Apolipoprotein E ε4 is superior to apolipoprotein E ε2 in predicting cognitive scores over 30 months
Paul Regal, Balakrishnan Nair, Eileen Hetherington Geriatric Medicine and Gerontology, University of Newcastle, Callaghan, NSW, Australia Background: The purpose of this study was to compare apolipoprotein E ε4 (Apo E ε4) and apolipoprotein E ε2 (Apo E &epsil...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2013-11-01
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| Series: | Clinical Interventions in Aging |
| Subjects: | |
| Online Access: | https://www.dovepress.com/apolipoprotein-e-epsilon4-is-superior-to-apolipoprotein-e-epsilon2-in--peer-reviewed-article-CIA |
| _version_ | 1818842566123061248 |
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| author | Regal P Nair B Hetherington E |
| author_facet | Regal P Nair B Hetherington E |
| author_sort | Regal P |
| collection | DOAJ |
| description | Paul Regal, Balakrishnan Nair, Eileen Hetherington Geriatric Medicine and Gerontology, University of Newcastle, Callaghan, NSW, Australia Background: The purpose of this study was to compare apolipoprotein E ε4 (Apo E ε4) and apolipoprotein E ε2 (Apo E ε2) as predictors of cognitive and functional trajectories over 30 months. Methods: This prospective cohort study included 287 community-dwelling memory clinic patients with dementia, mild cognitive impairment, or no cognitive impairment. The Addenbrooke Cognitive Assessment, Mini-Mental State Examination, Montreal Cognitive Assessment, Delirium Index, and Nottingham Instrumental Activities of Daily Living tests were administered to each subject. Results: One hundred and nine subjects (40%) carried Apo E ε4 and 48 (16.7%) carried Apo E ε2. One hundred and nine ε4-positive subjects differed significantly from 178 ε4-negative subjects in 19/52 comparisons (36.5%), whereas 46 Apo E ε2-positive subjects had 0/52 significant differences from 239 ε2-negative subjects (P < 0.0001). The variables most affected by ε4 were the Delirium Index and Mini-Mental State Examination. Instrumental Activities of Daily Living score and residence were unrelated to Apo E ε4 or ε2. Conclusion: Apo E ε4 positivity predicted four cognitive scores measured every 6 months over 30 months. Apo E ε2 scores predicted none of 52 comparisons. Keywords: apolipoprotein E genotype, dementia, mild cognitive impairment |
| first_indexed | 2024-12-19T04:44:00Z |
| format | Article |
| id | doaj.art-eaf088f09c294782859c3a41bc331c09 |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-12-19T04:44:00Z |
| publishDate | 2013-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-eaf088f09c294782859c3a41bc331c092022-12-21T20:35:32ZengDove Medical PressClinical Interventions in Aging1178-19982013-11-01Volume 81461146514853Apolipoprotein E ε4 is superior to apolipoprotein E ε2 in predicting cognitive scores over 30 monthsRegal PNair BHetherington EPaul Regal, Balakrishnan Nair, Eileen Hetherington Geriatric Medicine and Gerontology, University of Newcastle, Callaghan, NSW, Australia Background: The purpose of this study was to compare apolipoprotein E ε4 (Apo E ε4) and apolipoprotein E ε2 (Apo E ε2) as predictors of cognitive and functional trajectories over 30 months. Methods: This prospective cohort study included 287 community-dwelling memory clinic patients with dementia, mild cognitive impairment, or no cognitive impairment. The Addenbrooke Cognitive Assessment, Mini-Mental State Examination, Montreal Cognitive Assessment, Delirium Index, and Nottingham Instrumental Activities of Daily Living tests were administered to each subject. Results: One hundred and nine subjects (40%) carried Apo E ε4 and 48 (16.7%) carried Apo E ε2. One hundred and nine ε4-positive subjects differed significantly from 178 ε4-negative subjects in 19/52 comparisons (36.5%), whereas 46 Apo E ε2-positive subjects had 0/52 significant differences from 239 ε2-negative subjects (P < 0.0001). The variables most affected by ε4 were the Delirium Index and Mini-Mental State Examination. Instrumental Activities of Daily Living score and residence were unrelated to Apo E ε4 or ε2. Conclusion: Apo E ε4 positivity predicted four cognitive scores measured every 6 months over 30 months. Apo E ε2 scores predicted none of 52 comparisons. Keywords: apolipoprotein E genotype, dementia, mild cognitive impairmenthttps://www.dovepress.com/apolipoprotein-e-epsilon4-is-superior-to-apolipoprotein-e-epsilon2-in--peer-reviewed-article-CIAApo E genotypedementiamild cognitive impairment |
| spellingShingle | Regal P Nair B Hetherington E Apolipoprotein E ε4 is superior to apolipoprotein E ε2 in predicting cognitive scores over 30 months Clinical Interventions in Aging Apo E genotype dementia mild cognitive impairment |
| title | Apolipoprotein E ε4 is superior to apolipoprotein E ε2 in predicting cognitive scores over 30 months |
| title_full | Apolipoprotein E ε4 is superior to apolipoprotein E ε2 in predicting cognitive scores over 30 months |
| title_fullStr | Apolipoprotein E ε4 is superior to apolipoprotein E ε2 in predicting cognitive scores over 30 months |
| title_full_unstemmed | Apolipoprotein E ε4 is superior to apolipoprotein E ε2 in predicting cognitive scores over 30 months |
| title_short | Apolipoprotein E ε4 is superior to apolipoprotein E ε2 in predicting cognitive scores over 30 months |
| title_sort | apolipoprotein e epsilon 4 is superior to apolipoprotein e epsilon 2 in predicting cognitive scores over 30 months |
| topic | Apo E genotype dementia mild cognitive impairment |
| url | https://www.dovepress.com/apolipoprotein-e-epsilon4-is-superior-to-apolipoprotein-e-epsilon2-in--peer-reviewed-article-CIA |
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