A high likelihood of increase in end-stage renal disease among the Japanese HIV-infected population
Abstract Kidneys are affected by human immunodeficiency virus (HIV) infection and its associated therapies. Antiretroviral therapy (ART) has markedly reduced acquired immune deficiency syndrome–related deaths and opportunistic infectious diseases among HIV-infected patients. This contributed to thei...
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| Format: | Article |
| Language: | English |
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BMC
2019-12-01
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| Series: | Renal Replacement Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41100-019-0245-4 |
| _version_ | 1818623534800306176 |
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| author | Minoru Ando Yoko Ando |
| author_facet | Minoru Ando Yoko Ando |
| author_sort | Minoru Ando |
| collection | DOAJ |
| description | Abstract Kidneys are affected by human immunodeficiency virus (HIV) infection and its associated therapies. Antiretroviral therapy (ART) has markedly reduced acquired immune deficiency syndrome–related deaths and opportunistic infectious diseases among HIV-infected patients. This contributed to their prolonged survival; however, the improvement in survival has been accompanied by an increase in the incidence of non-infectious chronic complications, including hypertension, metabolic diseases, and chronic kidney disease (CKD). Recent studies showed that estimated prevalence of any CKD and end-stage renal disease (ESRD) among HIV-infected patients is approximately 20% and 0.5%, respectively, in Japan. Both a rapid decrease in renal function and a high positive rate of albuminuria and proteinuria are clinical characteristics of HIV-infected patients. Moreover, considering higher complication rates of hypertension and diabetes compared with non-HIV-infected individuals of the similar aging, HIV-infected patients who develop CKD and ESRD are very likely to increase. Furthermore, as the survival rate is favorable after the initiation of dialysis, the cumulative number of ESRD patients is supposed to increase. The corporation for treatment of HIV-positive hemodialysis patients by general dialysis clinics will be urgently required; however, there still remain some preoccupations and prejudices about HIV per se in Japan, which may provoke hesitation from accepting those patients. |
| first_indexed | 2024-12-16T18:42:36Z |
| format | Article |
| id | doaj.art-eb011fa1ab0a41d28ab360fdd6cbf4df |
| institution | Directory Open Access Journal |
| issn | 2059-1381 |
| language | English |
| last_indexed | 2024-12-16T18:42:36Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Renal Replacement Therapy |
| spelling | doaj.art-eb011fa1ab0a41d28ab360fdd6cbf4df2022-12-21T22:20:58ZengBMCRenal Replacement Therapy2059-13812019-12-01511910.1186/s41100-019-0245-4A high likelihood of increase in end-stage renal disease among the Japanese HIV-infected populationMinoru Ando0Yoko Ando1Department of Medicine, Jiseikai Memorial HospitalDivision of Health Care, Kanto-Shinetsu Regional Taxation BureauAbstract Kidneys are affected by human immunodeficiency virus (HIV) infection and its associated therapies. Antiretroviral therapy (ART) has markedly reduced acquired immune deficiency syndrome–related deaths and opportunistic infectious diseases among HIV-infected patients. This contributed to their prolonged survival; however, the improvement in survival has been accompanied by an increase in the incidence of non-infectious chronic complications, including hypertension, metabolic diseases, and chronic kidney disease (CKD). Recent studies showed that estimated prevalence of any CKD and end-stage renal disease (ESRD) among HIV-infected patients is approximately 20% and 0.5%, respectively, in Japan. Both a rapid decrease in renal function and a high positive rate of albuminuria and proteinuria are clinical characteristics of HIV-infected patients. Moreover, considering higher complication rates of hypertension and diabetes compared with non-HIV-infected individuals of the similar aging, HIV-infected patients who develop CKD and ESRD are very likely to increase. Furthermore, as the survival rate is favorable after the initiation of dialysis, the cumulative number of ESRD patients is supposed to increase. The corporation for treatment of HIV-positive hemodialysis patients by general dialysis clinics will be urgently required; however, there still remain some preoccupations and prejudices about HIV per se in Japan, which may provoke hesitation from accepting those patients.https://doi.org/10.1186/s41100-019-0245-4AlbuminuriaCystatin CEstimated glomerular filtration rateProteinuriaUrinary biomarker |
| spellingShingle | Minoru Ando Yoko Ando A high likelihood of increase in end-stage renal disease among the Japanese HIV-infected population Renal Replacement Therapy Albuminuria Cystatin C Estimated glomerular filtration rate Proteinuria Urinary biomarker |
| title | A high likelihood of increase in end-stage renal disease among the Japanese HIV-infected population |
| title_full | A high likelihood of increase in end-stage renal disease among the Japanese HIV-infected population |
| title_fullStr | A high likelihood of increase in end-stage renal disease among the Japanese HIV-infected population |
| title_full_unstemmed | A high likelihood of increase in end-stage renal disease among the Japanese HIV-infected population |
| title_short | A high likelihood of increase in end-stage renal disease among the Japanese HIV-infected population |
| title_sort | high likelihood of increase in end stage renal disease among the japanese hiv infected population |
| topic | Albuminuria Cystatin C Estimated glomerular filtration rate Proteinuria Urinary biomarker |
| url | https://doi.org/10.1186/s41100-019-0245-4 |
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