Multivariate analysis of prognosis of patients with malignant bowel obstruction
Objective To analyze the risk factors for prognosis of patients with malignant bowel obstruction (MBO) using multiple factors, and establish the nomogram model for predicting the survival of patients with MBO. Methods The clinical data of 203 patients with MBO from June 2013 to June 2019 who were fo...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Surgery Concepts & Practice
2022-07-01
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| Series: | Waike lilun yu shijian |
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| Online Access: | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1663654870631-726640704.pdf |
| _version_ | 1797648540461170688 |
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| author | CHENG Wei, HUANG Yuhua, WANG Jian, LI Yousheng |
| author_facet | CHENG Wei, HUANG Yuhua, WANG Jian, LI Yousheng |
| author_sort | CHENG Wei, HUANG Yuhua, WANG Jian, LI Yousheng |
| collection | DOAJ |
| description | Objective To analyze the risk factors for prognosis of patients with malignant bowel obstruction (MBO) using multiple factors, and establish the nomogram model for predicting the survival of patients with MBO. Methods The clinical data of 203 patients with MBO from June 2013 to June 2019 who were followed up in our hospital were analyzed retrospectively. Results A total of 143 (70.4%) patients have been followed up. It was shown with univariate analysis that indexes of gender, age, platelet, C-reactive protein, and total protein levels, comorbidities, the treatment with somatostatin, enteral nutrition, and parenteral nutrition, length of hospital were not related to the survival of patients with MBO. There were some factors including late TNM stage of tumor (P<0.001), tumor metastasis (P<0.001), anemia (P=0.001), lower albumin (P<0.001), higher white blood cell(P=0.023), non-surgical treatment(P=0.013), low quality of life score (P<0.001) and poor liver function [including high alanine aminotransferase (P=0.023), high aspartate aminotransferase (P=0.005)] which related with poorer prognosis in patients with MBO. Multivariate analysis showed that tumor stage (P=0.003) and albumin level(P=0.001) were independent risk factors affecting the prognosis of MBO. Nomogram was constructed using 4 indexes including late TNM stage, tumor metastasis, lower hemoglobin and lower albumin. It was indicated that the results of internal prognosis were better for the prediction of survival of 3 to 12 months of 40 cases. Conclusions The study on poor prognosis of patients with MBO combined with nomogram showed that both late stage of tumor and malnutrition were main factors. |
| first_indexed | 2024-03-11T15:33:35Z |
| format | Article |
| id | doaj.art-eafcc3f41a3f4d89806ae29022cfda93 |
| institution | Directory Open Access Journal |
| issn | 1007-9610 |
| language | zho |
| last_indexed | 2024-03-11T15:33:35Z |
| publishDate | 2022-07-01 |
| publisher | Editorial Office of Journal of Surgery Concepts & Practice |
| record_format | Article |
| series | Waike lilun yu shijian |
| spelling | doaj.art-eafcc3f41a3f4d89806ae29022cfda932023-10-27T02:14:04ZzhoEditorial Office of Journal of Surgery Concepts & PracticeWaike lilun yu shijian1007-96102022-07-01270434034510.16139/j.1007-9610.2022.04.013Multivariate analysis of prognosis of patients with malignant bowel obstructionCHENG Wei, HUANG Yuhua, WANG Jian, LI Yousheng0Department of General Surgery, Shanghai Ninth People′s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, ChinaObjective To analyze the risk factors for prognosis of patients with malignant bowel obstruction (MBO) using multiple factors, and establish the nomogram model for predicting the survival of patients with MBO. Methods The clinical data of 203 patients with MBO from June 2013 to June 2019 who were followed up in our hospital were analyzed retrospectively. Results A total of 143 (70.4%) patients have been followed up. It was shown with univariate analysis that indexes of gender, age, platelet, C-reactive protein, and total protein levels, comorbidities, the treatment with somatostatin, enteral nutrition, and parenteral nutrition, length of hospital were not related to the survival of patients with MBO. There were some factors including late TNM stage of tumor (P<0.001), tumor metastasis (P<0.001), anemia (P=0.001), lower albumin (P<0.001), higher white blood cell(P=0.023), non-surgical treatment(P=0.013), low quality of life score (P<0.001) and poor liver function [including high alanine aminotransferase (P=0.023), high aspartate aminotransferase (P=0.005)] which related with poorer prognosis in patients with MBO. Multivariate analysis showed that tumor stage (P=0.003) and albumin level(P=0.001) were independent risk factors affecting the prognosis of MBO. Nomogram was constructed using 4 indexes including late TNM stage, tumor metastasis, lower hemoglobin and lower albumin. It was indicated that the results of internal prognosis were better for the prediction of survival of 3 to 12 months of 40 cases. Conclusions The study on poor prognosis of patients with MBO combined with nomogram showed that both late stage of tumor and malnutrition were main factors.https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1663654870631-726640704.pdf|malignant bowel obstruction|prognostic factor|surgical treatment|nomogram model |
| spellingShingle | CHENG Wei, HUANG Yuhua, WANG Jian, LI Yousheng Multivariate analysis of prognosis of patients with malignant bowel obstruction Waike lilun yu shijian |malignant bowel obstruction|prognostic factor|surgical treatment|nomogram model |
| title | Multivariate analysis of prognosis of patients with malignant bowel obstruction |
| title_full | Multivariate analysis of prognosis of patients with malignant bowel obstruction |
| title_fullStr | Multivariate analysis of prognosis of patients with malignant bowel obstruction |
| title_full_unstemmed | Multivariate analysis of prognosis of patients with malignant bowel obstruction |
| title_short | Multivariate analysis of prognosis of patients with malignant bowel obstruction |
| title_sort | multivariate analysis of prognosis of patients with malignant bowel obstruction |
| topic | |malignant bowel obstruction|prognostic factor|surgical treatment|nomogram model |
| url | https://www.qk.sjtu.edu.cn/jscp/fileup/1007-9610/PDF/1663654870631-726640704.pdf |
| work_keys_str_mv | AT chengweihuangyuhuawangjianliyousheng multivariateanalysisofprognosisofpatientswithmalignantbowelobstruction |