A loss-of-function variant in SSFA2 causes male infertility with globozoospermia and failed oocyte activation

A loss-of-function variant in SSFA2 causes male infertility with globozoospermia and failed oocyte activation

Abstract Globozoospermia (OMIM: 102530) is a rare type of teratozoospermia (< 0.1%). The etiology of globozoospermia is complicated and has not been fully revealed. Here, we report an infertile patient with globozoospermia. Variational analysis revealed a homozygous missense variant in the SSFA2...

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Bibliographic Details
Main Authors: Gelin Huang, Xueguang Zhang, Guanping Yao, Lin Huang, Sixian Wu, Xiaoliang Li, Juncen Guo, Yuting Wen, Yan Wang, Lijun Shang, Na Li, Wenming Xu
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Reproductive Biology and Endocrinology
Subjects:
SSFA2
Globozoospermia
Male infertility
AOA-ICSI
Oocyte activation failure
Online Access:https://doi.org/10.1186/s12958-022-00976-5

Internet

https://doi.org/10.1186/s12958-022-00976-5

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