GERM CELL TUMOURS OF THE OVARY IN CHILDREN AND ADOLESCENTS: A CLINICAL STUDY OF 109 PATIENTS IN A SPECIALIZED CANCER CENTRE
Objective: Paediatric ovarian germ cell tumours (GCTs) are rare tumours with malignant tumours extremely rare. Methods: All the paediatric patients who received treatment for histology proven ovarian GCT at Shaukat Khanum Memorial Cancer Hospital from January 2006 to December 2014 were retrospecti...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Shaukat Khanum Memorial Trust
2018-07-01
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| Series: | Journal of Cancer and Allied Specialties |
| Online Access: | http://journals.sfu.ca/jcas/index.php/jcas/article/view/99 |
| _version_ | 1828953034063872000 |
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| author | Irfan Ul Islam Nasir Muhammad Fahd Shah Awais Amjad Malik Abdul Wahid Anwer Amir Ali Syed Abid Quddus Qazi |
| author_facet | Irfan Ul Islam Nasir Muhammad Fahd Shah Awais Amjad Malik Abdul Wahid Anwer Amir Ali Syed Abid Quddus Qazi |
| author_sort | Irfan Ul Islam Nasir |
| collection | DOAJ |
| description | Objective: Paediatric ovarian germ cell tumours (GCTs) are rare tumours with
malignant tumours extremely rare.
Methods: All the paediatric patients who received treatment for histology proven ovarian GCT at Shaukat Khanum Memorial Cancer Hospital from January 2006 to December 2014 were retrospectively reviewed. Patients over the age of 18 years were excluded from the study. A total of 109 patients were included in the study. A set of parameters were identified to record initial clinical presentation and examination, imaging and laboratory investigations including tumour marker levels. Decisions of multidisciplinary team meetings, surgical treatment, neo adjuvant, adjuvant chemotherapy and radiation data retrieved. Data analysiscarried out using SPSS 20.
Results: In total 109 girls presented to our hospital during the study period, most of them above the age of 5 years, with dysgerminoma being the most common followed by yolk sac tumour. Most of the patients received treatment outside our hospital and were referred here for chemoradiotherapy. Fertility preserving surgery was the most commonly performed surgical procedure with a mean follow-up of 50.4 months and >75% overall 5-year survival.
Conclusion: Regardless of histologic types, the outcomes of GCT can be improved with a multidisciplinary approach.
Key words: Dysgerminomas, germ cell tumours, ovarian tumours |
| first_indexed | 2024-12-14T07:03:05Z |
| format | Article |
| id | doaj.art-eb02c8b3ebfe464482fef8efb52bbd06 |
| institution | Directory Open Access Journal |
| issn | 2411-989X |
| language | English |
| last_indexed | 2024-12-14T07:03:05Z |
| publishDate | 2018-07-01 |
| publisher | Shaukat Khanum Memorial Trust |
| record_format | Article |
| series | Journal of Cancer and Allied Specialties |
| spelling | doaj.art-eb02c8b3ebfe464482fef8efb52bbd062022-12-21T23:12:21ZengShaukat Khanum Memorial TrustJournal of Cancer and Allied Specialties2411-989X2018-07-014210.37029/jcas.v4i2.99GERM CELL TUMOURS OF THE OVARY IN CHILDREN AND ADOLESCENTS: A CLINICAL STUDY OF 109 PATIENTS IN A SPECIALIZED CANCER CENTREIrfan Ul Islam Nasir0Muhammad Fahd Shah1Awais Amjad Malik2Abdul Wahid Anwer3Amir Ali SyedAbid Quddus QaziFellow Surgical Oncology Shaukat Khanum Memorial Cancer Hospital and Research CenterFellow Surgical Oncology Shaukat Khanum Memorial Cancer Hospital and Research CenterFellow Surgical Oncology Shaukat Khanum Memorial Cancer Hospital and Research CenterFellow Surgical Oncology Shaukat Khanum Memorial Cancer Hospital and Research CenterObjective: Paediatric ovarian germ cell tumours (GCTs) are rare tumours with malignant tumours extremely rare. Methods: All the paediatric patients who received treatment for histology proven ovarian GCT at Shaukat Khanum Memorial Cancer Hospital from January 2006 to December 2014 were retrospectively reviewed. Patients over the age of 18 years were excluded from the study. A total of 109 patients were included in the study. A set of parameters were identified to record initial clinical presentation and examination, imaging and laboratory investigations including tumour marker levels. Decisions of multidisciplinary team meetings, surgical treatment, neo adjuvant, adjuvant chemotherapy and radiation data retrieved. Data analysiscarried out using SPSS 20. Results: In total 109 girls presented to our hospital during the study period, most of them above the age of 5 years, with dysgerminoma being the most common followed by yolk sac tumour. Most of the patients received treatment outside our hospital and were referred here for chemoradiotherapy. Fertility preserving surgery was the most commonly performed surgical procedure with a mean follow-up of 50.4 months and >75% overall 5-year survival. Conclusion: Regardless of histologic types, the outcomes of GCT can be improved with a multidisciplinary approach. Key words: Dysgerminomas, germ cell tumours, ovarian tumourshttp://journals.sfu.ca/jcas/index.php/jcas/article/view/99 |
| spellingShingle | Irfan Ul Islam Nasir Muhammad Fahd Shah Awais Amjad Malik Abdul Wahid Anwer Amir Ali Syed Abid Quddus Qazi GERM CELL TUMOURS OF THE OVARY IN CHILDREN AND ADOLESCENTS: A CLINICAL STUDY OF 109 PATIENTS IN A SPECIALIZED CANCER CENTRE Journal of Cancer and Allied Specialties |
| title | GERM CELL TUMOURS OF THE OVARY IN CHILDREN AND ADOLESCENTS: A CLINICAL STUDY OF 109 PATIENTS IN A SPECIALIZED CANCER CENTRE |
| title_full | GERM CELL TUMOURS OF THE OVARY IN CHILDREN AND ADOLESCENTS: A CLINICAL STUDY OF 109 PATIENTS IN A SPECIALIZED CANCER CENTRE |
| title_fullStr | GERM CELL TUMOURS OF THE OVARY IN CHILDREN AND ADOLESCENTS: A CLINICAL STUDY OF 109 PATIENTS IN A SPECIALIZED CANCER CENTRE |
| title_full_unstemmed | GERM CELL TUMOURS OF THE OVARY IN CHILDREN AND ADOLESCENTS: A CLINICAL STUDY OF 109 PATIENTS IN A SPECIALIZED CANCER CENTRE |
| title_short | GERM CELL TUMOURS OF THE OVARY IN CHILDREN AND ADOLESCENTS: A CLINICAL STUDY OF 109 PATIENTS IN A SPECIALIZED CANCER CENTRE |
| title_sort | germ cell tumours of the ovary in children and adolescents a clinical study of 109 patients in a specialized cancer centre |
| url | http://journals.sfu.ca/jcas/index.php/jcas/article/view/99 |
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