Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency

Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency

Abstract Arginase-1 deficiency in humans is a rare genetic disorder of metabolism resulting from a loss of arginase-1, leading to impaired ureagenesis, hyperargininemia and neurological deficits. Previously, we generated a tamoxifen-inducible arginase-1 deficient mouse model harboring a deletion of...

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Bibliographic Details
Main Authors:	Yuan Yan Sin, Phillipe R. Price, Laurel L. Ballantyne, Colin D. Funk
Format:	Article
Language:	English
Published:	Nature Portfolio 2017-05-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-017-02927-2

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