CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value
The CKLF-like MARVEL transmembrane domain containing (CMTM) family of genes comprises CKLF and CMTM1–8 (previously called chemokine-like factor superfamily 1–8, CKLFSF1–8). The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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China Anti-Cancer Association
2020-08-01
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| Series: | Cancer Biology & Medicine |
| Subjects: | |
| Online Access: | http://www.cancerbiomed.org/index.php/cocr/article/view/1663 |
| _version_ | 1818350887907622912 |
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| author | Jie Wu Lan Li Siyi Wu Bin Xu |
| author_facet | Jie Wu Lan Li Siyi Wu Bin Xu |
| author_sort | Jie Wu |
| collection | DOAJ |
| description | The CKLF-like MARVEL transmembrane domain containing (CMTM) family of genes comprises CKLF and CMTM1–8 (previously called chemokine-like factor superfamily 1–8, CKLFSF1–8). The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking (MARVEL) domain. Dysregulated expression of multiple CMTM family members is a common feature in many human cancer types. CMTM proteins control critical biological processes in cancer development, including growth factor receptor activation and recycling, cell proliferation, apoptosis, metastasis, and immune evasion. Emerging in vivo and in vitro evidence indicates that the mechanisms of action of most CMTM proteins are complex and multifactorial. This review highlights new findings regarding the roles of CMTM1–8 in cancer, particularly in tumor growth, metastasis, and immune evasion. Additionally, the potential clinical value of CMTMs as novel drug targets or biomarkers is discussed. |
| first_indexed | 2024-12-13T18:28:59Z |
| format | Article |
| id | doaj.art-eaffbe2daf734bfbb271c091a8b1ffdd |
| institution | Directory Open Access Journal |
| issn | 2095-3941 |
| language | English |
| last_indexed | 2024-12-13T18:28:59Z |
| publishDate | 2020-08-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj.art-eaffbe2daf734bfbb271c091a8b1ffdd2022-12-21T23:35:32ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412020-08-0117352854210.20892/j.issn.2095-3941.2020.0032CMTM family proteins 1–8: roles in cancer biological processes and potential clinical valueJie Wu0Lan Li1Siyi Wu2Bin Xu3Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaCancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaCancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaCancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, ChinaThe CKLF-like MARVEL transmembrane domain containing (CMTM) family of genes comprises CKLF and CMTM1–8 (previously called chemokine-like factor superfamily 1–8, CKLFSF1–8). The CMTM family proteins contain a structurally conserved MAL and related proteins for vesicle trafficking and membrane linking (MARVEL) domain. Dysregulated expression of multiple CMTM family members is a common feature in many human cancer types. CMTM proteins control critical biological processes in cancer development, including growth factor receptor activation and recycling, cell proliferation, apoptosis, metastasis, and immune evasion. Emerging in vivo and in vitro evidence indicates that the mechanisms of action of most CMTM proteins are complex and multifactorial. This review highlights new findings regarding the roles of CMTM1–8 in cancer, particularly in tumor growth, metastasis, and immune evasion. Additionally, the potential clinical value of CMTMs as novel drug targets or biomarkers is discussed.http://www.cancerbiomed.org/index.php/cocr/article/view/1663cmtm familycancercell cycleegfremtapoptosistumor immunity |
| spellingShingle | Jie Wu Lan Li Siyi Wu Bin Xu CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value Cancer Biology & Medicine cmtm family cancer cell cycle egfr emt apoptosis tumor immunity |
| title | CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value |
| title_full | CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value |
| title_fullStr | CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value |
| title_full_unstemmed | CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value |
| title_short | CMTM family proteins 1–8: roles in cancer biological processes and potential clinical value |
| title_sort | cmtm family proteins 1 8 roles in cancer biological processes and potential clinical value |
| topic | cmtm family cancer cell cycle egfr emt apoptosis tumor immunity |
| url | http://www.cancerbiomed.org/index.php/cocr/article/view/1663 |
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