Acid Stripping of Surface IgE Antibodies Bound to FcεRI Is Unsuitable for the Functional Assays That Require Long-Term Culture of Basophils and Entire Removal of Surface IgE

Acid Stripping of Surface IgE Antibodies Bound to FcεRI Is Unsuitable for the Functional Assays That Require Long-Term Culture of Basophils and Entire Removal of Surface IgE

Basophils are rare granulocytes and dysregulated functions of these cells are associated with several atopic and non-atopic allergic diseases of skin, respiratory system and gastrointestinal tract. Both cytokines and immunoglobulin E (IgE) are implicated in mediating the basophil activation and path...

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Bibliographic Details
Main Authors: Caroline Galeotti, Anupama Karnam, Mrinmoy Das, Srini V. Kaveri, Jagadeesh Bayry
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
ige
basophil
allergy
atopy
inflammation
human
il-3
activation
lactic acid
acetic acid
stripping
cd123
viability
Online Access:https://www.mdpi.com/1422-0067/21/2/510

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