بررسی بیان آنتی‌ژن هسته‌ای Epstein-Barr Virus در گروهی از بیماران مبتلا به کارسینوم پاپیلاری تیروئید در شهر اصفهان
Background: Papillary thyroid carcinoma is the most prevalent malignancy of thyroid gland and is significantly lymphtropic. Epstein-Barr virus (EBV) infection may play an important role in the development of this malignancy. The aim of this study was to investigate the expression of Epstein-Barr vir...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | fas |
| Published: |
Isfahan University of Medical Sciences
2017-03-01
|
| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/6824 |
| _version_ | 1797762226370641920 |
|---|---|
| author | Mozhgan Mokhtari Mona Bahreini-Isfahani Faegheh Naji Ali Safaei |
| author_facet | Mozhgan Mokhtari Mona Bahreini-Isfahani Faegheh Naji Ali Safaei |
| author_sort | Mozhgan Mokhtari |
| collection | DOAJ |
| description | Background: Papillary thyroid carcinoma is the most prevalent malignancy of thyroid gland and is significantly lymphtropic. Epstein-Barr virus (EBV) infection may play an important role in the development of this malignancy. The aim of this study was to investigate the expression of Epstein-Barr virus nuclear antigen (EBNA), as a probable risk factor, in papillary thyroid carcinoma in a population of patients in Isfahan city, Iran, in the year 2015.
Methods: This study was performed on 43 cases of papillary thyroid carcinoma confirmed by pathologist. Using qualitative polymerase chain reaction (PCR) method in formalin-fixed paraffin-embedded tissue specimens, EBNA expression in tumor tissue was investigated. Information on age, sex, tumor size, lymph node status and metastasis were collected from the patients' medical records. The collected data were analyzed using independent t and chi-square tests via SPSS software.
Findings: EBNA antigen expression was detected in 9 cases (20.9%). The relationship between different factors and EBNA antigen expression showed a significant relationship between patients' age and gene expression (P < 0.05). In contrast, other factors were not significantly correlated with EBNA gene expression (P > 0.05).
Conclusion: According to the results of this study, Epstein-Barr virus may have a role in pathogenesis of papillary thyroid carcinoma. Further studies with control group are necessary to confirm the issue. |
| first_indexed | 2024-03-12T19:25:13Z |
| format | Article |
| id | doaj.art-eaec1e43dbf24453a4509825e44f505c |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T19:25:13Z |
| publishDate | 2017-03-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-eaec1e43dbf24453a4509825e44f505c2023-08-02T04:56:04ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2017-03-0134415164816522406بررسی بیان آنتی‌ژن هسته‌ای Epstein-Barr Virus در گروهی از بیماران مبتلا به کارسینوم پاپیلاری تیروئید در شهر اصفهانMozhgan Mokhtari0Mona Bahreini-Isfahani1Faegheh Naji2Ali Safaei3Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranGeneral Practitioner, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranGeneral Practitioner, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranStudent of Medicine, Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: Papillary thyroid carcinoma is the most prevalent malignancy of thyroid gland and is significantly lymphtropic. Epstein-Barr virus (EBV) infection may play an important role in the development of this malignancy. The aim of this study was to investigate the expression of Epstein-Barr virus nuclear antigen (EBNA), as a probable risk factor, in papillary thyroid carcinoma in a population of patients in Isfahan city, Iran, in the year 2015. Methods: This study was performed on 43 cases of papillary thyroid carcinoma confirmed by pathologist. Using qualitative polymerase chain reaction (PCR) method in formalin-fixed paraffin-embedded tissue specimens, EBNA expression in tumor tissue was investigated. Information on age, sex, tumor size, lymph node status and metastasis were collected from the patients' medical records. The collected data were analyzed using independent t and chi-square tests via SPSS software. Findings: EBNA antigen expression was detected in 9 cases (20.9%). The relationship between different factors and EBNA antigen expression showed a significant relationship between patients' age and gene expression (P < 0.05). In contrast, other factors were not significantly correlated with EBNA gene expression (P > 0.05). Conclusion: According to the results of this study, Epstein-Barr virus may have a role in pathogenesis of papillary thyroid carcinoma. Further studies with control group are necessary to confirm the issue.http://jims.mui.ac.ir/index.php/jims/article/view/6824Epstein-Barr virus (EBV)Papillary thyroid carcinomaEpstein-Barr virus nuclear antigen (EBNA) |
| spellingShingle | Mozhgan Mokhtari Mona Bahreini-Isfahani Faegheh Naji Ali Safaei بررسی بیان آنتی‌ژن هسته‌ای Epstein-Barr Virus در گروهی از بیماران مبتلا به کارسینوم پاپیلاری تیروئید در شهر اصفهان مجله دانشکده پزشکی اصفهان Epstein-Barr virus (EBV) Papillary thyroid carcinoma Epstein-Barr virus nuclear antigen (EBNA) |
| title | بررسی بیان آنتی‌ژن هسته‌ای Epstein-Barr Virus در گروهی از بیماران مبتلا به کارسینوم پاپیلاری تیروئید در شهر اصفهان |
| title_full | بررسی بیان آنتی‌ژن هسته‌ای Epstein-Barr Virus در گروهی از بیماران مبتلا به کارسینوم پاپیلاری تیروئید در شهر اصفهان |
| title_fullStr | بررسی بیان آنتی‌ژن هسته‌ای Epstein-Barr Virus در گروهی از بیماران مبتلا به کارسینوم پاپیلاری تیروئید در شهر اصفهان |
| title_full_unstemmed | بررسی بیان آنتی‌ژن هسته‌ای Epstein-Barr Virus در گروهی از بیماران مبتلا به کارسینوم پاپیلاری تیروئید در شهر اصفهان |
| title_short | بررسی بیان آنتی‌ژن هسته‌ای Epstein-Barr Virus در گروهی از بیماران مبتلا به کارسینوم پاپیلاری تیروئید در شهر اصفهان |
| title_sort | بررسی بیان آنتی‌ژن هسته‌ای epstein barr virus در گروهی از بیماران مبتلا به کارسینوم پاپیلاری تیروئید در شهر اصفهان |
| topic | Epstein-Barr virus (EBV) Papillary thyroid carcinoma Epstein-Barr virus nuclear antigen (EBNA) |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/6824 |
| work_keys_str_mv | AT mozhganmokhtari brrsybyạnậntyzẖnhsthạyepsteinbarrvirusdrgrwhyạzbymạrạnmbtlạbhḵạrsynwmpạpylạrytyrwỷyddrsẖhrạṣfhạn AT monabahreiniisfahani brrsybyạnậntyzẖnhsthạyepsteinbarrvirusdrgrwhyạzbymạrạnmbtlạbhḵạrsynwmpạpylạrytyrwỷyddrsẖhrạṣfhạn AT faeghehnaji brrsybyạnậntyzẖnhsthạyepsteinbarrvirusdrgrwhyạzbymạrạnmbtlạbhḵạrsynwmpạpylạrytyrwỷyddrsẖhrạṣfhạn AT alisafaei brrsybyạnậntyzẖnhsthạyepsteinbarrvirusdrgrwhyạzbymạrạnmbtlạbhḵạrsynwmpạpylạrytyrwỷyddrsẖhrạṣfhạn |