A randomized, double-blind trial on the bioavailability of two CoQ10 formulations
The bioavailability of a single, 100 mg, dose of reduced Coenzyme Q10 (CoQH-CF) and Coenzyme Q10 formulation was compared in individuals of >60 years. Significantly higher (P < 0.001) plasma concentrations were demonstrated for the CoQH-CF formulation at 5, 6, 8, 12, 24, 48 and 72 h post-dose...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2009-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S175646460800011X |
| _version_ | 1818690615800496128 |
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| author | Malkanthi Evans Joshua Baisley Sonya Barss Najla Guthrie |
| author_facet | Malkanthi Evans Joshua Baisley Sonya Barss Najla Guthrie |
| author_sort | Malkanthi Evans |
| collection | DOAJ |
| description | The bioavailability of a single, 100 mg, dose of reduced Coenzyme Q10 (CoQH-CF) and Coenzyme Q10 formulation was compared in individuals of >60 years. Significantly higher (P < 0.001) plasma concentrations were demonstrated for the CoQH-CF formulation at 5, 6, 8, 12, 24, 48 and 72 h post-dose compared to the CoQ10 formulation. The area under the curve (AUC) of reduced and total Coenzyme Q10 was significantly higher (P < 0.001) in subjects administered CoQH-CF resulting in 4.3-fold higher plasma AUC0–72 h (430% increase) in subjects receiving CoQH-CF compared to subjects receiving Coenzyme Q10. Oxidized Coenzyme Q10 in plasma was higher (P < 0.001) in subjects receiving CoQH-CF compared to subjects receiving Coenzyme Q10 resulting in a 3.3-fold higher plasma AUC0–72 h (329% increase). Total CoQ10 reached maximum plasma concentrations 15.5 ± 19.6 h after supplementation with CoQH-CF and 26.5 ± 25.8 h after supplementation with Coenzyme Q10, respectively. Thus, reduced Coenzyme Q10 liquid soft gel formulation was found to be superior to the commercial formulation of Coenzyme Q10 for bioavailability. |
| first_indexed | 2024-12-17T12:28:49Z |
| format | Article |
| id | doaj.art-eaee28c084d14f7c847e42ac723cb327 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-17T12:28:49Z |
| publishDate | 2009-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-eaee28c084d14f7c847e42ac723cb3272022-12-21T21:48:41ZengElsevierJournal of Functional Foods1756-46462009-01-01116573A randomized, double-blind trial on the bioavailability of two CoQ10 formulationsMalkanthi Evans0Joshua Baisley1Sonya Barss2Najla Guthrie3Corresponding author: Tel.: +1 519 438 9374x239; fax: +1 519 438 8314.; KGK Synergize Inc., Suite 1440, One London Place, 255 Queens Avenue, London, ON, Canada N6A 5R8KGK Synergize Inc., Suite 1440, One London Place, 255 Queens Avenue, London, ON, Canada N6A 5R8KGK Synergize Inc., Suite 1440, One London Place, 255 Queens Avenue, London, ON, Canada N6A 5R8KGK Synergize Inc., Suite 1440, One London Place, 255 Queens Avenue, London, ON, Canada N6A 5R8The bioavailability of a single, 100 mg, dose of reduced Coenzyme Q10 (CoQH-CF) and Coenzyme Q10 formulation was compared in individuals of >60 years. Significantly higher (P < 0.001) plasma concentrations were demonstrated for the CoQH-CF formulation at 5, 6, 8, 12, 24, 48 and 72 h post-dose compared to the CoQ10 formulation. The area under the curve (AUC) of reduced and total Coenzyme Q10 was significantly higher (P < 0.001) in subjects administered CoQH-CF resulting in 4.3-fold higher plasma AUC0–72 h (430% increase) in subjects receiving CoQH-CF compared to subjects receiving Coenzyme Q10. Oxidized Coenzyme Q10 in plasma was higher (P < 0.001) in subjects receiving CoQH-CF compared to subjects receiving Coenzyme Q10 resulting in a 3.3-fold higher plasma AUC0–72 h (329% increase). Total CoQ10 reached maximum plasma concentrations 15.5 ± 19.6 h after supplementation with CoQH-CF and 26.5 ± 25.8 h after supplementation with Coenzyme Q10, respectively. Thus, reduced Coenzyme Q10 liquid soft gel formulation was found to be superior to the commercial formulation of Coenzyme Q10 for bioavailability.http://www.sciencedirect.com/science/article/pii/S175646460800011XCoenzyme Q10Reduced Coenzyme Q10Bioavailability |
| spellingShingle | Malkanthi Evans Joshua Baisley Sonya Barss Najla Guthrie A randomized, double-blind trial on the bioavailability of two CoQ10 formulations Journal of Functional Foods Coenzyme Q10 Reduced Coenzyme Q10 Bioavailability |
| title | A randomized, double-blind trial on the bioavailability of two CoQ10 formulations |
| title_full | A randomized, double-blind trial on the bioavailability of two CoQ10 formulations |
| title_fullStr | A randomized, double-blind trial on the bioavailability of two CoQ10 formulations |
| title_full_unstemmed | A randomized, double-blind trial on the bioavailability of two CoQ10 formulations |
| title_short | A randomized, double-blind trial on the bioavailability of two CoQ10 formulations |
| title_sort | randomized double blind trial on the bioavailability of two coq10 formulations |
| topic | Coenzyme Q10 Reduced Coenzyme Q10 Bioavailability |
| url | http://www.sciencedirect.com/science/article/pii/S175646460800011X |
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