Funciones termodinámicas relativas a la transferencia del ketoprófen desde el agua hasta algunos sistemas orgánicos Thermodynamic functions relative to the transfer of ketoprofen from water to some organic systems
<abstract language="eng">The thermodynamics of molal partitioning of ketoprofen (KTP) was studied in cyclohexane/buffer (CH/W), octanol/buffer (ROH/W), and dimyristoyl phosphatidylcholine (DMPC), dipalmitoyl phosphatidylcholine (DPPC), and egg lecithin (EGG/W) liposome systems. In al...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2006-07-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000400015 |
| _version_ | 1819066314793156608 |
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| author | Hernán R. Lozano Fleming Martínez |
| author_facet | Hernán R. Lozano Fleming Martínez |
| author_sort | Hernán R. Lozano |
| collection | DOAJ |
| description | <abstract language="eng">The thermodynamics of molal partitioning of ketoprofen (KTP) was studied in cyclohexane/buffer (CH/W), octanol/buffer (ROH/W), and dimyristoyl phosphatidylcholine (DMPC), dipalmitoyl phosphatidylcholine (DPPC), and egg lecithin (EGG/W) liposome systems. In all cases the partition coefficients (Kmo/w)were greater than unity; therefore the standard free energies of transfer were negative indicating affinity of KTP for organic media. The Kmo/w values were approximately seventy-fold higher in the ROH/W system compared with the CH/W system. On the other hand, the Kmo/w values were approximately ten or fifty-fold higher in the liposomes compared with the ROH/W system. In all cases, the standard enthalpies and entropies of transfer of KTP were positive indicating some degree of participation of the hydrophobic hydration on partitioning processes. |
| first_indexed | 2024-12-21T16:00:24Z |
| format | Article |
| id | doaj.art-eae79a86414641f3bf7472a1936d0086 |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-12-21T16:00:24Z |
| publishDate | 2006-07-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-eae79a86414641f3bf7472a1936d00862022-12-21T18:58:00ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642006-07-0129470470910.1590/S0100-40422006000400015Funciones termodinámicas relativas a la transferencia del ketoprófen desde el agua hasta algunos sistemas orgánicos Thermodynamic functions relative to the transfer of ketoprofen from water to some organic systemsHernán R. LozanoFleming Martínez<abstract language="eng">The thermodynamics of molal partitioning of ketoprofen (KTP) was studied in cyclohexane/buffer (CH/W), octanol/buffer (ROH/W), and dimyristoyl phosphatidylcholine (DMPC), dipalmitoyl phosphatidylcholine (DPPC), and egg lecithin (EGG/W) liposome systems. In all cases the partition coefficients (Kmo/w)were greater than unity; therefore the standard free energies of transfer were negative indicating affinity of KTP for organic media. The Kmo/w values were approximately seventy-fold higher in the ROH/W system compared with the CH/W system. On the other hand, the Kmo/w values were approximately ten or fifty-fold higher in the liposomes compared with the ROH/W system. In all cases, the standard enthalpies and entropies of transfer of KTP were positive indicating some degree of participation of the hydrophobic hydration on partitioning processes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000400015ketoprofenpartition coefficientliposomes |
| spellingShingle | Hernán R. Lozano Fleming Martínez Funciones termodinámicas relativas a la transferencia del ketoprófen desde el agua hasta algunos sistemas orgánicos Thermodynamic functions relative to the transfer of ketoprofen from water to some organic systems Química Nova ketoprofen partition coefficient liposomes |
| title | Funciones termodinámicas relativas a la transferencia del ketoprófen desde el agua hasta algunos sistemas orgánicos Thermodynamic functions relative to the transfer of ketoprofen from water to some organic systems |
| title_full | Funciones termodinámicas relativas a la transferencia del ketoprófen desde el agua hasta algunos sistemas orgánicos Thermodynamic functions relative to the transfer of ketoprofen from water to some organic systems |
| title_fullStr | Funciones termodinámicas relativas a la transferencia del ketoprófen desde el agua hasta algunos sistemas orgánicos Thermodynamic functions relative to the transfer of ketoprofen from water to some organic systems |
| title_full_unstemmed | Funciones termodinámicas relativas a la transferencia del ketoprófen desde el agua hasta algunos sistemas orgánicos Thermodynamic functions relative to the transfer of ketoprofen from water to some organic systems |
| title_short | Funciones termodinámicas relativas a la transferencia del ketoprófen desde el agua hasta algunos sistemas orgánicos Thermodynamic functions relative to the transfer of ketoprofen from water to some organic systems |
| title_sort | funciones termodinamicas relativas a la transferencia del ketoprofen desde el agua hasta algunos sistemas organicos thermodynamic functions relative to the transfer of ketoprofen from water to some organic systems |
| topic | ketoprofen partition coefficient liposomes |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000400015 |
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