Multidrug-resistant Acinetobacter spp. from hospital intensive care units in Brazilian Amazon
Acinetobacter spp. are one of the main pathogens responsible for healthcare-associated infections and are associated with high rates of morbidity and mortality globally, mainly because of their high capacity to present and develop resistance to antimicrobials. To identify species of the Acinetobacte...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867023009479 |
| _version_ | 1797391959124344832 |
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| author | Marcos Eduardo Passos da Silva Maicon Aleandro da Silva Gomes Renata Santos Rodrigues Nucia Cristiane da Silva Lima Anjo Gabriel Carvalho Roger Lafontaine Mesquita Taborda Najla Benevides Matos |
| author_facet | Marcos Eduardo Passos da Silva Maicon Aleandro da Silva Gomes Renata Santos Rodrigues Nucia Cristiane da Silva Lima Anjo Gabriel Carvalho Roger Lafontaine Mesquita Taborda Najla Benevides Matos |
| author_sort | Marcos Eduardo Passos da Silva |
| collection | DOAJ |
| description | Acinetobacter spp. are one of the main pathogens responsible for healthcare-associated infections and are associated with high rates of morbidity and mortality globally, mainly because of their high capacity to present and develop resistance to antimicrobials. To identify species of the Acinetobacter and their resistance profiles from samples collected from hospitalized patients, health professionals and hospital environmental sources in the intensive care units of different public reference hospitals in Porto Velho City, Rondônia, Western Brazilian Amazon. Isolates were identified using microbiological and molecular techniques. The antimicrobial susceptibility profile was determined by disk diffusion. A total of 201 Acinetobacter spp. isolates were identified, of which 47.3% originated from hospital structures, 46.8% from patients and 6% from healthcare professionals. A. baumannii and A. nosocomialis were the most prevalent, with frequency of 58.7% and 31.8%, respectively. Regarding the susceptibility profile, it was observed that 56.3% were classified as multidrug-resistant and 76.2% of the samples belonging to A. baumannii were resistant to carbapenems. In contrast, 96.9% were susceptible to polymyxin B and 91.3% to doxycycline. The data presented here can be used to guide and strengthen the control of multidrug-resistant infections caused by Acinetobacter spp., in addition to improving providing information from a traditionally unassisted region of Brazil. |
| first_indexed | 2024-03-08T23:40:16Z |
| format | Article |
| id | doaj.art-eaeea1ff9ea341e9b140e34c61c26c41 |
| institution | Directory Open Access Journal |
| issn | 1413-8670 |
| language | English |
| last_indexed | 2024-03-08T23:40:16Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-eaeea1ff9ea341e9b140e34c61c26c412023-12-14T05:20:47ZengElsevierBrazilian Journal of Infectious Diseases1413-86702023-11-01276103687Multidrug-resistant Acinetobacter spp. from hospital intensive care units in Brazilian AmazonMarcos Eduardo Passos da Silva0Maicon Aleandro da Silva Gomes1Renata Santos Rodrigues2Nucia Cristiane da Silva Lima3Anjo Gabriel Carvalho4Roger Lafontaine Mesquita Taborda5Najla Benevides Matos6Fundação Oswaldo Cruz (FIOCRUZ/RO), Laboratório de Microbiologia, Porto Velho, RO, Brazil; Universidade Federal de Rondônia (UNIR), Porto Velho, RO, Brazil; Programa de Pós-Graduação em Biologia Experimental, Porto Velho, RO, BrazilUniversidade Federal de Rondônia (UNIR), Porto Velho, RO, BrazilInstituto Oswaldo Cruz (IOC), Programa de Pós-graduação em Biologia Celular e Molecular (PGBCM), Fiocruz, Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz (FIOCRUZ/RO), Laboratório de Microbiologia, Porto Velho, RO, Brazil; Centro de Pesquisa em Medicina