In Vitro and In Vivo Synergism of Fosfomycin in Combination with Meropenem or Polymyxin B against KPC-2-Producing <i>Klebsiella pneumoniae</i> Clinical Isolates

In Vitro and In Vivo Synergism of Fosfomycin in Combination with Meropenem or Polymyxin B against KPC-2-Producing <i>Klebsiella pneumoniae</i> Clinical Isolates

Fosfomycin disodium is a potential therapeutic option to manage difficult-to-treat infections, especially when combined with other antimicrobials. In this study, we evaluated the activity of fosfomycin in combination with meropenem or polymyxin B against contemporaneous KPC-2-producing <i>K. p...

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Main Authors: Aghata Cardoso da Silva Ribeiro, Yohanna Carvalho dos Santos Aoun Chikhani, Tiago Barcelos Valiatti, André Valêncio, Mariana Neri Lucas Kurihara, Fernanda Fernandes Santos, Luciene Andrade da Rocha Minarini, Ana Cristina Gales
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Antibiotics
Subjects:
fosfomycin
synergism
<i>Klebsiella pneumoniae</i>
antimicrobial resistance
<i>Galleria mellonella</i>
biofilm
Online Access:https://www.mdpi.com/2079-6382/12/2/237

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