Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions
Peroxisome proliferator-activated receptors (PPARs) are the nuclear receptors that could mediate the nutrient-dependent transcriptional activation and regulate metabolic networks through energy homeostasis. However, these receptors cannot work properly under metabolic stress. PPARs and their subtype...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-11-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/22/12463 |
| _version_ | 1797510029925941248 |
|---|---|
| author | Faiz-ul Hassan Asif Nadeem Zhipeng Li Maryam Javed Qingyou Liu Jahanzaib Azhar Muhammad Saif-ur Rehman Kuiqing Cui Saif ur Rehman |
| author_facet | Faiz-ul Hassan Asif Nadeem Zhipeng Li Maryam Javed Qingyou Liu Jahanzaib Azhar Muhammad Saif-ur Rehman Kuiqing Cui Saif ur Rehman |
| author_sort | Faiz-ul Hassan |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptors (PPARs) are the nuclear receptors that could mediate the nutrient-dependent transcriptional activation and regulate metabolic networks through energy homeostasis. However, these receptors cannot work properly under metabolic stress. PPARs and their subtypes can be modulated by nutrigenomic interventions, particularly under stress conditions to restore cellular homeostasis. Many nutrients such as polyunsaturated fatty acids, vitamins, dietary amino acids and phytochemicals have shown their ability for potential activation or inhibition of PPARs. Thus, through different mechanisms, all these nutrients can modulate PPARs and are ultimately helpful to prevent various metabolic disorders, particularly in transition dairy cows. This review aims to provide insights into the crucial role of PPARs in energy metabolism and their potential modulation through nutrigenomic interventions to improve energy homeostasis in dairy animals. |
| first_indexed | 2024-03-10T05:26:07Z |
| format | Article |
| id | doaj.art-eaedddb305f64186a88655f6c35a3777 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T05:26:07Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-eaedddb305f64186a88655f6c35a37772023-11-22T23:42:42ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-11-0122221246310.3390/ijms222212463Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic InterventionsFaiz-ul Hassan0Asif Nadeem1Zhipeng Li2Maryam Javed3Qingyou Liu4Jahanzaib Azhar5Muhammad Saif-ur Rehman6Kuiqing Cui7Saif ur Rehman8State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning 530005, ChinaDepartment of Biotechnology, Virtual University of Pakistan, Lahore 54000, PakistanState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning 530005, ChinaInstitute of Biochemistry and Biotechnology, University of Veterinary and Animal Sciences Lahore, Lahore 54000, PakistanState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning 530005, ChinaDepartment of Biotechnology, Virtual University of Pakistan, Lahore 54000, PakistanInstitute of Animal and Dairy Sciences, Faculty of Animal Husbandry, University of Agriculture, Faisalabad 38040, PakistanState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning 530005, ChinaState Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning 530005, ChinaPeroxisome proliferator-activated receptors (PPARs) are the nuclear receptors that could mediate the nutrient-dependent transcriptional activation and regulate metabolic networks through energy homeostasis. However, these receptors cannot work properly under metabolic stress. PPARs and their subtypes can be modulated by nutrigenomic interventions, particularly under stress conditions to restore cellular homeostasis. Many nutrients such as polyunsaturated fatty acids, vitamins, dietary amino acids and phytochemicals have shown their ability for potential activation or inhibition of PPARs. Thus, through different mechanisms, all these nutrients can modulate PPARs and are ultimately helpful to prevent various metabolic disorders, particularly in transition dairy cows. This review aims to provide insights into the crucial role of PPARs in energy metabolism and their potential modulation through nutrigenomic interventions to improve energy homeostasis in dairy animals.https://www.mdpi.com/1422-0067/22/22/12463nuclear receptorsPPARsnutrigenomicsenergy homeostasisdairy animals |
| spellingShingle | Faiz-ul Hassan Asif Nadeem Zhipeng Li Maryam Javed Qingyou Liu Jahanzaib Azhar Muhammad Saif-ur Rehman Kuiqing Cui Saif ur Rehman Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions International Journal of Molecular Sciences nuclear receptors PPARs nutrigenomics energy homeostasis dairy animals |
| title | Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions |
| title_full | Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions |
| title_fullStr | Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions |
| title_full_unstemmed | Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions |
| title_short | Role of Peroxisome Proliferator-Activated Receptors (PPARs) in Energy Homeostasis of Dairy Animals: Exploiting Their Modulation through Nutrigenomic Interventions |
| title_sort | role of peroxisome proliferator activated receptors ppars in energy homeostasis of dairy animals exploiting their modulation through nutrigenomic interventions |
| topic | nuclear receptors PPARs nutrigenomics energy homeostasis dairy animals |
| url | https://www.mdpi.com/1422-0067/22/22/12463 |
| work_keys_str_mv | AT faizulhassan roleofperoxisomeproliferatoractivatedreceptorspparsinenergyhomeostasisofdairyanimalsexploitingtheirmodulationthroughnutrigenomicinterventions AT asifnadeem roleofperoxisomeproliferatoractivatedreceptorspparsinenergyhomeostasisofdairyanimalsexploitingtheirmodulationthroughnutrigenomicinterventions AT zhipengli roleofperoxisomeproliferatoractivatedreceptorspparsinenergyhomeostasisofdairyanimalsexploitingtheirmodulationthroughnutrigenomicinterventions AT maryamjaved roleofperoxisomeproliferatoractivatedreceptorspparsinenergyhomeostasisofdairyanimalsexploitingtheirmodulationthroughnutrigenomicinterventions AT qingyouliu roleofperoxisomeproliferatoractivatedreceptorspparsinenergyhomeostasisofdairyanimalsexploitingtheirmodulationthroughnutrigenomicinterventions AT jahanzaibazhar roleofperoxisomeproliferatoractivatedreceptorspparsinenergyhomeostasisofdairyanimalsexploitingtheirmodulationthroughnutrigenomicinterventions AT muhammadsaifurrehman roleofperoxisomeproliferatoractivatedreceptorspparsinenergyhomeostasisofdairyanimalsexploitingtheirmodulationthroughnutrigenomicinterventions AT kuiqingcui roleofperoxisomeproliferatoractivatedreceptorspparsinenergyhomeostasisofdairyanimalsexploitingtheirmodulationthroughnutrigenomicinterventions AT saifurrehman roleofperoxisomeproliferatoractivatedreceptorspparsinenergyhomeostasisofdairyanimalsexploitingtheirmodulationthroughnutrigenomicinterventions |