The potentiality of the functionalized nitrogen and thiol-doped graphene quantum dots (GQDs-N-S) to stabilize the antibodies in the designing of human chorionic gonadotropin immunosensor
In this study, for the first time, a simple immunosensor for ultrasensitive recognition of Human Chorionic Gonadotropin (hCG) in serum samples was fabricated by exploiting a simple approach. In this method, a low-cost and sensitive immunosensor was fabricated based on QDs-N-S/Au nanoparticles (NPs)...
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| Format: | Article |
| Language: | English |
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Iranian Chemical Society
2019-06-01
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| Series: | Nanochemistry Research |
| Subjects: | |
| Online Access: | http://www.nanochemres.org/article_92929_0aebc1fbd6c7755bc80c0ea0d50aa4cb.pdf |
| _version_ | 1811171980297109504 |
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| author | Mahmoud Roushani Akram Valipour Mehrangiz Bahrami |
| author_facet | Mahmoud Roushani Akram Valipour Mehrangiz Bahrami |
| author_sort | Mahmoud Roushani |
| collection | DOAJ |
| description | In this study, for the first time, a simple immunosensor for ultrasensitive recognition of Human Chorionic Gonadotropin (hCG) in serum samples was fabricated by exploiting a simple approach. In this method, a low-cost and sensitive immunosensor was fabricated based on QDs-N-S/Au nanoparticles (NPs) modified Screen-Printed Carbon Electrode (SPCE). It seems that, QDs-N-S/Au NPs/ antibody as a biocomposite can be a good choice for the development of an impressive immunosensor. It must be said that in the modifying of immunosensor the length of the process have been reduced and the use of another substrates have been eliminated. pH and incubation time were optimized as two important parameters. Under the optimal conditions at modified SPCE, a linear communication in the range of 0.1 to 125 pg mL−1 and the detection limit of 12.5 fg mL−1 were obtained. The present procedure was utilized to the detection of hCG in real samples with the desirable results. |
| first_indexed | 2024-04-10T17:24:19Z |
| format | Article |
| id | doaj.art-eaec97ebbd604251a25da7689e968959 |
| institution | Directory Open Access Journal |
| issn | 2538-4279 2423-818X |
| language | English |
| last_indexed | 2024-04-10T17:24:19Z |
| publishDate | 2019-06-01 |
| publisher | Iranian Chemical Society |
| record_format | Article |
| series | Nanochemistry Research |
| spelling | doaj.art-eaec97ebbd604251a25da7689e9689592023-02-05T07:22:52ZengIranian Chemical SocietyNanochemistry Research2538-42792423-818X2019-06-0141202610.22036/ncr.2019.01.00392929The potentiality of the functionalized nitrogen and thiol-doped graphene quantum dots (GQDs-N-S) to stabilize the antibodies in the designing of human chorionic gonadotropin immunosensorMahmoud Roushani0Akram Valipour1Mehrangiz Bahrami2Department of Chemistry, Ilam University, Ilam, IranDepartment of Chemistry, Ilam University, Ilam, IranDepartment of Chemistry, Yasouj University, Yasouj, IranIn this study, for the first time, a simple immunosensor for ultrasensitive recognition of Human Chorionic Gonadotropin (hCG) in serum samples was fabricated by exploiting a simple approach. In this method, a low-cost and sensitive immunosensor was fabricated based on QDs-N-S/Au nanoparticles (NPs) modified Screen-Printed Carbon Electrode (SPCE). It seems that, QDs-N-S/Au NPs/ antibody as a biocomposite can be a good choice for the development of an impressive immunosensor. It must be said that in the modifying of immunosensor the length of the process have been reduced and the use of another substrates have been eliminated. pH and incubation time were optimized as two important parameters. Under the optimal conditions at modified SPCE, a linear communication in the range of 0.1 to 125 pg mL−1 and the detection limit of 12.5 fg mL−1 were obtained. The present procedure was utilized to the detection of hCG in real samples with the desirable results.http://www.nanochemres.org/article_92929_0aebc1fbd6c7755bc80c0ea0d50aa4cb.pdfscreen printed carbon electrodenitrogen and thiol-doped graphene quantum dotsimmunosensor |
| spellingShingle | Mahmoud Roushani Akram Valipour Mehrangiz Bahrami The potentiality of the functionalized nitrogen and thiol-doped graphene quantum dots (GQDs-N-S) to stabilize the antibodies in the designing of human chorionic gonadotropin immunosensor Nanochemistry Research screen printed carbon electrode nitrogen and thiol-doped graphene quantum dots immunosensor |
| title | The potentiality of the functionalized nitrogen and thiol-doped graphene quantum dots (GQDs-N-S) to stabilize the antibodies in the designing of human chorionic gonadotropin immunosensor |
| title_full | The potentiality of the functionalized nitrogen and thiol-doped graphene quantum dots (GQDs-N-S) to stabilize the antibodies in the designing of human chorionic gonadotropin immunosensor |
| title_fullStr | The potentiality of the functionalized nitrogen and thiol-doped graphene quantum dots (GQDs-N-S) to stabilize the antibodies in the designing of human chorionic gonadotropin immunosensor |
| title_full_unstemmed | The potentiality of the functionalized nitrogen and thiol-doped graphene quantum dots (GQDs-N-S) to stabilize the antibodies in the designing of human chorionic gonadotropin immunosensor |
| title_short | The potentiality of the functionalized nitrogen and thiol-doped graphene quantum dots (GQDs-N-S) to stabilize the antibodies in the designing of human chorionic gonadotropin immunosensor |
| title_sort | potentiality of the functionalized nitrogen and thiol doped graphene quantum dots gqds n s to stabilize the antibodies in the designing of human chorionic gonadotropin immunosensor |
| topic | screen printed carbon electrode nitrogen and thiol-doped graphene quantum dots immunosensor |
| url | http://www.nanochemres.org/article_92929_0aebc1fbd6c7755bc80c0ea0d50aa4cb.pdf |
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