PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz
Dephosphorylation of translation initiation factor 2 (eIF2α) terminates signalling in the mammalian integrated stress response (ISR) and has emerged as a promising target for modifying the course of protein misfolding diseases. The [(o-chlorobenzylidene)amino]guanidines (Guanabenz and Sephin1) have...
Main Authors: | Ana Crespillo-Casado, Joseph E Chambers, Peter M Fischer, Stefan J Marciniak, David Ron |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2017-04-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/26109 |
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