis: a cross-sectional analysis of a large population databaseMohamad Bittar0Sali Merjanah1Reem Alkilany2Marina Magrey3Division of Connective Tissue Disease (Rheumatology), The University of Tennessee Health Science CenterDivision of Rheumatology, Boston UniversityDepartment of Medicine, The MetroHealth System Campus of Case Western Reserve UniversityDivision of Rheumatology, University Hospitals/Case Western Reserve UniversityAbstract Background Increased cancer-risk has been reported with rheumatoid arthritis and systemic lupus erythematosus, but the risk is poorly studied in ankylosing spondylitis (AS). Conflicting data in AS have been reported in Asia and Europe, with lack of US population-based studies. Our objective is to study the prevalence of cancer in patients with AS in the US. Methods Using the Explorys database, we performed a cross-sectional study. Data from AS patients and controls were stratified by 2 rheumatology visits, age groups, clinical characteristics, and frequency of cancers. The data were analyzed using a series of chi-square tests of independence as well as logistic regression to test for association between AS and cancer. Results 1410 AS patients (12.88%) had cancer. Female AS patients had a lower prevalence of cancer compared to controls (OR 0.840, 95% CI [0.769, 0.916]), while male AS patients had no statistically significant difference (OR 1.011, 95% CI [0.929, 1.099]). Among patients with AS, Skin cancers (squamous cell, malignant melanoma, and basal cell) and head and neck cancers were significantly increased. Conclusion Our study demonstrated that the prevalence of “any-type-cancer” was not increased in AS patients compared to controls with no rheumatic disease. Skin, head, and neck cancers were more frequently seen in AS patients.https://doi.org/10.1186/s41927-022-00275-xAnkylosing spondylitisAxial spondyloarthritisMalignancyCancerEpidemiology |
| spellingShingle | Mohamad Bittar Sali Merjanah Reem Alkilany Marina Magrey Malignancy in ankylosing spondylitis: a cross-sectional analysis of a large population database BMC Rheumatology Ankylosing spondylitis Axial spondyloarthritis Malignancy Cancer Epidemiology |
| title | Malignancy in ankylosing spondylitis: a cross-sectional analysis of a large population database |
| title_full | Malignancy in ankylosing spondylitis: a cross-sectional analysis of a large population database |
| title_fullStr | Malignancy in ankylosing spondylitis: a cross-sectional analysis of a large population database |
| title_full_unstemmed | Malignancy in ankylosing spondylitis: a cross-sectional analysis of a large population database |
| title_short | Malignancy in ankylosing spondylitis: a cross-sectional analysis of a large population database |
| title_sort | malignancy in ankylosing spondylitis a cross sectional analysis of a large population database |
| topic | Ankylosing spondylitis Axial spondyloarthritis Malignancy Cancer Epidemiology |
| url | https://doi.org/10.1186/s41927-022-00275-x |
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