Ibuprofen and paracetamol for patent ductus arteriosus
We aimed to assess the state of the art of pharmacological treatment of patency of ductus arteriosus (PDA) with ibuprofen and paracetamol in preterm infants. We pointed out that ibuprofen is the first choice drug for PDA treatment and indomethacin should be abandoned for its frequent adverse effects...
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| Format: | Article |
| Language: | English |
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Hygeia Press di Corridori Marinella
2014-09-01
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| Series: | Journal of Pediatric and Neonatal Individualized Medicine |
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| Online Access: | https://www.jpnim.com/index.php/jpnim/article/view/171 |
| _version_ | 1828527528539586560 |
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| author | Carlo Dani |
| author_facet | Carlo Dani |
| author_sort | Carlo Dani |
| collection | DOAJ |
| description | We aimed to assess the state of the art of pharmacological treatment of patency of ductus arteriosus (PDA) with ibuprofen and paracetamol in preterm infants. We pointed out that ibuprofen is the first choice drug for PDA treatment and indomethacin should be abandoned for its frequent adverse effects. However, also the pharmacological prevention of PDA should be abandoned because many preterm infants have spontaneous closure of PDA and ibuprofen may have dangerous adverse effects. Oral paracetamol has been found in two randomized controlled studies to have the same effectiveness of ibuprofen in closing PDA but without toxicity. If these data will be confirmed the management of PDA in preterm infants should be re-evaluated.
Proceedings of the 10th International Workshop on Neonatology · Cagliari (Italy) · October 22nd-25th, 2014 · The last ten years, the next ten years in Neonatology
Guest Editors: Vassilios Fanos, Michele Mussap, Gavino Faa, Apostolos Papageorgiou |
| first_indexed | 2024-12-11T21:39:45Z |
| format | Article |
| id | doaj.art-eaeff64ca9a646d1981f6c562018467a |
| institution | Directory Open Access Journal |
| issn | 2281-0692 |
| language | English |
| last_indexed | 2024-12-11T21:39:45Z |
| publishDate | 2014-09-01 |
| publisher | Hygeia Press di Corridori Marinella |
| record_format | Article |
| series | Journal of Pediatric and Neonatal Individualized Medicine |
| spelling | doaj.art-eaeff64ca9a646d1981f6c562018467a2022-12-22T00:49:52ZengHygeia Press di Corridori MarinellaJournal of Pediatric and Neonatal Individualized Medicine2281-06922014-09-0132e030226e03022610.7363/030226137Ibuprofen and paracetamol for patent ductus arteriosusCarlo Dani0Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, ItalyWe aimed to assess the state of the art of pharmacological treatment of patency of ductus arteriosus (PDA) with ibuprofen and paracetamol in preterm infants. We pointed out that ibuprofen is the first choice drug for PDA treatment and indomethacin should be abandoned for its frequent adverse effects. However, also the pharmacological prevention of PDA should be abandoned because many preterm infants have spontaneous closure of PDA and ibuprofen may have dangerous adverse effects. Oral paracetamol has been found in two randomized controlled studies to have the same effectiveness of ibuprofen in closing PDA but without toxicity. If these data will be confirmed the management of PDA in preterm infants should be re-evaluated. Proceedings of the 10th International Workshop on Neonatology · Cagliari (Italy) · October 22nd-25th, 2014 · The last ten years, the next ten years in Neonatology Guest Editors: Vassilios Fanos, Michele Mussap, Gavino Faa, Apostolos Papageorgiouhttps://www.jpnim.com/index.php/jpnim/article/view/171ductus arteriosusibuprofenparacetamolpreterm infant |
| spellingShingle | Carlo Dani Ibuprofen and paracetamol for patent ductus arteriosus Journal of Pediatric and Neonatal Individualized Medicine ductus arteriosus ibuprofen paracetamol preterm infant |
| title | Ibuprofen and paracetamol for patent ductus arteriosus |
| title_full | Ibuprofen and paracetamol for patent ductus arteriosus |
| title_fullStr | Ibuprofen and paracetamol for patent ductus arteriosus |
| title_full_unstemmed | Ibuprofen and paracetamol for patent ductus arteriosus |
| title_short | Ibuprofen and paracetamol for patent ductus arteriosus |
| title_sort | ibuprofen and paracetamol for patent ductus arteriosus |
| topic | ductus arteriosus ibuprofen paracetamol preterm infant |
| url | https://www.jpnim.com/index.php/jpnim/article/view/171 |
| work_keys_str_mv | AT carlodani ibuprofenandparacetamolforpatentductusarteriosus |