Efficacy and Safety of Ejiao (Asini Corii Colla) in Women With Blood Deficient Symptoms: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial
Equus asinus L [Equidae; Asini Corii Colla] (donkey-hide gelatin, Ejiao), a well-known traditional Chinese medicine, has been widely used to nourish the blood, especially for women. The aim of this study was to assess the efficacy and safety of Ejiao in blood-deficient patients. A total of 210 parti...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.718154/full |
| _version_ | 1831770849313554432 |
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| author | Li Zhang Li Zhang Zhongju Xu Tao Jiang Jialu Zhang Pinxian Huang Jiaqi Tan Gan Chen Man Yuan Zhuo Li Haibin Liu Dengfeng Gao Lianbo Xiao Hui Feng Jiatuo Xu Hongxi Xu Hongxi Xu |
| author_facet | Li Zhang Li Zhang Zhongju Xu Tao Jiang Jialu Zhang Pinxian Huang Jiaqi Tan Gan Chen Man Yuan Zhuo Li Haibin Liu Dengfeng Gao Lianbo Xiao Hui Feng Jiatuo Xu Hongxi Xu Hongxi Xu |
| author_sort | Li Zhang |
| collection | DOAJ |
| description | Equus asinus L [Equidae; Asini Corii Colla] (donkey-hide gelatin, Ejiao), a well-known traditional Chinese medicine, has been widely used to nourish the blood, especially for women. The aim of this study was to assess the efficacy and safety of Ejiao in blood-deficient patients. A total of 210 participants were recruited and randomly allocated into the placebo control group and Ejiao-treated group (6 g/day). The primary outcomes on the efficacy of Ejiao included traditional Chinese medicine symptom scores, blood indicators, and SF-36. The secondary outcomes were changes in fireness and safety evaluation. Results showed that Ejiao treatment for 8 weeks had significantly improved dizziness symptoms. Among the tested 24 blood biochemical parameters, the hematocrit and red blood cell numbers decreased in the placebo control group, but decreased significantly less in the Ejiao treatment group. The white blood cell and neutrophil counts increased in the Ejiao group but were within the normal range. In addition, the quality of life improved as the scores in SF-36 domains were significantly higher in the Ejiao group. At the same time, there was no significant change in the fire–heat symptoms score or other safety parameters. Considering all these, our study showed that Ejiao has a promising effect in women suffering from blood deficiency without obvious adverse effects. |
| first_indexed | 2024-12-22T07:47:49Z |
| format | Article |
| id | doaj.art-eae64a0a64e34cdda8693f875ba7f989 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-22T07:47:49Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-eae64a0a64e34cdda8693f875ba7f9892022-12-21T18:33:35ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-10-011210.3389/fphar.2021.718154718154Efficacy and Safety of Ejiao (Asini Corii Colla) in Women With Blood Deficient Symptoms: A Randomized, Double-Blind, and Placebo-Controlled Clinical TrialLi Zhang0Li Zhang1Zhongju Xu2Tao Jiang3Jialu Zhang4Pinxian Huang5Jiaqi Tan6Gan Chen7Man Yuan8Zhuo Li9Haibin Liu10Dengfeng Gao11Lianbo Xiao12Hui Feng13Jiatuo Xu14Hongxi Xu15Hongxi Xu16Institute of Arthritis Research, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Arthritis Research, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaNational Engineering Research Center for Gelatin-based Traditional Chinese Medicine, Dong-E-E-Jiao Co. Ltd., Done-E Country, ChinaNational Engineering Research Center for Gelatin-based Traditional Chinese Medicine, Dong-E-E-Jiao Co. Ltd., Done-E Country, ChinaInstitute of Arthritis Research, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Arthritis Research, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaInstitute of Arthritis Research, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaEquus asinus L [Equidae; Asini Corii Colla] (donkey-hide gelatin, Ejiao), a well-known traditional Chinese medicine, has been widely used to nourish the blood, especially for women. The aim of this study was to assess the efficacy and safety of Ejiao in blood-deficient patients. A total of 210 participants were recruited and randomly allocated into the placebo control group and Ejiao-treated group (6 g/day). The primary outcomes on the efficacy of Ejiao included traditional Chinese medicine symptom scores, blood indicators, and SF-36. The secondary outcomes were changes in fireness and safety evaluation. Results showed that Ejiao treatment for 8 weeks had significantly improved dizziness symptoms. Among the tested 24 blood biochemical parameters, the hematocrit and red blood cell numbers decreased in the placebo control group, but decreased significantly less in the Ejiao treatment group. The white blood cell and neutrophil counts increased in the Ejiao group but were within the normal range. In addition, the quality of life improved as the scores in SF-36 domains were significantly higher in the Ejiao group. At the same time, there was no significant change in the fire–heat symptoms score or other safety parameters. Considering all these, our study showed that Ejiao has a promising effect in women suffering from blood deficiency without obvious adverse effects.https://www.frontiersin.org/articles/10.3389/fphar.2021.718154/fullasini corii colla (Ejiao)blood deficient symptomsrandomized controlled trialanemiaTCM syndromes |
| spellingShingle | Li Zhang Li Zhang Zhongju Xu Tao Jiang Jialu Zhang Pinxian Huang Jiaqi Tan Gan Chen Man Yuan Zhuo Li Haibin Liu Dengfeng Gao Lianbo Xiao Hui Feng Jiatuo Xu Hongxi Xu Hongxi Xu Efficacy and Safety of Ejiao (Asini Corii Colla) in Women With Blood Deficient Symptoms: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial Frontiers in Pharmacology asini corii colla (Ejiao) blood deficient symptoms randomized controlled trial anemia TCM syndromes |
| title | Efficacy and Safety of Ejiao (Asini Corii Colla) in Women With Blood Deficient Symptoms: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial |
| title_full | Efficacy and Safety of Ejiao (Asini Corii Colla) in Women With Blood Deficient Symptoms: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial |
| title_fullStr | Efficacy and Safety of Ejiao (Asini Corii Colla) in Women With Blood Deficient Symptoms: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial |
| title_full_unstemmed | Efficacy and Safety of Ejiao (Asini Corii Colla) in Women With Blood Deficient Symptoms: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial |
| title_short | Efficacy and Safety of Ejiao (Asini Corii Colla) in Women With Blood Deficient Symptoms: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial |
| title_sort | efficacy and safety of ejiao asini corii colla in women with blood deficient symptoms a randomized double blind and placebo controlled clinical trial |
| topic | asini corii colla (Ejiao) blood deficient symptoms randomized controlled trial anemia TCM syndromes |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.718154/full |
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