Long term survival with the combination of interferon and chemotherapy in metastatic melanoma
The prognosis of metastatic melanoma is poor. Pre-targeted treatment era, the combination of interferon-α (IF-α) plus chemotherapy had been used and have generally short response duration. Herein, we present a metastatic melanoma case that achieved long-term durable complete response (CR) IF-α plus...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2015-09-01
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| Series: | Journal of the Egyptian National Cancer Institute |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1110036215000102 |
| _version_ | 1819169153695612928 |
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| author | Bülent Karagöz Oğuz Bilgi Alpaslan Özgün Levent Emirzeoğlu Serkan Çelik Ahmet Özet |
| author_facet | Bülent Karagöz Oğuz Bilgi Alpaslan Özgün Levent Emirzeoğlu Serkan Çelik Ahmet Özet |
| author_sort | Bülent Karagöz |
| collection | DOAJ |
| description | The prognosis of metastatic melanoma is poor. Pre-targeted treatment era, the combination of interferon-α (IF-α) plus chemotherapy had been used and have generally short response duration. Herein, we present a metastatic melanoma case that achieved long-term durable complete response (CR) IF-α plus chemotherapy and IF-α maintenance therapy and had lower Regulatory T (Treg) cells. A fifty-year old woman was admitted to the hospital with metastatic melanoma. Lactate dehydrogenase (LDH) level was 660 U/L. The percentage of CD4+CD25+ Treg cells was 2.4% in CD4+ lymphocytes. The IF-α plus chemotherapy and IF-α maintenance were administered. After six courses of chemotherapy, CR was achieved. Vitiligo and hypothyroidism occurred. The patient has remained in CR for approximately 7 years until second pleural metastases were detected and death. The patient has positive prognostic factors such as induction of autoimmunity, small tumor volume, mild elevated LDH level, and lower Treg cell percentage. She survived long term with CR after IF-α treatment with concurrent chemotherapy and maintenance. IF-α plus chemotherapy may be a treatment option for metastatic melanoma in selected cases who cannot reach new targeted drugs. |
| first_indexed | 2024-12-22T19:14:59Z |
| format | Article |
| id | doaj.art-eaf578311c144b51b0a3b16980bd499c |
| institution | Directory Open Access Journal |
| issn | 1110-0362 |
| language | English |
| last_indexed | 2024-12-22T19:14:59Z |
| publishDate | 2015-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of the Egyptian National Cancer Institute |
| spelling | doaj.art-eaf578311c144b51b0a3b16980bd499c2022-12-21T18:15:32ZengSpringerOpenJournal of the Egyptian National Cancer Institute1110-03622015-09-0127316116310.1016/j.jnci.2015.02.004Long term survival with the combination of interferon and chemotherapy in metastatic melanomaBülent Karagöz0Oğuz Bilgi1Alpaslan Özgün2Levent Emirzeoğlu3Serkan Çelik4Ahmet Özet5Department of Medical Oncology, GATA Haydarpasa Hospital, Istanbul, TurkeyDepartment of Medical Oncology, GATA Haydarpasa Hospital, Istanbul, TurkeyDepartment of Medical Oncology, GATA Haydarpasa Hospital, Istanbul, TurkeyDepartment of Medical Oncology, GATA Haydarpasa Hospital, Istanbul, TurkeyDepartment of Medical Oncology, GATA Haydarpasa Hospital, Istanbul, TurkeyDepartment of Medical Oncology, Gazi University Medical Faculty, Ankara, TurkeyThe prognosis of metastatic melanoma is poor. Pre-targeted treatment era, the combination of interferon-α (IF-α) plus chemotherapy had been used and have generally short response duration. Herein, we present a metastatic melanoma case that achieved long-term durable complete response (CR) IF-α plus chemotherapy and IF-α maintenance therapy and had lower Regulatory T (Treg) cells. A fifty-year old woman was admitted to the hospital with metastatic melanoma. Lactate dehydrogenase (LDH) level was 660 U/L. The percentage of CD4+CD25+ Treg cells was 2.4% in CD4+ lymphocytes. The IF-α plus chemotherapy and IF-α maintenance were administered. After six courses of chemotherapy, CR was achieved. Vitiligo and hypothyroidism occurred. The patient has remained in CR for approximately 7 years until second pleural metastases were detected and death. The patient has positive prognostic factors such as induction of autoimmunity, small tumor volume, mild elevated LDH level, and lower Treg cell percentage. She survived long term with CR after IF-α treatment with concurrent chemotherapy and maintenance. IF-α plus chemotherapy may be a treatment option for metastatic melanoma in selected cases who cannot reach new targeted drugs.http://www.sciencedirect.com/science/article/pii/S1110036215000102MelanomaInterferonTreg cellChemotherapy |
| spellingShingle | Bülent Karagöz Oğuz Bilgi Alpaslan Özgün Levent Emirzeoğlu Serkan Çelik Ahmet Özet Long term survival with the combination of interferon and chemotherapy in metastatic melanoma Journal of the Egyptian National Cancer Institute Melanoma Interferon Treg cell Chemotherapy |
| title | Long term survival with the combination of interferon and chemotherapy in metastatic melanoma |
| title_full | Long term survival with the combination of interferon and chemotherapy in metastatic melanoma |
| title_fullStr | Long term survival with the combination of interferon and chemotherapy in metastatic melanoma |
| title_full_unstemmed | Long term survival with the combination of interferon and chemotherapy in metastatic melanoma |
| title_short | Long term survival with the combination of interferon and chemotherapy in metastatic melanoma |
| title_sort | long term survival with the combination of interferon and chemotherapy in metastatic melanoma |
| topic | Melanoma Interferon Treg cell Chemotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S1110036215000102 |
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