Tropical de Rondônia (CEPEM), Porto Velho, RO, BrazilFundação Oswaldo Cruz (FIOCRUZ/RO), Laboratório de Microbiologia, Porto Velho, RO, Brazil; Universidade Federal de Rondônia (UNIR), Porto Velho, RO, Brazil; Programa de Pós-Graduação em Biologia Experimental, Porto Velho, RO, BrazilCentro de Pesquisa em Medicina Tropical de Rondônia (CEPEM), Porto Velho, RO, BrazilFundação Oswaldo Cruz (FIOCRUZ/RO), Laboratório de Microbiologia, Porto Velho, RO, Brazil; Universidade Federal de Rondônia (UNIR), Porto Velho, RO, Brazil; Programa de Pós-Graduação em Biologia Experimental, Porto Velho, RO, Brazil; Centro de Pesquisa em Medicina Tropical de Rondônia (CEPEM), Porto Velho, RO, Brazil; Instituto Nacional de Epidemiologia na Amazônia Ocidental (INCT-EPIAMO), Porto Velho, RO, Brazil; Corresponding author.Acinetobacter spp. are one of the main pathogens responsible for healthcare-associated infections and are associated with high rates of morbidity and mortality globally, mainly because of their high capacity to present and develop resistance to antimicrobials. To identify species of the Acinetobacter and their resistance profiles from samples collected from hospitalized patients, health professionals and hospital environmental sources in the intensive care units of different public reference hospitals in Porto Velho City, Rondônia, Western Brazilian Amazon. Isolates were identified using microbiological and molecular techniques. The antimicrobial susceptibility profile was determined by disk diffusion. A total of 201 Acinetobacter spp. isolates were identified, of which 47.3% originated from hospital structures, 46.8% from patients and 6% from healthcare professionals. A. baumannii and A. nosocomialis were the most prevalent, with frequency of 58.7% and 31.8%, respectively. Regarding the susceptibility profile, it was observed that 56.3% were classified as multidrug-resistant and 76.2% of the samples belonging to A. baumannii were resistant to carbapenems. In contrast, 96.9% were susceptible to polymyxin B and 91.3% to doxycycline. The data presented here can be used to guide and strengthen the control of multidrug-resistant infections caused by Acinetobacter spp., in addition to improving providing information from a traditionally unassisted region of Brazil.http://www.sciencedirect.com/science/article/pii/S1413867023009479Antibiotic resistance profileAcinetobacter spp.Intensive care unitsPorto Velho Brazilian Amazon |
| spellingShingle | Marcos Eduardo Passos da Silva Maicon Aleandro da Silva Gomes Renata Santos Rodrigues Nucia Cristiane da Silva Lima Anjo Gabriel Carvalho Roger Lafontaine Mesquita Taborda Najla Benevides Matos Multidrug-resistant Acinetobacter spp. from hospital intensive care units in Brazilian Amazon Brazilian Journal of Infectious Diseases Antibiotic resistance profile Acinetobacter spp. Intensive care units Porto Velho Brazilian Amazon |
| title | Multidrug-resistant Acinetobacter spp. from hospital intensive care units in Brazilian Amazon |
| title_full | Multidrug-resistant Acinetobacter spp. from hospital intensive care units in Brazilian Amazon |
| title_fullStr | Multidrug-resistant Acinetobacter spp. from hospital intensive care units in Brazilian Amazon |
| title_full_unstemmed | Multidrug-resistant Acinetobacter spp. from hospital intensive care units in Brazilian Amazon |
| title_short | Multidrug-resistant Acinetobacter spp. from hospital intensive care units in Brazilian Amazon |
| title_sort | multidrug resistant acinetobacter spp from hospital intensive care units in brazilian amazon |
| topic | Antibiotic resistance profile Acinetobacter spp. Intensive care units Porto Velho Brazilian Amazon |
| url | http://www.sciencedirect.com/science/article/pii/S1413867023009479 |
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