The mechanism of ions in pulmonary hypertension
Pulmonary hypertension（PH）is a kind of hemodynamic and pathophysiological state, in which the pulmonary artery pressure (PAP) rises above a certain threshold. The main pathological manifestation is pulmonary vasoconstriction and remodelling progressively. More and more studies have found that ions p...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
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| Series: | Pulmonary Circulation |
| Online Access: | https://doi.org/10.1177/2045894020987948 |
| _version_ | 1818113456884154368 |
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| author | Guoyu Liu Daiyan Fu Heshen Tian Aiguo Dai |
| author_facet | Guoyu Liu Daiyan Fu Heshen Tian Aiguo Dai |
| author_sort | Guoyu Liu |
| collection | DOAJ |
| description | Pulmonary hypertension（PH）is a kind of hemodynamic and pathophysiological state, in which the pulmonary artery pressure (PAP) rises above a certain threshold. The main pathological manifestation is pulmonary vasoconstriction and remodelling progressively. More and more studies have found that ions play a major role in the pathogenesis of PH. Many vasoactive substances, inflammatory mediators, transcription-inducing factors, apoptosis mediators, redox substances and translation modifiers can control the concentration of ions inside and outside the cell by regulating the activity of ion channels, which can regulate vascular contraction, cell proliferation, migration, apoptosis, inflammation and other functions. We all know that there are no effective drugs to treat PH. Ions are involved in the occurrence and development of PH, so it is necessary to clarify the mechanism of ions in PH as a therapeutic target for PH. The main ions involved in PH are calcium ion (Ca 2+ ), potassium ion (K + ), sodium ion (Na + ) and chloride ion (Cl – ). Here, we mainly discuss the distribution of these ions and their channels in pulmonary arteries and their role in the pathogenesis of PH. |
| first_indexed | 2024-12-11T03:35:08Z |
| format | Article |
| id | doaj.art-eaf85cbcdafc4ea3bd1ff41780608306 |
| institution | Directory Open Access Journal |
| issn | 2045-8940 |
| language | English |
| last_indexed | 2024-12-11T03:35:08Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Circulation |
| spelling | doaj.art-eaf85cbcdafc4ea3bd1ff417806083062022-12-22T01:22:16ZengWileyPulmonary Circulation2045-89402021-01-011110.1177/2045894020987948The mechanism of ions in pulmonary hypertensionGuoyu LiuDaiyan FuHeshen TianAiguo DaiPulmonary hypertension（PH）is a kind of hemodynamic and pathophysiological state, in which the pulmonary artery pressure (PAP) rises above a certain threshold. The main pathological manifestation is pulmonary vasoconstriction and remodelling progressively. More and more studies have found that ions play a major role in the pathogenesis of PH. Many vasoactive substances, inflammatory mediators, transcription-inducing factors, apoptosis mediators, redox substances and translation modifiers can control the concentration of ions inside and outside the cell by regulating the activity of ion channels, which can regulate vascular contraction, cell proliferation, migration, apoptosis, inflammation and other functions. We all know that there are no effective drugs to treat PH. Ions are involved in the occurrence and development of PH, so it is necessary to clarify the mechanism of ions in PH as a therapeutic target for PH. The main ions involved in PH are calcium ion (Ca 2+ ), potassium ion (K + ), sodium ion (Na + ) and chloride ion (Cl – ). Here, we mainly discuss the distribution of these ions and their channels in pulmonary arteries and their role in the pathogenesis of PH.https://doi.org/10.1177/2045894020987948 |
| spellingShingle | Guoyu Liu Daiyan Fu Heshen Tian Aiguo Dai The mechanism of ions in pulmonary hypertension Pulmonary Circulation |
| title | The mechanism of ions in pulmonary hypertension |
| title_full | The mechanism of ions in pulmonary hypertension |
| title_fullStr | The mechanism of ions in pulmonary hypertension |
| title_full_unstemmed | The mechanism of ions in pulmonary hypertension |
| title_short | The mechanism of ions in pulmonary hypertension |
| title_sort | mechanism of ions in pulmonary hypertension |
| url | https://doi.org/10.1177/2045894020987948 |
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