Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment
Regulatory T cells (Tregs) promote immune suppression in the tumour. Here, the authors show that Tregs suppress cytotoxic T lymphocyte (CTL) activity by impairing Ca2+ signalling and that adoptive transfer of CTLs engineered with an optogenetic control of Ca2+overcome the immune suppression at the t...
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Bibliographic Details
| Main Authors: |
Kyun-Do Kim,
Seyeon Bae,
Tara Capece,
Hristina Nedelkovska,
Rafael G. de Rubio,
Alan V. Smrcka,
Chang-Duk Jun,
Woojin Jung,
Byeonghak Park,
Tae-il Kim,
Minsoo Kim |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2017-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms15365
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