Clinicopathological Differences in T2 Gallbladder Cancer According to Tumor Location
We aimed to identify clinicopathological differences and factors affecting survival outcomes of stage T2a and T2b gallbladder cancer (GBC) and validate the oncological benefits of regional lymphadenectomy and hepatic resection in these patients. This single-center study enrolled patients who were di...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2020-03-01
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| Series: | Cancer Control |
| Online Access: | https://doi.org/10.1177/1073274820915514 |
| _version_ | 1797772269085261824 |
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| author | Wan-Joon Kim MD Tae-Wan Lim MD Pyoung-Jae Park MD, PhD Sae-Byeol Choi MD, PhD Wan-Bae Kim MD, PhD |
| author_facet | Wan-Joon Kim MD Tae-Wan Lim MD Pyoung-Jae Park MD, PhD Sae-Byeol Choi MD, PhD Wan-Bae Kim MD, PhD |
| author_sort | Wan-Joon Kim MD |
| collection | DOAJ |
| description | We aimed to identify clinicopathological differences and factors affecting survival outcomes of stage T2a and T2b gallbladder cancer (GBC) and validate the oncological benefits of regional lymphadenectomy and hepatic resection in these patients. This single-center study enrolled patients who were diagnosed with pathologically confirmed T2 GBC and underwent curative resection between January 1995 and December 2017. Eighty-two patients with T2a and 50 with T2b GBCs were identified, and clinical information was retrospectively collected from medical records and analyzed. Five-year overall survival rates were 96.8% and 80.7% in T2a and T2b groups, respectively ( P = .007). Three- and 5-year survival rates among all patients with T2 GBC without and with lymph node metastasis were 97.2% and 94.4% and 81.3% and 81.3%, respectively ( P = .029). There was no difference in survival rates between the 2 groups according to whether hepatic resection was performed ( P = .320). However, in the T2b group, those who underwent hepatic resection demonstrated a better survival rate than those who did not ( P = .029). The T2b group had more multiple recurrence patterns than the T2a group, and the lymph nodes were the most common site in both groups. Multivariate analysis revealed that lymph node metastasis, vascular invasion, and tumor location were significant independent prognostic factors. Hepatic resection was not always necessary in patients with peritoneal-side GBC. Considering clinicopathological features and recurrence patterns, a systematic treatment plan, including radical resection and adjuvant treatment, should be established for hepatic-side GBC. |
| first_indexed | 2024-03-12T21:48:44Z |
| format | Article |
| id | doaj.art-eae96b4d1bbd46df82285ec4759babe5 |
| institution | Directory Open Access Journal |
| issn | 1073-2748 |
| language | English |
| last_indexed | 2024-03-12T21:48:44Z |
| publishDate | 2020-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cancer Control |
| spelling | doaj.art-eae96b4d1bbd46df82285ec4759babe52023-07-26T07:06:31ZengSAGE PublishingCancer Control1073-27482020-03-012710.1177/1073274820915514Clinicopathological Differences in T2 Gallbladder Cancer According to Tumor LocationWan-Joon Kim MD0Tae-Wan Lim MD1Pyoung-Jae Park MD, PhD2Sae-Byeol Choi MD, PhD3Wan-Bae Kim MD, PhD4 Division of Hepatobiliary Pancreas Surgery, Department of Surgery, Korea University Guro Hospital, Korea University Medical College, Seoul, Korea Division of Transplantation Vascular Surgery, Department of Surgery, Korea University Guro Hospital, Korea University Medical College, Seoul, Korea Division of Transplantation Vascular Surgery, Department of Surgery, Korea University Guro Hospital, Korea University Medical College, Seoul, Korea Division of Hepatobiliary Pancreas Surgery, Department of Surgery, Korea University Guro Hospital, Korea University Medical College, Seoul, Korea Division of Hepatobiliary Pancreas Surgery, Department of Surgery, Korea University Guro Hospital, Korea University Medical College, Seoul, KoreaWe aimed to identify clinicopathological differences and factors affecting survival outcomes of stage T2a and T2b gallbladder cancer (GBC) and validate the oncological benefits of regional lymphadenectomy and hepatic resection in these patients. This single-center study enrolled patients who were diagnosed with pathologically confirmed T2 GBC and underwent curative resection between January 1995 and December 2017. Eighty-two patients with T2a and 50 with T2b GBCs were identified, and clinical information was retrospectively collected from medical records and analyzed. Five-year overall survival rates were 96.8% and 80.7% in T2a and T2b groups, respectively ( P = .007). Three- and 5-year survival rates among all patients with T2 GBC without and with lymph node metastasis were 97.2% and 94.4% and 81.3% and 81.3%, respectively ( P = .029). There was no difference in survival rates between the 2 groups according to whether hepatic resection was performed ( P = .320). However, in the T2b group, those who underwent hepatic resection demonstrated a better survival rate than those who did not ( P = .029). The T2b group had more multiple recurrence patterns than the T2a group, and the lymph nodes were the most common site in both groups. Multivariate analysis revealed that lymph node metastasis, vascular invasion, and tumor location were significant independent prognostic factors. Hepatic resection was not always necessary in patients with peritoneal-side GBC. Considering clinicopathological features and recurrence patterns, a systematic treatment plan, including radical resection and adjuvant treatment, should be established for hepatic-side GBC.https://doi.org/10.1177/1073274820915514 |
| spellingShingle | Wan-Joon Kim MD Tae-Wan Lim MD Pyoung-Jae Park MD, PhD Sae-Byeol Choi MD, PhD Wan-Bae Kim MD, PhD Clinicopathological Differences in T2 Gallbladder Cancer According to Tumor Location Cancer Control |
| title | Clinicopathological Differences in T2 Gallbladder Cancer According to Tumor Location |
| title_full | Clinicopathological Differences in T2 Gallbladder Cancer According to Tumor Location |
| title_fullStr | Clinicopathological Differences in T2 Gallbladder Cancer According to Tumor Location |
| title_full_unstemmed | Clinicopathological Differences in T2 Gallbladder Cancer According to Tumor Location |
| title_short | Clinicopathological Differences in T2 Gallbladder Cancer According to Tumor Location |
| title_sort | clinicopathological differences in t2 gallbladder cancer according to tumor location |
| url | https://doi.org/10.1177/1073274820915514 |
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