Bradyarrhythmias in Cardio-Oncology
The relationship between bradyarrhythmias and cancer therapies has not been well described but is increasingly recognized. There have been extensive advances in oncological pharmacotherapy, with several new classes of drugs available including targeted agents, immune checkpoint inhibitors and CAR T...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2021-09-01
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| Series: | South Asian Journal of Cancer |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1731907 |
| _version_ | 1819103512067309568 |
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| author | Marta Fonseca Evaline Cheng Duc Do Shouvik Haldar Shelby Kutty Eric H. Yang Arjun K. Ghosh Avirup Guha |
| author_facet | Marta Fonseca Evaline Cheng Duc Do Shouvik Haldar Shelby Kutty Eric H. Yang Arjun K. Ghosh Avirup Guha |
| author_sort | Marta Fonseca |
| collection | DOAJ |
| description | The relationship between bradyarrhythmias and cancer therapies has not been well described but is increasingly recognized. There have been extensive advances in oncological pharmacotherapy, with several new classes of drugs available including targeted agents, immune checkpoint inhibitors and CAR T cell therapy. This increasing repertoire of available drugs has revolutionized overall prognosis and survival of cancer patients but the true extent of their cardiovascular toxicity is only beginning to be understood. Previous studies and published reviews have traditionally focused on conventional chemotherapies and in arrhythmias in general, particularly tachyarrhythmias. The number of patients with both cancer and cardiovascular problems is increasing globally and oncologists and cardiologists need to be adept at managing arrythmia based scenarios. Greater collaboration between the two specialties including studies with prospective data collection in Cardio-Oncology are much needed to fill in knowledge gaps in this arena. This case-based review summarizes current available evidence of cancer treatment-related bradyarrhythmia incidence (including its different subtypes), possible mechanisms and outcomes. Furthermore, we propose a stepwise surveillance and management protocol for patients with suspected bradyarrhythmia related to cancer treatment. |
| first_indexed | 2024-12-22T01:51:38Z |
| format | Article |
| id | doaj.art-eae8c646f407421fac652ec1e244e47d |
| institution | Directory Open Access Journal |
| issn | 2278-330X 2278-4306 |
| language | English |
| last_indexed | 2024-12-22T01:51:38Z |
| publishDate | 2021-09-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | South Asian Journal of Cancer |
| spelling | doaj.art-eae8c646f407421fac652ec1e244e47d2022-12-21T18:42:55ZengThieme Medical and Scientific Publishers Pvt. Ltd.South Asian Journal of Cancer2278-330X2278-43062021-09-01100319521010.1055/s-0041-1731907Bradyarrhythmias in Cardio-OncologyMarta Fonseca0Evaline Cheng1Duc Do2Shouvik Haldar3Shelby Kutty4Eric H. Yang5Arjun K. Ghosh6Avirup Guha7Division of Cardiology, Cardiac-Oncology Service, Bart’s Heart Centre, St Bartholomew’s Hospital West Smithfield, London, United KingdomUCLA Cardio-Oncology Program, Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, California, United StatesUCLA Cardio-Oncology Program, Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, California, United StatesDivision of Cardiology, Heart Rhythm Centre, The Royal Brompton and Harefield Hospitals, Guys & St Thomas’ NHS Foundation Trust, London, United KingdomThe Helen B. Taussig Heart Center, The Johns Hopkins Hospital and Johns Hopkins University, Baltimore, Maryland, United StatesUCLA Cardio-Oncology Program, Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, California, United StatesDivision of Cardiology, Cardiac-Oncology Service, Bart’s Heart Centre, St Bartholomew’s Hospital West Smithfield, London, United KingdomHarrington Heart and Vascular Institute, Case Western Reserve University, Cleveland, Ohio, United StatesThe relationship between bradyarrhythmias and cancer therapies has not been well described but is increasingly recognized. There have been extensive advances in oncological pharmacotherapy, with several new classes of drugs available including targeted agents, immune checkpoint inhibitors and CAR T cell therapy. This increasing repertoire of available drugs has revolutionized overall prognosis and survival of cancer patients but the true extent of their cardiovascular toxicity is only beginning to be understood. Previous studies and published reviews have traditionally focused on conventional chemotherapies and in arrhythmias in general, particularly tachyarrhythmias. The number of patients with both cancer and cardiovascular problems is increasing globally and oncologists and cardiologists need to be adept at managing arrythmia based scenarios. Greater collaboration between the two specialties including studies with prospective data collection in Cardio-Oncology are much needed to fill in knowledge gaps in this arena. This case-based review summarizes current available evidence of cancer treatment-related bradyarrhythmia incidence (including its different subtypes), possible mechanisms and outcomes. Furthermore, we propose a stepwise surveillance and management protocol for patients with suspected bradyarrhythmia related to cancer treatment.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1731907bradyarrhythmiacardio-oncologycheckpoint inhibitorsdrug–drug interactionradiation therapy |
| spellingShingle | Marta Fonseca Evaline Cheng Duc Do Shouvik Haldar Shelby Kutty Eric H. Yang Arjun K. Ghosh Avirup Guha Bradyarrhythmias in Cardio-Oncology South Asian Journal of Cancer bradyarrhythmia cardio-oncology checkpoint inhibitors drug–drug interaction radiation therapy |
| title | Bradyarrhythmias in Cardio-Oncology |
| title_full | Bradyarrhythmias in Cardio-Oncology |
| title_fullStr | Bradyarrhythmias in Cardio-Oncology |
| title_full_unstemmed | Bradyarrhythmias in Cardio-Oncology |
| title_short | Bradyarrhythmias in Cardio-Oncology |
| title_sort | bradyarrhythmias in cardio oncology |
| topic | bradyarrhythmia cardio-oncology checkpoint inhibitors drug–drug interaction radiation therapy |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1731907 |
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