The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma

The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma

Abstract Background Synthetic indolyl- pyridinyl- propenones (IPPs) induce methuosis, a form of non-apoptotic cell death, in glioblastoma and other cancer cell lines. Methuosis is characterized by accumulation of cytoplasmic vacuoles derived from macropinosomes and late endosomes, followed by metabo...

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Bibliographic Details
Main Authors: Zehui Li, Nneka E. Mbah, Jean H. Overmeyer, Jeffrey G. Sarver, Sage George, Christopher J. Trabbic, Paul W. Erhardt, William A. Maltese
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Cancer
Subjects:
Glioblastoma
Methuosis
Cell death
Chalcones
C-Jun N-terminal kinase
Vacuoles
Online Access:http://link.springer.com/article/10.1186/s12885-019-5288-y

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http://link.springer.com/article/10.1186/s12885-019-5288-y

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