Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment

Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment

Regulatory T cells (Tregs) promote immune suppression in the tumour. Here, the authors show that Tregs suppress cytotoxic T lymphocyte (CTL) activity by impairing Ca2+ signalling and that adoptive transfer of CTLs engineered with an optogenetic control of Ca2+overcome the immune suppression at the t...

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Bibliographic Details
Main Authors: Kyun-Do Kim, Seyeon Bae, Tara Capece, Hristina Nedelkovska, Rafael G. de Rubio, Alan V. Smrcka, Chang-Duk Jun, Woojin Jung, Byeonghak Park, Tae-il Kim, Minsoo Kim
Format: Article
Language:English
Published: Nature Portfolio 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15365

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